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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | The association of Chlamydia pneumoniae infection and reactive airway disease in children显示文摘 | Emre U Roblin PM Gelling M | 1994 | Arch Pediatr Adolesc Med1994，148，7： | 1 |
| 3 | In vitro activity of a new antibiotic, NVP-PDF386 (VRC4887), against Chlamydia pneumoniae 显示文摘 | Roblin P M Hammerschlag M R | 2003 | Antimicrob Agents Chemother2003，47，4： | 1 |
| 4 | The association of Chlamydia pneumoniae infection and reactive airway disease in children显示文摘 | Emre U Roblin PM Gelling M | 1994 | Arch Pediat Adolesc Med1994，148，： | 1 |
| 5 | Migration of an intra uterine device into the bladder显示文摘 | Ceccato V Boileau A Roblin M | 2007 | Progres En Urologic2007，17，2： | 1 |
| 6 | The association of Chlamydia pneumoniae infection and reactive airway disease in children显示文摘 | Emre U Roblin PM Gelling M | 1994 | Arch Pediatr Adolesc Med1994，148，7： | 1 |
| 7 | Use of polymerase chain reaction for the detection of Chlamydia trachomatis in ocular and nasopharyngeal specimens from infants with conjunctivitis显示文摘 | Hammerschlag MR Roblin PM Gelling M | 1997 | Pediatr Infect Dis J1997，16，3： | 1 |
| 8 | Infection with Chlamydiae Pneumoniae in Brook lyn显示文摘 | Chirgw in K Roblin P M Gelling M | 1991 | J Infect Dis1991，163，： | 1 |
| 9 | Use of Hep-2 cells for improved isolation and passage of Chlamydia pneumoniae显示文摘 | Roblin P M Dumornay W Hammerschlag M R | 1992 | J Clinic Microbiol1992，30，8： | 1 |
| 10 | Use of Hep-2 cells for improved isolation and passage of Chlamydia pneumoniae显示文摘 | Roblin P M Dumornay W Hammerschlag M R | 1992 | J Clin Microbiol1992，30，8： | 1 |
| 11 | The long acting GLP-1 derivative NN2211 ameliorates glycemia and increases beta-cell mass in diabetic mice显示文摘 | Roblin B Larsen M Gotfredsen C | 2002 | Am J Physiol Endocrinol Metab2002，283，4： | 1 |
| 12 | Infection with chlamydia pneumoniae in Brooklyn显示文摘 | Chirgwin K Roblin PM GeUing M | 1991 | J Infect Dis1991，163，4： | 1 |
| 13 | Effect of increased cost-sharing on oral hypoglycemic use in five managed care organizations-How much is too much? 显示文摘 | Roblin D W Platt R Goodman M J | 2005 | Medical Care2005，43，10： | 1 |
| 14 | In vitro activity of a new antibiotic NVP-PDF386 (VRC4887) against Chlamydia pneumoniae 显示文摘 | ROBLIN P HAMMERSCHLAG M | 2003 | Antimicrob Agents Chemother2003，47，4： | 1 |
| 15 | Hyperhomocysteinaemia is associated with osteoporosis in patients with Crohn's disease显示文摘 | Phelip JM Genevois M | 2007 | Aliment Pharmacol Ther2007，25，7： | 1 |
| 16 | Health literacy and cancer prevention:Two new instruments to assess comprehension 显示文摘 | Mazor K M Roblin D W Williams A E | 2012 | Patient education and counseling2012，88，1： | 1 |
| 17 | The association of Chlamydia pneumoniae infection and reactive airway disease in children 显示文摘 | Emre U Roblin P Gelling M | 1994 | Arch Pediatr Adolese Med1994，148，： | 1 |
| 18 | Fourier transform holography using a quasimonochromatic incoherent source显示文摘 | S Mallick M L Roblin | 1971 | Appl Opt1971，10，3： | 1 |
| 19 | Biermer′s anemia:a new cause of cholestasis and hepatic steatosis显示文摘 | Roblin X Genevois M Ducros V | 2007 | Dig Dis Sci2007，52，12： | 1 |
| 20 | Treatment of neonatal chlamydial conjunctivitis with azithromycin 显示文摘 | Hammerschlag MR Gelling M Roblin PM | 1998 | Pedi- atr Infect Dis J1998，17，11： | 1 |
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