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| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | Fine needle as piration cytology and immunoeytochemistry in the diagnosis of 24 gastrointes- tinal stromal tumors 显示文摘 | Lozano MD Rodriguez J Algarra SM | 2003 | Diagn Cytopathol2003，28，3： | 1 |
| 3 | Highly Selective Determination of Dopamine in the Presence of Ascorbic Arid and Serotonin at Glassy Carbon Electrodes Modified with Carbon Nanotubes Dispersed in Polyethylenimine显示文摘 | Rodriguez MC Rubianes MD Rivas GA | 2008 | J Nancaci Nanotechnol2008，8，11： | 1 |
| 4 | Once daily sublingual immunotherapy without updosing--a new treatment schedule 显示文摘 | Rodriguez F Boquete M Ibanez MD | 2006 | Int Arch Allergy Immunol2006，140，4： | 1 |
| 5 | A network approach to assessing cognition in disorders of consciousness显示文摘 | Rodriguez MD Schiff ND Giacino J | 2010 | Neurology2010，75，： | 1 |
| 6 | High - dose chemotherapy and autologous stem cell transplantation in peripheral T- cell lymphoma: the GEL -TAMO experience 显示文摘 | Rodriguez J Caballero MD Gutierrez A | 2003 | Ann Oncol2003，14，： | 1 |
| 7 | Abdominal pelvic actinomycosis with urinary tract involvenment,secondary to gynecologic infection caused by intrauterine divices显示文摘 | Perez Garcia MD Rodriguez Alonso A Nunez Lopez A | 2000 | Acfas Urol Esp2000，24，2： | 1 |
| 8 | Central serous chori- oretinopathy of unusual etiology:a report of 2 cases 显示文摘 | Palacios AI Rodriguez M Martin MD | 2014 | Arch Soc Esp Oftalmol2014，89，7： | 1 |
| 9 | High-dose chemotherapy and autologous stem cell transplantation in peripheral T-cell lymphoma:The GEL-TAMO experience 显示文摘 | Rodriguez J Caballero MD Gutierrez A | 2003 | Ann Oncol2003，14，： | 1 |
| 10 | 当前吸烟增加高血压发病风险:西班牙裔社区健康研究-拉美裔研究显示文摘高血压是与吸烟相关的心血管病危险因素,但高血压和吸烟的剂量效应关系尚不清楚。本研究针对西班牙裔人群,他们吸烟暴露通常相对较低。方法:研究采用美国西班牙裔18~76岁成年人6年随访研究的数据,明确吸烟与高血压的剂量效应。高血压定义为血压≥140/90mm Hg(1 mm Hg=0.133kPa)或服用降压药。校正潜在的混杂因素及中介因素,包括尿白蛋白与肌酐比值(在吸烟者中随时间推移而恶化)。 | Kaplan RC Baldoni PL Strizich GM Perez-Stable EJ Sacco-ne NL Peralta CA Perreira KM Gellman MD Williams-Nguyen JS Rodriguez CJ Lee DJ Daviglus M Talavera GA Lash JP Cai J Franceschini N 袁源(翻译) 郑武洪(审校) | 2021 | 中华高血压杂志2021，29，12： | 1 |
| 11 | Creatine kinase BB and neuron-specific enolase in cerebrospinal fluid in the diagnosis of brain insult 显示文摘 | Sanchez Rodriguez F Osuna E | 1995 | Am J Forensic Med Pathol1995，16，3： | 1 |
| 12 | Potential vasorelaxant effects of oleanolic acid and erythro -diol, two triterpenoids contained in ‘orujo' olive oil, on rat aorta显示文摘 | Rodriguez - Rodriguez R Herrera MD Perona JS | 2004 | Br J Nutr2004，92，4： | 1 |
| 13 | Fine-needle aspiration cytology and immunocytochemistry in the diagnosis of 24 gastrointestinal stromal tumors:a quick,reliable diagnostic method显示文摘 | Lozano MD Rodriguez J Algarra SM | 2003 | Diagn Cytopathol2003，28，3： | 1 |
| 14 | Clinical epidemiology of Stenotrophomonas maltophilia colonization and infection: a multicenter study显示文摘 | Toro MD Rodriguez BJ Herrero MR | 2002 | Medicine(Baltimore)2002，81，： | 1 |
| 15 | Antioxidant intervention attenuates myocardial neovascularization in hypercholesterolemia 显示文摘 | Zhu XY Rodriguez - Porcel M Bentley MD | 2004 | Circulation2004，109，17： | 1 |
| 16 | Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vlvo ac- tivity in rat behavioral models of anxiolytic and antipsychotic ac- tivity显示文摘 | RODRIGUEZ AL GRIER MD JONES CK | 2010 | Mol Pharmacol2010，78，6： | 1 |
| 17 | Abdominal wallhernias after open abdominal aortic aneurysm repair: prospectiveradiographic detection and clinical implications 显示文摘 | Rodriguez HE Matsumura JS Morasch MD | 2004 | VaseEndovascular Surg2004，38，3： | 1 |
| 18 | Clinical significance of cathepsin D concentration in tumor cytosol of primary breast cancer显示文摘 | Rodriguez J Vazquez J Corte MD | 2005 | Int J Biol Markers2005，20，2： | 1 |
| 19 | Labat法坐骨神经阻滞下局部麻醉药低容量高浓度较高容量低浓度更有效:一项前瞻性随机对照研究显示文摘背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率,本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时,单剂量的甲哌卡因300mg分别稀释至20和30ml注射后的阻滞效果差异。方法90例行足部手术的患者,随机分为2组接受坐骨神经阻滞,一组给予1.5%甲哌卡因20m1(45例),另一组给予1%甲哌卡因30m1(45例),所有阻滞均在神经刺激仪定位下进行(参数为刺激频率2Hz;刺激电流为1.5~0.5mA)。两组中,神经刺激反应在〈0.5mA时引出,亦可以定向诱发足部肌肉向跖侧屈曲,分别记录胫神经和腓总神经的运动感觉功能被阻滞的起效时间。而坐骨神经支配区域的针刺感觉消失,同时足部跖曲及背曲运动消失为阻滞成功的标准。结果用20ml的1.5%甲哌卡因组阻滞成功率(96.6%)显著高于30ml的1%甲哌卡因组(68.9%,P〈0.05)。而前者达到感觉与运动完全阻滞所需要的时间(11±6分钟,13±7分钟)也短于后者(17±8分钟,19±8分钟,P〈0.05)。结论Labat法行坐骨神经阻滞时,与高容量低浓度的局部麻醉药(1%甲哌卡因)比较,使用低容量高浓度的局部麻醉药(1.5%甲哌卡因)能够获得更高的阻滞成功率及更短的起效时间。 | Manuel Taboada Muniz, MD, PhD Jaime Rodriguez, MD, PhD Maria Bermudez, MD Cristina Valino, MD Noemi Blanco, MD Marcos Amor, MD Pilar, Aguirre, MD Ana Masid, MD Joaquin Cortes, MD, Ph Julian Alvarez, MD, PhD Peter G. Atanassoff, MD 杨光(译) 崔苏扬(校) | 2010 | 麻醉与镇痛2010，，2： | 1 |
| 20 | High dose chemotherapy and autologous stem cell transplantation in patients with peripheral T-cell lymphoma not achieving complete response after induction chemotherapy 显示文摘 | Rodriguez J Caballero MD Gutierrez A | 2003 | Hematology2003，88，： | 1 |
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