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| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | CD133,a novel marker for human prostatic epithelial stem cells显示文摘 | Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T | 2004 | J Cell Sci2004，117，16： | 1 |
| 3 | Surgical and nonsurgical manage- ment of lumbar spinal stenosis: four - year outcomes from the Maine lumbar spine study显示文摘 | Atlas S J Keller RB Robson D | 2000 | Spine2000，25，： | 1 |
| 4 | Adaptation of the maternal heart in pregnancy显示文摘 | Hunter S Robson SC | 1992 | Br Heart J1992，68，6： | 1 |
| 5 | Surgical and nonsurgi cal management of lumber spinal stenosis:four-year outcomes from the maine lumbar spine study显示文摘 | Atlas S J Keller R B Robson D | 2000 | Spine2000，25，5： | 1 |
| 6 | Making sense of regulatory T cell suppressive function显示文摘 | Shalev I Schmelzle M Robson S C | | 0，，04： | 1 |
| 7 | Catch curves andmoritality rates显示文摘 | ROBSON D S CHPMNA D G | 1961 | Trans Am Fish Soc1961，90，： | 1 |
| 8 | Changes inplant mitochondrial electron transport alter cellular levels of reac-tive oxygen species and susceptibility to cell death signaling mole-cules显示文摘 | Amirsadeghi S Robson C A McDonald A E | 2006 | Plant Cell physiol2006，47，11： | 1 |
| 9 | Interpenetrating nets: ordered,periodic entanglement显示文摘 | BATTEN S R ROBSON R | 1998 | Angew Chem Int Ed1998，37，11： | 1 |
| 10 | A micronetralization test for canine distemper virus显示文摘 | Appel M Robson D S | | 0，，： | 1 |
| 11 | Leaf senescence is delayed in maize expressing the Agrobacterium IPT gene under the control of a novel maize senescence-enhanced promoter 显示文摘 | ROBSON P R H DONNISON I S WANG K | 2004 | Plant Biotechnology Journal2004，，2： | 1 |
| 12 | Inhibition of baboon plate aggregation in vitro and in vivo by the garlic derivative, ajoene显示文摘 | TERANISHI K APITZ-CASTRO R ROBSON S C | 2003 | Xenotransplantation2003，10，2： | 1 |
| 13 | Effects of interleukin-6 on extravillous trophoblast invasion in early hu- man pregnancy 显示文摘 | CHAMPION H INNES B A ROBSON S C | 2012 | Mol Hum Reprod2012，18，8： | 1 |
| 14 | Making sense of regulatory T cell suppressive function显示文摘 | Shalev I Schmelzle M Robson S C | 2011 | Semin Immunol2011，23，4： | 1 |
| 15 | Attenuation of virus diarrhea virus(strain Oregon C24V) for vaccine purposes显示文摘 | COGGINS L GILLESPIE J H ROBSON D S | 1961 | Cornell Vet1961，54，： | 1 |
| 16 | Nucleation and crystallization in Fe-S and Fe-Cr containing glass-ceramies based slag 显示文摘 | Davies M W Hazeldean G S F Robson M J | 1970 | Science of Ceramics1970，，5： | 1 |
| 17 | Cloning and expression of the thrombospondin related adhesive protein gene of Plasmodium bergheil显示文摘 | ROBSON KJ NAITZA S BARKER G | 1997 | Mol Biochem Parasitol1997，84，1： | 1 |
| 18 | Programming the offspring of the pig by prenatal social stress : neuroendocrine activity arid Behaviour 显示文摘 | JARVIS S MOINARD C ROBSON S K | 2006 | Homones and Behavior2006，49，1： | 1 |
| 19 | Leaf senescence is delayed in maize expressing the Agrobacterium IPT gene under the control of a novel maize senescence-enhanced promoter显示文摘 | Robson P R Donnison I S Wang K | | 0，，2： | 1 |
| 20 | The photopic negative response of the macaque electroretinogram is reduced by experimental glaucoma显示文摘 | Viswanathan S Frishman LJ Robson JG | 1999 | Invest Ophthalmol Vis Sci1999，40，6： | 1 |
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