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| 1 | A single administration of fish oil inhibits the acute inflammatory response in rats显示文摘Objective: To investigate the antiinflammatory effects of a single administration of fish oil(FO) on the acute inflammatory response. Methods: The paw edema and pleurisy models were used to evaluate the effects of FO dissolved in olive oil(FOP) orally administered in a single dose in rats. Nitric oxide(NO) concentrations in the pleural exudate were performed according to the Griess method and the cytokine concentrations were determined by Luminex bead-based multiplex assay. Results: FOP treatment(30 and 300 mg/kg) significantly reduced paw edema. FOP treatment at 18.75, 37.5, 75.0, 150.0, and 300 mg/kg decreased both the volume of pleural exudate and cellular migration into the pleural cavity and each of these doses presented the same effectiveness. Treatment with FOP(300 mg/kg) reduced NO, TNF-α, IL-1β, and IL-6 concentrations in the pleural exudate. Conclusions: The present data provide evidence that FO has inhibitory effects on the acute inflammatory response when administered in a single dose in rats. This effect might be attributable to a direct inhibitory effect of FO on the production or release of inflammatory mediators that are involved in the pathological processes evaluated herein. | Laura Licia Milani de Arruda Franciele Queiroz Ames Damila Rodrigues de Morais Renata Grespan Ana Paula Maziero Gil Maria Angelica Raffaini Covas Pereira Silva Jesui Vergilio Visentainer Roberto Kenji Nakamura Cuman Ciomar Aparecida Bersani-Amado | 2017 | Asian Pacific Journal of Tropical Medicine2017，10，8： | 2 |
| 2 | Liquid chromatographic methods for determination of the new antiepileptic drugs stiripentol, retigabine, rufinamide and perampanel: A comprehensive and critical review显示文摘The new antiepileptic drugs perampanel,retigabine,rufinamide and stiripentol have been recently approved for different epilepsy types.Being them an innovation in the antiepileptics armamentarium,a lot of investigations regarding their pharmacological properties are yet to be performed.Besides,considering their broad anticonvulsant activities,an extension of their therapeutic indications may be worthy of investigation,especially regarding other seizure types as well as other central nervous system disorders.Although different liquid chromatographic(LC)methods coupled with ultraviolet,fluorescence,mass or tandem-mass spectrometry detection have already been developed for the determination of perampanel,retigabine,rufinamide and stiripentol,new and more cost-effective methods are yet required.Therefore,this review summarizes the main analytical aspects regarding the liquid chromatographic methods developed for the analysis of perampanel,retigabine(and its main active metabolite),rufinamide and stiripentol in biological samples and pharmaceutical dosage forms.Furthermore,the physicochemical and stability properties of the target compounds will also be addressed.Thus,this review gathers,for the first time,important background information on LC methods that have been developed and applied for the determination of perampanel,retigabine,rufinamide and stiripentol,which should be considered as a starting point if new(bio)analytical techniques are aimed to be implemented for these drugs. | Sara Meirinho Marcio Rodrigues Ana Fortuna Amílcar Falcao Gilberto Alves | 2021 | Journal of Pharmaceutical Analysis2021，11，4： | 2 |
| 3 | Physicochemical and harvest time akerations in pineapple fruits 'Smooth Cayenne' caused by paclobutrazol 显示文摘 | Antunes AM Ono EO Sampaio AC Rodrigues JD | 2008 | Brazilian Archives of Biology and Technology2008，51，1： | 1 |
| 4 | Urodynamie pressure flow studies can predict the clinical outcome after transurethal prostatic section显示文摘 | Rodrigues P Lucon AM Freire GC | 2001 | J Urol2001，165，2： | 1 |
| 5 | Autoantibody production in chronic idiopathic urticaria is not associated with Helicobacter pylori infection显示文摘 | Rodrigues MZ Sousa CP | 2004 | Braz J Med Biol Res2004，37，1： | 1 |
| 6 | Thera- peutic potential of treatment with the flavonoid turin atter cortical fo- cal ischemia in rats显示文摘 | Rodrigues AM Marcilio Fdos S Fraz~o Muzitano M | 2013 | Brain Res2013，1503，： | 1 |
| 7 | Being an Informal Care- giver of a Person with a Pressure Ulcer in the Azores Islands 显示文摘 | Rodrigues AM Ferr6-Grau C Ferreira PL | 2015 | Adv Skin Wound Care2015，28，10： | 1 |
| 8 | MLPA as ascreening method of aneuploidy and unbalanced chromosomalrearrangements in spontaneous miscarriages显示文摘 | Diego AD Rodrigued de AM Cardero MR | | 0，，8： | 1 |
| 9 | Comparative effectiveness and predictors of response to tumor necrosis factor inhibitor therapies in rheumatoid arthritis显示文摘 | Canh(a)o h Rodrigues AM Mour(a)o AF | 2012 | Rheumatology2012，51，11： | 1 |
| 10 | Urodynam icpressure flow studies can predict the clinical outcome after transurethral prostatic resection resetiom显示文摘 | Rodrigues P Lucon AM Fieire G C | 2001 | Urol2001，165，： | 1 |
| 11 | Random izad study of bipolar vessel sealing system versysconventional suture ligature for vaginal hysterectomy显示文摘 | Silva-Filho AL Rodrigues AM Vale de Castro M on teino M | 2009 | Eur JObstet Gynecol Reprod Biol2009，146，2： | 1 |
| 12 | A rare cause of neural foraminal widening显示文摘 | Rodrigues JC Mortimer AM Love S | 2012 | J Radiol Case Rep2012，6，12： | 1 |
| 13 | Dynamic contrast- enhanced 3 -T magnetic resonance imaging: a method for quantifying disease activity in early polyarthritis 显示文摘 | Navalho M Resende C Rodrigues AM | 2012 | Skeletal Radiol2012，41，1： | 1 |
| 14 | Urodynamic pressure flow studies can predict the clinical outcome after transurethral prostatic resection 显示文摘 | RODRIGUES P LUCON AM FREIRE GC | 2001 | J Urol2001，165，： | 1 |
| 15 | Bilateral evaluation of the hand and wrist in untreated early inflammatory arthritis:a comparative study of ultrasonography and magnetic resonance imaging显示文摘 | Navalho M Resende C Rodrigues AM | 2013 | Rheumatology2013，40，8： | 1 |
| 16 | Susceptibility of Sporothrix brasiliensis isolates to amphotericin B,azoles,and terbinafine显示文摘 | Borba-Santos LP Rodrigues AM Gagini TB | 2015 | Med Mycol2015，53，2： | 1 |
| 17 | Transmitted Drug Resis-tance among People Living with HIV/AIDS at Major Cities of SaoPaulo State, Brazil 显示文摘 | Ferreira JL Rodrigues R Lanca AM | 2013 | Adv Virol2013，2013，87： | 1 |
| 18 | Primary biliary cirrhosis in a rheumatoid arthritis patient treated with rituximab,a case-based review显示文摘 | Polido-Pereira J Rodrigues AM Canhao H | 2012 | Clin Rheumatol2012，31，2： | 1 |
| 19 | Comparison between results of trabeculectomy in primary congenital glaucoma with and without the use of mitomycin C显示文摘 | Rodrigues AM Junior AP Montezano FT | 2004 | J Glaucoma2004，13，3： | 1 |
| 20 | Rituximab use in pediatric autoimmune diseases:four case reports 显示文摘 | Polido-Pereira J Ferreira D Rodrigues AM | 2009 | Ann NY Acad Sci2009，1173，： | 1 |
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