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| 1 | Role of quorum sensing in bacterial infections显示文摘Quorum sensing(QS) is cell communication that is widely used by bacterial pathogens to coordinate the expression of several collective traits, including the production of multiple virulence factors, biofilm formation, and swarming motility once a population threshold is reached. Several lines of evidence indicate that QS enhances virulence of bacterial pathogens in animal models as well as in human infections; however, its relative importance for bacterial pathogenesis is still incomplete. In this review, we discuss the present evidence from in vitro and in vivo experiments in animal models, as well as from clinical studies, that link QS systems with human infections. We focus on two major QS bacterial models, the opportunistic Gram negative bacteria Pseudomonas aeruginosa and the Gram positive Staphylococcus aureus, which are also two of the main agents responsible of nosocomial and wound infections. In addition, QS communication systems in other bacterial, eukaryotic pathogens, and even immune and cancer cells are also reviewed, and finally, the new approaches proposed to combat bacterial infections by the attenuation of their QS communication systems and virulence are also discussed. | Israel Castillo-Juárez Toshinari Maeda Edna Ayerim Mandujano-Tinoco María Tomás Berenice Pérez-Eretza Silvia Julieta García-Contreras Thomas K Wood Rodolfo García-Contreras | 2015 | World Journal of Clinical Cases2015，3，7： | 15 |
| 2 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet2014，，9911： | 3 |
| 3 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | 2014 (9911)2014，，9911： | 2 |
| 4 | Morphology and sedimentology of two contemporary fan deltas on the southeastern Baja California Peninsula, Mexico显示文摘 | Enrique N S Rodolfo C O Donn S G | 1995 | Sedimentary Geology1995，98，： | 1 |
| 5 | LUISI A Market Orientation,Innovation and Competitive Strategies in Industrial Firms显示文摘 | RODOLFO V MARIA L S | 2001 | Journal of Strategic Marketing2001，，9： | 1 |
| 6 | Decennial follow - up in patients with recurrent tachycardia originating from the right ventricular outflow tract: electrophysiologic characteristics and response to treatment 显示文摘 | Rodolfo V Daniel S Hanno UK | 2007 | European Heart Journal2007，28，19： | 1 |
| 7 | Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome显示文摘 | Carlos Zamarrón Luis Valdés Cuadrado Rodolfo álvarez-Sala Francisco García Río | 2013 | <journal-title>Pulmonary Medicine2013，，： | 1 |
| 8 | Catheter ablation of stable ventricular tachycardia before defibrillator implantation in patients with coronary heart disease (VTACH): a multicentre randomised controlled trial显示文摘 | Karl-Heinz Kuck Anselm Schaumann Lars Eckardt Stephan Willems Rodolfo Ventura Etienne Delacrétaz Heinz-Friedrich Pitschner Josef Kautzner Burghard Schumacher Peter S Hansen | 2010 | The Lancet2010，，9708： | 1 |
| 9 | Hormonal regulation of dormancy in developing sorghum seeds 显示文摘 | Haydee S S Oberto L Benech- Arnold Rodolfo A SOnchez | 1997 | Plant Physiology1997，113，2： | 1 |
| 10 | 2004 WHO classification of the renal tumors of the adults显示文摘 | ANTONIO L A MARINA S I RODOLFO M | 2006 | European Urology2006，49，5： | 1 |
| 11 | Subthreshold membrane potential oscillations in inferior olive neurons are dynamically regulated by P/Q‐ and T‐type calcium channels: a study in mutant mice显示文摘 | SoonwookChoi EunahYu DaesooKim Francisco J.Urbano VladimirMakarenko Hee‐SupShin Rodolfo R.Llinás | 2010 | The Journal of Physiology2010，，16： | 1 |
| 12 | Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial显示文摘 | Charles S Fuchs Jiri Tomasek Cho Jae Yong Filip Dumitru Rodolfo Passalacqua Chanchal Goswami Howard Safran Lucas Vieira dos Santos Giuseppe Aprile David R Ferry Bohuslav Melichar Mustapha Tehfe Eldar Topuzov John Raymond Zalcberg Ian Chau William Campbell | 2014 | The Lancet . 2014 (9911)2014，，9911： | 1 |
| 13 | Proteolytic activity in enzymatic extracts from Carica papaya L. cv. Maradol harvest by-products显示文摘 | Galindo-Estrella Thomás Hernández-Gutiérrez Rodolfo Mateos-Díaz Juan Sandoval-Fabián Georgina Chel-Guerrero Luis Rodríguez-Buenfil Ingrid Gallegos-Tintoré Santiago | 2008 | Process Biochemistry2008，，1： | 1 |
| 14 | A cold chain network for food exports to developing countries显示文摘 | Vietoria S Rodolfo M N | | 0，，10： | 1 |
| 15 | Improved experimental procedure for the synthesis of the potent MEK inhibi- tor PD184352 显示文摘 | NATALIA S RODOLFO M | 2005 | Synth Commun2005，35，17： | 1 |
| 16 | Effects of soil water deficit and nitrogen nutrition on water relations and photosynthesis of pot-grown coffee canephora Pierre显示文摘 | Fabio M D Rodolfo A L Emerson A S | 2002 | Trees2002，16，8： | 1 |
| 17 | CO oxidationon gold nanoparticles supported over titanium oxide nan-otubes显示文摘 | MAYIO M C JORGE R S RODOLFO Z | 2011 | Catalysis Today2011，166，： | 1 |
| 18 | Relationship marketing and information and communication technologies:Analysis of retail travel agencies显示文摘 | Leticia S A Ana M D M Rodolfo V C (2007) | 2007 | Journal of Travel Research2007，，： | 1 |
| 19 | AMH/MIS: what we know already about the gene, the protein and its regulation显示文摘 | Rodolfo Rey Céline Lukas-Croisier Celina Lasala Patricia Bedecarrás | 2003 | Molecular and Cellular Endocrinology2003，，1： | 1 |
| 20 | Marketing Orientation , Innovation and Competitive Strstegies in Industrial Firm 显示文摘 | Rodolfo V Maria L S | 2001 | Journal of Strategic Marketing2001，，9： | 1 |
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