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| 1 | Helicobacter pylori and corpus gastric pathology are associated with lower serum ghrelin显示文摘AIM To evaluate the association of Helicobacter pylori(H. pylori), cag A genotype, and type of gastric pathology with ghrelin, leptin and nutritional status.METHODS Fasted dyspeptic adults(18-70 years) referred for an upper digestive endoscopy were enrolled in this crosssectional study. Height and weight were assessed for body mass index(BMI) calculation. A sociodemographic survey was administered and nutrient intake was evaluated with 24 h dietary recalls. Serum total ghrelin and leptin levels were analyzed by enzymelinked immunosorbent assay. 13 C-Urea Breath Test was performed and four gastric biopsies were obtained during endoscopy for histopathology and H. pylori DNA amplification and genotyping. Data analysis was performed using χ2, Mann-Whitney U, Kruskal-Wallis tests, Spearman's correlation and linear regression.RESULTS One hundred and sixty-three patients(40.8 ± 14.0 years), 98/65 females/males, were included. Overall, persistent H. pylori prevalence was 53.4%(95%CI: 45.7%-65.8%). Neither nutrient intake nor BMI differed significantly between H. pylori positive and negative groups. Serum ghrelin was significantly lower in infected patients [median 311.0 pg/m L(IQR 230.0-385.5)] than in uninfected ones [median 355.0 pg/m L(IQR 253.8-547.8)](P = 0.025), even after adjusting for BMI and gender(P = 0.03). Ghrelin levels tended to be lower in patients carrying cag A positive strains both in the antrum and the corpus; however, differences with those carrying cag A negative strains did not reach statistical significance(P = 0.50 and P = 0.49, respectively). In addition, the type and severity of gastric pathology in the corpus was associated with lower serum ghrelin(P = 0.04), independently of H.pylori status. Conversely, leptin levels did not differ significantly between infected and uninfected patients [median 1.84 ng/m L(0.80-4.85) vs 1.84 ng/m L(0.50-5.09),(P = 0.51)]. CONCLUSION H. pylori infection and severity of gastric corpus pathology are associated with lower serum ghrelin. Further studies could confirm a lower ghrelin prevalence in cag A-positive patients. | Paula Mantero Gonzalo Sebastián Matus Rodolfo Ernesto Corti Ana María Cabanne Gerardo Gabriel Zerbetto de Palma Liliana Marchesi Olid María Marta Piskorz Marcela Beatriz Zubillaga Mariana Andrea Janjetic Cinthia Gabriela Goldman | 2018 | World Journal of Gastroenterology2018，24，3： | 8 |
| 2 | Effects of physiological integration on defense strategies against herbivory by the clonal plant Alternanthera philoxeroides显示文摘Aims The plant-herbivore interaction is one of the most fundamental inter-actions in nature.Plants are sessile organisms,and consequently rely on particular strategies to avoid or reduce the negative impact of herbivory.Here,we aimed to determine the defense strategies against insect herbivores in the creeping invasive plant Alternanthera philoxeroides.Methods We tested the defense response of A.philoxeroides to herbivory by a leaf-feeding specialist insect Agasicles hygrophila and a pol-yphagous sap-feeding insect Planococcus minor.We also tested the mechanisms triggering defense responses of A.philoxeroides by including treatments of artificial leaf removal and jasmonic acid application.Furthermore,we examined the effect of physiological integration on these defense strategies.Important Findings The combination of artificial leaf removal and jasmonic acid appli-cation produced a similar effect to that of leaf-feeding by the real herbivore.Physiological integration influenced the defense strat-egies of A.philoxeroides against herbivores,and increased biomass allocation to aboveground parts in its apical ramets damaged by real herbivores.Our study highlights the importance of physio-logical integration and modular plasticity for understanding the consequences of herbivory in clonal plants. | Rubén Portela Bi-Cheng Dong Fei-Hai Yu Rodolfo Barreiro Sergio R.Roiloa | 2019 | Journal of Plant Ecology2019，12，4： | 5 |
| 3 | PDX1.1-dependent biosynthesis of vitamin B6 protects roots from ammonium-induced oxidative stress显示文摘Despite serving as a major inorganic nitrogen source for plants,ammonium causes toxicity at elevated con-centrations,inhibiting root elongation early on.While previous studies have shown that ammonium-inhibited root development relates to ammonium uptake and formation of reactive oxygen species(ROS)in roots,it remains unclear about the mechanisms underlying the repression of root growth and how plants cope with this inhibitory effect of ammonium.In this study,we demonstrate that ammonium-induced apo-plastic acidification co-localizes with Fe precipitation and hydrogen peroxide(H_(2)O_(2))accumulation along the stele of the elongation and differentiation zone in root tips,indicating Fe-dependent ROS formation.By screening ammonium sensitivity in T-DNA insertion lines of ammonium-responsive genes,we identified PDX1.1,which is upregulated by ammonium in the root stele and whose product catalyzes de novo biosyn-thesis of vitamin B6.Root growth of pdx1.1 mutants is hypersensitive to ammonium,while chemical complementation or overexpression of PDX1.1 restores root elongation.This salvage strategy requires non-phosphorylated forms of vitamin B6 that are able to quench ROS and rescue root growth from ammo-nium inhibition.Collectively,these results suggest that PDX1.1-mediated synthesis of non-phosphorylated B6 vitamers acts as a primary strategy to protect roots from ammonium-dependent ROS formation. | Ying Liu Rodolfo A.Maniero Ricardo F.H.Giehl Michael Melzer Priscille Steensma Gabriel Krouk Teresa B.Fitzpatrick Nicolaus von Wirén | 2022 | Molecular Plant2022，15，5： | 3 |
| 4 | Effects of estrogen receptor modulators on cytoskeletal proteins in the central nervous system显示文摘Estrogen receptor modulators are compounds of interest because of their estrogenic agonistic/antagonistic effects and tissue specificity. These compounds have many clinical applications, particularly for breast cancer treatment and osteoporosis in postmenopausal women, as well as for the treatment of climacteric symptoms. Similar to estrogens, neuroprotective effects of estrogen receptor modulators have been described in different models. However, the mechanisms of action of these compounds in the central nervous system have not been fully described. We conducted a systematic search to investigate the effects of estrogen receptor modulators in the central nervous system, focusing on the modulation of cytoskeletal proteins. We found that raloxifene, tamoxifen, and tibolone modulate some cytoskeletal proteins such as tau, microtuble-associated protein 1(MAP1), MAP2, neurofilament 38(NF38) by different mechanisms of action and at different levels: neuronal microfilaments, intermediate filaments, and microtubule-associated proteins. Finally, we emphasize the importance of the study of these compounds in the treatment of neurodegenerative diseases since they present the benefits of estrogens without their side effects. | Julia J.Segura-Uribe Rodolfo Pinto-Almazán Angélica Coyoy-Salgado Claudia E.Fuentes-Venado Christian Guerra-Araiza | 2017 | Neural Regeneration Research2017，12，8： | 2 |
| 5 | Multi-objective optimization minimizing cost and life cycle emissions of stand-alone PV–wind–diesel systems with batteries storage显示文摘 | Rodolfo Dufo-López José L. Bernal-Agustín José M. Yusta-Loyo José A. Domínguez-Navarro Ignacio J. Ramírez-Rosado Juan Lujano Ismael Aso | 2011 | Applied Energy2011，，11： | 2 |
| 6 | Trans-generational effects in the clonal invader Alternanthera philoxeroides显示文摘近年的研究已经揭示出表型可塑性可以通过营养世代遗传。从这个意义上讲,环境诱导的基因调控变化(例如DNA甲基化,即表观遗传变异)会导致可逆的塑性反应传递给后代。这种跨世代的可塑性在克隆植物中尤其重要,因为有性繁殖减少会降低通过遗传变异进行适应的可能性。许多最具侵略性的植物入侵者都具有克隆性,而且克隆性被认为是植物入侵性的关键。本研究中,我们的目标是确定在克隆入侵者喜旱莲子草(Alternanthera philoxeroides)中是否发生了跨代效应,以及这种效应在本地和非本地群落之间是否存在差异。在同质园实验中,我们将采自巴西(原产地)和伊比利亚半岛(非原产地)的喜旱莲子草种群分别种植在养分高和低的土壤中,后代植株被移植到高养分条件下作为对照。为了检验DNA甲基化对跨代可塑性的潜在作用,一半的母株用去甲基化剂5-氮杂胞苷处理。在来自原产地和非原产地的种群中均观察到了跨代效应。有趣的是,在原产地种群的生长变量(分株数、茎生物量、根生物量和总生物量)中发现了跨代效应,而在非原产地种群中发现了生物量分配具有跨代效应。在原产地种群中出现的跨代效应可以用“银勺”效应来解释,而非原产地种群的跨代效应可以归因于DNA甲基化引起的表观遗传传递。本研究强调了跨代效应对克隆植物生长的重要性,这有助于理解众多克隆植物能够成功繁殖扩张的机制。 | Rubén Portela Bi-Cheng Dong Fei-Hai Yu Rodolfo Barreiro Sergio R.Roiloa Dalva MSilva Matos | 2020 | Journal of Plant Ecology2020，13，1： | 2 |
| 7 | Optimum residential load management strategy for real time pricing (RTP) demand response programs显示文摘 | Juan M. Lujano-Rojas Cláudio Monteiro Rodolfo Dufo-López José L. Bernal-Agustín | 2012 | Energy Policy2012，，： | 2 |
| 8 | The effects of brand associations on consumer response显示文摘 | A. Belén del Río Rodolfo Vázquez Víctor Iglesias | 2001 | Journal of Consumer Marketing2001，，5： | 2 |
| 9 | Isolation of ursolic acid from apple peels by high speed counter-current chromatography显示文摘 | Rosa T Rodolfo M Eduardo N | 2008 | Food Chemistry2008，106，： | 1 |
| 10 | Morphology and sedimentology of two contemporary fan deltas on the southeastern Baja California Peninsula, Mexico显示文摘 | Enrique N S Rodolfo C O Donn S G | 1995 | Sedimentary Geology1995，98，： | 1 |
| 11 | Pathophysiologic Mechanisms of Cardiovascular Disease in Obstructive Sleep Apnea Syndrome显示文摘 | Carlos Zamarrón Luis Valdés Cuadrado Rodolfo álvarez-Sala Francisco García Río | 2013 | <journal-title>Pulmonary Medicine2013，，： | 1 |
| 12 | Theoretical and experimental insights on the true impact of C 12 TAC cationic surfactant in enhanced oil recovery for heavy oil carbonate reservoirs显示文摘 | Mirna Pons-Jiménez Rocío Cartas-Rosado José Manuel Martínez-Magadán Raúl Oviedo-Roa Rodolfo Cisneros-Dévora Hiram I. Beltrán Luis S. Zamudio-Rivera | 2014 | Colloids and Surfaces A: Physicochemical and Engineering Aspects2014，，： | 1 |
| 13 | Proteolytic activity in enzymatic extracts from Carica papaya L. cv. Maradol harvest by-products显示文摘 | Galindo-Estrella Thomás Hernández-Gutiérrez Rodolfo Mateos-Díaz Juan Sandoval-Fabián Georgina Chel-Guerrero Luis Rodríguez-Buenfil Ingrid Gallegos-Tintoré Santiago | 2008 | Process Biochemistry2008，，1： | 1 |
| 14 | A cold chain network for food exports to developing countries显示文摘 | Vietoria S Rodolfo M N | | 0，，10： | 1 |
| 15 | Hourly energy management for grid-connected wind–hydrogen systems显示文摘 | José L. Bernal-Agustín Rodolfo Dufo-López | 2008 | International Journal of Hydrogen Energy2008，，22： | 1 |
| 16 | Design and control strategies of PV-Diesel systems using genetic algorithms显示文摘 | Rodolfo Dufo-López José L. Bernal-Agustín | 2004 | Solar Energy2004，，1： | 1 |
| 17 | Application of formal languages in polynomial transformations of instances between NP-complete problems显示文摘We propose the usage of formal languages for expressing instances of NP-complete problems for their application in polynomial transformations. The proposed approach, which consists of using formal language theory for polynomial transformations, is more robust, more practical, and faster to apply to real problems than the theory of polynomial transformations. In this paper we propose a methodology for transforming instances between NP-complete problems, which differs from Garey and Johnson's. Unlike most transformations which are used for proving that a problem is NP-complete based on the NP-completeness of another problem, the proposed approach is intended for extrapolating some known characteristics, phenomena, or behaviors from a problem A to another problem B. This extrapolation could be useful for predicting the performance of an algorithm for solving B based on its known performance for problem A, or for taking an algorithm that solves A and adapting it to solve B. | Jorge A. RUIZ-VANOYE Joaquín PREZ-ORTEGA Rodolfo A. PAZOS RANGEL Ocotlán DíAZ-PARRA Héctor J. FRAIRE-HUACUJA Juan FRAUSTO-SOLíS Gerardo REYES-SALGADO Laura CRUZ-REYES | 2013 | Journal of Zhejiang University-Science C(Computers and Electronics)2013，14，8： | 1 |
| 18 | Determinants of food away from home consumption:An update显示文摘 | Rodolfo M N Oral C | 1992 | Agribusiness1992，8，6： | 1 |
| 19 | Paleomagnetism of Palawan,Philippines显示文摘 | Almasco J N Rodolfo K Fuller M | 2000 | Journal of Asian Earth Sciences2000，18，： | 1 |
| 20 | Microsatellite analysis of the parental contribution of Piaractus mesopo- tamicus to the production of offspring in the semi-natural system of Reproduction显示文摘 | Jayme A P Ricardo P R Rodolfo N S | 2010 | Braz Arch Biol Technol2010，53，： | 1 |
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