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	题名	作者	年代	出处	被引量
1	Multicriteria optimization with a multiobjective golden section line search显示文摘	Douglas A G V Ricardo H C T Rodney R S	2012	Mathematical Programming2012，131，12：	1
2	Fermentation of hexose and pentose sugars using a novel ethanologenic Escherichia coli strain显示文摘	Robert B H Herbert A W Rodney J B	1998	Enzyme and Microbial Technology1998，23，：	1
3	Company-wide Project Management: The Planning and Control of Programmes of Projects of Different Type 显示文摘	JOHN H P J RODNEY T	1999	International Journal of Project Management1999，17，1：	1
4	Role of trace element in nutrition:Metabolism,essentiality and dietary considerations显示文摘	Rodney J F Peter J H	1993	Life Science1993，52，4：	1
5	Determination of carbendazim in blue berries by reversed phase high 2 perfomance liquid chromatography显示文摘	Rodney J B Heather L H Jasotha K	1991	Journal of Chromatography1991，，587：	1
6	Intranasal vaccination with ISCOMATRIX adjuvanted influenza vaccine显示文摘	Alan C Rodney H Roslyn D	2003	Vaccine2003，21，2：	1
7	Disease-specific health status after stent-assisted percutaneous coronary intervention and coronary artery bypass surgery:one-year results from the stent or surgery trial显示文摘	Zhang ZE Mmahoney ES Rodney H	2003	Circulation2003，108，14：	1
8	Modeling alkaline silicate solution at 25 ℃ 显示文摘	WEBER C F RODNEY D H	2003	Ind Eng Chem Res2003，42，26：	1
9	Soluble single-walled carbon nanotubes as longboat delivery systems for platinum (IV) anticancer drug design显示文摘	RODNEY P F NOZOMI N R DAI H J	2007	Journal of the American Chemical Society2007，129，27：	1
10	Microscopic NickelZinc Batteries For Use in Autonomous Microsystems显示文摘	Paul H Humbl John Harb Rodney LaFollette	2001	ECS2001，148，12：	1
11	Determination of carbendazim in blue berries by reversed phase high-performance liquid chromatography显示文摘	Rodney J B Heather L H Jasotha K	1991	Journal of Chromatography1991，，587：	1
12	Environmentally Critical Elements in Channel and Cleaned Samples of Illinois Coals显示文摘	Iiham D Rodney R R Heinz H D Richard D H John D S Ken K H	1998	Fuel1998，，77：	1
13	Regional osteoporosis in women who have a complete spine cord injury显示文摘	Garland Rodney H	2001	J Bone Surg2001，83，：	1
14	Ribosomal RNA in vertebrates:Evoltion and phylogentie applications显示文摘	David P M Rodney L H	1990	Armu Rev Eeol Syst1990，21，1：	1
15	Natural epitope variants of the hepatitis C virus impair cytotoxic T lymphocyte activity显示文摘AIM:To understand how interactions between hepatitis C virus(HCV) and the host's immune system might lead to viral persistence or effective elimination of HCV.METHODS:Nucleotides 3519-3935 of the non-structural 3(NS3) region were amplified by using reverse transcription polymerase chain reaction(PCR).PCR products of the HCV NS3 regions were integrated into a PCR T7TOPO TA vector and then sequenced in both directions using an automated DNA sequencer.Relative major histocompatibility complex binding levels of wild-type and variant peptides were performed by fluorescence polarization-based peptide competition assays.Peptides with wild type and variant sequences of NS3 were synthesized locally using F-moc chemistry and purified by high-performance liquid chromatography.Specific cytotoxic T lymphocytes(CTLs) clones toward HCV NS3 wild-type peptides were generated through limiting dilution cloning.The CTL clones specifically recognizing HCV NS3 wild-type peptides were tested by tetramer staining and flow cytometry.Cytolytic activity of CTL clones was measured using target cells labeled with the fluorescence enhancing ligand,DELFIA EuTDA.RESULTS:The pattern of natural variants within three human leukocyte antigen(HLA)-A2-restricted NS3 epitopes has been examined in one patient with chronic HCV infection at 12,28 and 63 mo post-infection.Results obtained may provide convincing evidence of immune selection pressure for all epitopes investigated.Statistical analysis of the extensive sequence variation found within these NS3 epitopes favors a Darwinian selection model of variant viruses.Mutations within the epitopes coincided with the decline of CTL responses,and peptide-binding studies suggested a signif icant impact of the mutation on T cell recognition rather than peptide presentation by HLA molecules.While most variants were either not recognized or elicited low responses,such could antagonize CTL responses to target cells pulsed with wild-type peptides.CONCLUSION:Cross-recognition of CTL epitopes from wild-type and naturally-occurring HCV variants may lead to impaired immune responses and ultimately contribute to viral persistence.	Shuping Wang Rico Buchli Jennifer Schiller Jianen Gao Rodney S VanGundy William H Hildebrand David D Eckels	2010	World Journal of Gastroenterology2010，16，16：	1
16	Determination carbendazim in blue berries by reversed phase high-performance liquid hromatography显示文摘	RODNEY J B HEATHER L H JASOTHA K	1991	Journal of Chromatography1991，，587：	1
17	Determination of Carbendazim in Blue Beries by Reversed Phase High-performance Liquid Chroma-tography显示文摘	RODNEY J B HEATHER L H JASOTHA K	1991	J Chromatography1991，，587：	1
18	Thoracoscopic resection of mediastinal cyst显示文摘	Stephen R H Rodney J L Michael J M	1993	Ann Thorac Surg1993，56，：	1
19	Sialic acid glycoproteins inhibit in vitro and in vivo replication of rotaviruses显示文摘	ROBERT H Y RODNEY W SIOK-BI W	1987	J Clin Invest1987，79，：	1
20	A Comparative Analysis of Interna- tional Education Satisfaction Using SERVQUAL显示文摘	RODNEY A JOHN H	2006	Journal of Services Research2006，6，：	1

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