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| 1 | Prophylaxis with ketotifen in rats with portal hypertension:involvement of mast cell and eicosanoids显示文摘BACKGROUND:Since we have previously shown an increase of mast cells in the small bowel and in the mesenteric lymph nodes in the rats with prehepatic portal hypertension,it can be hypothesized that this essential inflammatory cell would be involved in the pathogeny of the splanchnic changes related to portal hypertension. METHODS:To verify this hypothesis,we first studied mast cell infiltration in the ileum and in the mesenteric lymph nodes in sham-operated male Wistar rats(n=12) and in short-term prehepatic portal hypertensive rats (n=12),and the serum levels of rat mast cell protease Ⅱ(RMCP-Ⅱ)by ELISA.In a second set of experiments ketotifen,a mast cell stabilizer drug,was administered to sham-operated(n=10)and portal hypertensive(n=12) rats 24 hours before the intervention and prostanoids (PGE2,PGI2,TXB2)and leukotrienes(LTC4,LTB4)were assayed by RIA,mast cell infiltration in the ileum and in the mesenteric lymph nodes and the serum levels of RMCP-Ⅱwere also studied,to show its effectiveness to prevent the mesenteric alterations produced by the inflammatory mediators released by the mast cell. RESULTS:Forty-eight hours after the intervention RMCP-Ⅱ (P<0.05),PGE2(P<0.001)and LTC4 serum levels decreased and mast cell number and RMCP-Ⅱlevels increased in mesenteric lymph nodes in portal hypertensive rats.Prophylactic administration of ketotifen reduced portal pressure(P<0.001),serum levels of PGE2(P<0.001)and RMCP-Ⅱ(P<0.001)in mesenteric lymph nodes. CONCLUSIONS:In acute portal hypertension in the rat,the mast cell translocation from intestinal mucosa to mesenteric lymph nodes,where they are activated and degranulates,would represent a defence mechanism to avoid the activation of an acute and massive inflammatory response in this location.Prophylactic administration of ketotifen is able to reduce the splanchnic inflammatory changes related to acute portal hypertension in the rat. | Fernando Sánchez-Patán Raquel Anchuelo Elena Vara Cruz García Yolanoa Saavedra Patri Vergara Carmen Cuellar Marta Rodero Maria-Angeles Aller Jaime Arias | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 2 | Late Quaternary seismic faces of the Gulf of Cadiz Spanish margin: depositional processes influenced by sea-level change and tectonic controls 显示文摘 | Rodero J Pallares L Maldinado A | 1999 | Marine Geology1999，155，： | 1 |
| 3 | Assessment of a new carbon tetrachloride destruction system based on a microwave plasma torch operating at atmospheric pressure 显示文摘 | Rubio S J Quintero M C Rodero A | 2007 | Journal of Hazardous Materials2007，148，12： | 1 |
| 4 | Genetic structure of the Iberian pig breed using microsateUites显示文摘 | MARTINEZ A M DELGADO J V RODERO A | 2000 | Anita Genet2000，31，5： | 1 |
| 5 | Genetic structure of the Iberian pig breed using mierosatellites 显示文摘 | MARTINEZ A M DELGADO J V RODERO A | 2000 | Anita Genet2000，31，： | 1 |
| 6 | Genetic influence of the nonclassical major histocompatibility complex class I molecule M I CB in multiple sclerosis susceptibility 显示文摘 | Fernandez -Morera J L Rodriguez - Rodero S Tunon A | 2008 | Tissue Antigens2008，72，1： | 1 |
| 7 | Genetic structure of the Iberian pig breed using microsatellites显示文摘 | Martinez A M Delgado J V Rodero A | 2000 | Anim Genet2000，31，： | 1 |
| 8 | Anisakis simplex: The high prevalence in Madrid (Spain)and its relation with fish consumption 显示文摘 | PUENTE P ANADON A M RODERO M | 2008 | Experimental Parasitology2008，118，： | 1 |
| 9 | Genetic struc- ture of the Iberian pig breed using microsatellites显示文摘 | Martinez A M Delgado J V Rodero A | 2000 | Animal Genetics2000，31，5： | 1 |
| 10 | Fungal contamination of potential medical interest in Spanish grain stores显示文摘 | Mediavilla Molina A Angulo Romero J Rodero Franganillo J M | 1996 | J Investig Allergol Clin Immunol1996，6，3： | 1 |
| 11 | Genetic structure of Iberian pig breed using microsatellite s 显示文摘 | Martinez A M Delgado J V Rodero A | 2000 | Anim Genet2000，31，： | 1 |
| 12 | Genetic structure of the Iberian pig breed using microsatellites 显示文摘 | Martinez A Z Delgado J V Rodero A | 2000 | Anim Genet2000，30，： | 1 |
| 13 | Factors controlling phosphorus speciation in a Mediterranean basin (River Guadalfeo, Spain) 显示文摘 | Avil S A Rodero J Amores V | 2006 | Journal of Hydrology2006，331，34： | 1 |
| 14 | Order in choice effects of serial position on preferences显示文摘 | MANTONAKIS A’RODERO P LESSCHAEVE I | 2009 | Psychological Science2009，20，11： | 1 |
| 15 | Cloud federation in a layered service model显示文摘 | Villegas D Bobroff N Rodero I Delgado J Liu Y Devarakonda A Fong L Masoud Sadjadi S Parashar M | 2012 | Journal of Computer and System Sciences2012，78，5： | 1 |
| 16 | A break in the clouds: towards a cloud definition 显示文摘 | VAQUERO L M RODERO M L CACERES J et a/ | 2009 | ACM SIGCOMM Com- puter Communication Review2009，39，1： | 1 |
| 17 | Evaluation by ELISA of Anisakis simplex larval antigen purified by affinity chromatography显示文摘 | RODERO M JIMENEZ A CUELLAR C | 2002 | Mem Inst Oswaldo Cruz Rio de Janeiro2002，97，2： | 1 |
| 18 | Genetic structure of the Iberian pig breed using microsatellites 显示文摘 | MARTINEZ A Z DELGADO J V RODERO A | 2000 | Anim Genet2000，31，5： | 1 |
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