|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma显示文摘AIM: To evaluate the tissular expression of Androgen (A), Estrogen (E) and Progesterone (Pg) receptors, and Apolipoprotein D (ApoD), in liver tumors from resected hepatocellular carcinoma (HCC) cases in order to assess their possible relationship to prognosis. METHODS: We performed an immunohistochemical study using tissue microarrays (containing more than 260 cancer specimens, from 31 HCC patients and controls) to determine the presence of specif ic antibodies against AR, ER, PgR and ApoD, correlating their findings with several clinico-pathological and biological variables. The staining results were categorized using a semi-quantitive score based on their intensity, and the percentage of immunostained cells was measured. RESULTS: A total of 21 liver tumors (67.7%) were positive for AR; 16 (51.6%) for ER; 26 (83.9%) for PgR and 12 (38.7%) stained for ApoD. We have found a wide variability in the immunostaining score values for each protein, with a median (range) of 11.5 (11.5-229.5) for AR; 11.1 (8.5-65) for ER; 14.2 (4-61) for PgR; and 37.7 (13.8-81.1) for ApoD. A history of heavy ethanol consumption, correlated positively with AR and PgR and negatively with ER status. HCV chronic infection also correlated positively with AR and PgR status. However, the presence of ApoD immunostaining did not correlate with any of these variables. Tumors with a positive immuno-staining for PgR showed a better prognosis. CONCLUSION: Our results indicate a moderate clinical value of the steroid receptor status in HCC, emphasizing the need to perform further studies in order to evaluate the possible role of new hormonal-based therapies. | FJ Vizoso M Rodriguez A Altadill ML González-Diéguez A Linares LO González S Junquera F Fresno-Forcelledo MD Corte L Rodrigo | 2007 | World Journal of Gastroenterology2007，13，23： | 11 |
| 2 | 多形性黄色瘤型星形细胞瘤:自然病史和长期随访显示文摘作者回顾性研究74例多形性黄色瘤型星形细胞瘤(PXA)组织学问变特征和BRAFV600E突变的预后意义。患者平均诊断年龄21.5岁,包括31例儿童和43例成人,随访中位时间为7.6年。间变特征(PXA—AF)定义为核分裂指数≥5个/10HPF和(或)伴有坏死,共有33例。作者将其中60例进行免疫组化和(或)分子分析,发现其中39例BRAFV600E突变,且这39例IDH1(R132H)均为阴性。 | Ida C M Rodriguez F J Burger P C 李晓玲 王行富 | 2015 | 临床与实验病理学杂志2015，31，11： | 9 |
| 3 | ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy显示文摘响应滋养的应力,房间开始能导致改编或死亡的一个 autophagy 节目。位于从饥饿发信号到 autophagy 的开始下面的机制充分没被理解。在当前的学习,我们证明 PARP-1 的缺席或 inactivation 强烈推迟导致饥饿的 autophagy。我们发现了那 DNA 损坏是由 γ 测量了的导致饥饿的 autophagy 的一个早事件; -H2AX 累积和彗星试金,与在两个参数显示减小的 PARP-1 猛烈房间。在饥饿期间,导致 ROS 的 DNA 损坏激活 PARP-1,导致 ATP 弄空(在滋养的剥夺以后的一个早事件) 。PARP-1 的缺席弄钝 AMPK 激活并且阻止了 mTOR 活动的完全的损失,导致在 autophagy 的延期。PARP-1 弄空在饥饿的房间赞成 apoptosis,建议在滋养的剥夺以后的 autophagy 和 PARP-1 激活的一个支持幸存的角色。在 PARP-1 变异的老鼠的出生不满一月的婴儿使遭到了到尖锐饥饿的 vivo 结果表演,也显示缺乏的肝 autophagy,暗示为在导致饥饿的 autophagy 的 PARP-1 的一个生理的角色。因此,表明小径的 PARP 是 autophagy 承诺追随者饥饿的起始的步骤的一个关键管理者。 | Jose Manuel Rodriguez-Vargas Maria Jose Ruiz-Magana Carmen Ruiz-Ruiz Jara Majuelos-Melguizo Andreina Peralta-Lea Maria Isabel Rodriguez Jose Antonio Munoz-Gaimez Mariano Ruiz de Almodovar Eva Siles Abelardo Lopez Rivas Marja Jaattela F Javier Oliver | 2012 | Cell Research2012，22，7： | 8 |
| 4 | DNA immunization:ubiquitination of a viral protein enhances cytotoxic T-lymphocyte induction and antiviral protection but abrogates antibody induction显示文摘 | Rodriguez F Zhang J Whitton J L | 1997 | J Virol1997，71，： | 2 |
| 5 | Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry 显示文摘 | Giuffrida A Rodriguez de Fonseca F Piomelli D | 2000 | Anal Biochem2000，280，1： | 1 |
| 6 | Building geometric fealure based maps for indoor service robots 显示文摘 | RODRIGUEZ L D MATIA F GALAN R | 2006 | Robotics and Autonomous Systems2006，54，7： | 1 |
| 7 | Adipocyte differentiation of multipotent cells established from human adipose tissue显示文摘 | Elabd C Delteil F | 2004 | Biochem Biophys Res Commun2004，315，2： | 1 |
| 8 | Lysyl oxidase (LOX) down--regulation by TNFa: a new mechanism underlying TNFa--indueed endothelial dysfunction显示文摘 | Rodriguez C Alcudia J F Martinez--Gonzalez J | 2008 | Atherosclerosis2008，196，： | 1 |
| 9 | Gains from corporate headquarters relocations: evidence from the stock market 显示文摘 | Ghosh C Rodriguez M Sirmans C F | 1995 | Journal of Urban Economics1995，38，： | 1 |
| 10 | Structural integrity of hot strip mill rolling rolls显示文摘 | Belzunce F J Ziadi A Rodriguez C | 2004 | Engineering Failure Analysis2004，11，78： | 1 |
| 11 | Characteristics of the heterotrophic population in hypersaline environments of different salt concentration显示文摘 | RODRIGUEZ V F RUIZ B F RAMOS C A | 1981 | Microbiol Ecol1981，7，： | 1 |
| 12 | Quantitative and qualitative analyses of the immune responses induced by a multivalent minigene DNA vaccine显示文摘 | An LL Rodriguez F Harkins S | 2000 | Vaccine2000，18，20： | 1 |
| 13 | Inducible nuclear expression of newly synthesized IкBα negatively regu-Isles DNA-binding and transcriptional activities of NF-кB 显示文摘 | Arenzana-Seisdedos F Thompson J Rodriguez MS | 1995 | Mol Cell Biol1995，15，8： | 1 |
| 14 | c-myc,c-erb-B2,nm23 and p53 expression in human endometriosis显示文摘 | Schneider J Jimenez E Rodriguez F | 1998 | Oncol Rep1998，5，1： | 1 |
| 15 | Mice cloned from embryonic stem cell显示文摘 | Wakayama T Rodriguez I Perry A C F | 1999 | Proc Natl Acad Sci USA1999，，14： | 1 |
| 16 | Influence of testing methodology on the tigecycline activity profile against presumably tigecycline-non-susceptible Acinetobacter spp显示文摘 | Casal M Rodriguez F Johnson B | 2009 | JAntimicrob Chemother2009，64，1： | 1 |
| 17 | Implants for orthodontic anchorage:success rates and reasons of failures 显示文摘 | Rodriguez JC Suarez F Chan HL | 2014 | Implant Dent2014，23，2： | 1 |
| 18 | Value of accessibility to Bogata's bus rapid transit system显示文摘 | Rodriguez D Targa F | | 0，，05： | 1 |
| 19 | Infectious bursal dis- ease virus capsid assembly and maturation by structural rear- rangements of a transient molecular switch 显示文摘 | Luque D Saugar I Rodriguez J F | 2007 | J Virol2007，81，13： | 1 |
| 20 | The epidemi- ology of sepsis in Colombia: a prospective muhicenter co- hort study in ten university hospitals显示文摘 | Rodriguez F Barrera L De La Rosa G | 2011 | Crit Care Med2011，39，7： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员