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| 1 | Liver immunology and its role in inflammation and homeostasis显示文摘当一个非免疫学的机关首先从事了新陈代谢的、滋养的存储和 detoxification 活动,人的肝通常被察觉。然而,我们现在知道健康的肝也是复杂免疫学的一个地点活动象非造血的房间人口一样由一个多样的有免疫力的房间全部剧目调停了。在疾病得非的肝,新陈代谢并且织物改变功能要求发炎的元素。在有到饮食、微生物引起的产品的常规暴露的联合,这发炎为过多的有免疫力的激活创造潜力。在这复杂微型环境,肝的免疫系统容忍无害的分子当同时对可能的传染代理人仍然保持警惕时,恶意的房间或纸巾损坏。在到由病原体或织物损坏的挑战的适当有免疫力的激活之上,解决发炎的机制是必要的维持肝动态平衡。清除 ‘ 的失败; dangerous’刺激或调整适当地激活的有免疫力的机制导致病理学的发炎和纤维变性,肝硬化和最终的肝失败的进步发展描绘的破坏织物动态平衡。肝的煽动性的机制因此在健康的成年的肝有角色的一个系列;他们是必要的维持织物和机关动态平衡并且 dysregulated,肝病理的关键司机与长期的感染, autoimmunity 和恶意被联系。在这评论,我们在正常的肝动态平衡探索发炎和煽动性的调停人的变化感觉并且求婚作为一条治疗学的途径肝特定的有免疫力的规定小径指向治疗肝疾病。 | Mark W Robinson Cathal Harmon Cliona O'Farrelly | 2016 | Cellular & Molecular Immunology2016，13，3： | 65 |
| 2 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 3 | CMOS micromachined low power microlamp vacuum sensor显示文摘 | MA Y ROBINSON A M LAWSON R P W | 2002 | IEEE2002，，： | 2 |
| 4 | Precipitation in vanadium bearing uhralow carbon strip steels 显示文摘 | S W Ooi G Fourlaris D A Tanner J S Robinson | 2006 | Materials Science and Technology2006，22，5： | 1 |
| 5 | Psychological Contracts and OCB:the Effect of Unfulfilled Obligations on Civic Virtue Behavior显示文摘 | Robinson S L Morrison E W | 1995 | Journal of Organizational Behavior1995，，16： | 1 |
| 6 | Psychological contracts and OCB: the effect of unfulfilled obligations on civic virtue behavior显示文摘 | Robinson S L &Morrison E W | 1995 | Journal of Applied Psychology1995，16，： | 1 |
| 7 | Retrovirus expressed hemagglutinin pro-tects against lethal influenza virus infections显示文摘 | Hunt L A Brown D W Robinson H L | 1988 | J Virol1988，，62： | 1 |
| 8 | New frontiers in food enzymology: recombinant lipoxygenases显示文摘 | Casey R West S I Hardy D David S Robinson Zecai W u Richard K Hughes | 1999 | Trends in Food Science & Technology1999，10，： | 1 |
| 9 | Levels of five mycotoxins in grains harvested in Atlantic Canada as measured by high performance liquid chromatography 显示文摘 | STRATTON G W ROBINSON A R SMITH H C | 1993 | Arch Environm Contam Toxicol1993，24，： | 1 |
| 10 | DNA methylation changes in whole blood is associated with exposure to the environmental contaralna nts, mercury, lead, cadmium and bisphenol A, in women undergoing ovarian stimulation for IVF 显示文摘 | Hanna C W Bloom M S Robinson W P | 2012 | Human Reproduction2012，27，： | 1 |
| 11 | Phylogenetics of Pi-nus (Pinaceae) based on nuclear ribosomal DNA internal tran-scribed spacer region sequences 显示文摘 | Liston A Robinson W A Piriero D | 1999 | Molecular Phylogenetics &Evolution1999，11，1： | 1 |
| 12 | Photosynthetic and stomatal responses of spinach leaves to salt stress显示文摘 | DOWNTON W J S GRANT W J R ROBINSON S P | 1985 | Plant Physiology1985，78，1： | 1 |
| 13 | Thermal surface fouling of cvaporator显示文摘 | McCabe W L Robinson C S | 1924 | Chem Eng1924，20，16： | 1 |
| 14 | Factors cantrolling prolific gas production from low-permeability sandstone reservoirs:Implications for resource assessment,prospect development,and risk analysis显示文摘 | Shanley K W Cluff R M Robinson J W | 2004 | AAPG Bulletin2004，88，8： | 1 |
| 15 | Plants secrete substances that mimic bacterial N-acyl homoserine lactone signal activities and affect population density-dependent behaviors in associated bacteria显示文摘 | Teplitski M Robinson J B Bauer W D | 2000 | Mol Plant Microbe Interact2000，13，6： | 1 |
| 16 | Submemed macrophytes and the hydraulic reushhess of a lowland chalkstream显示文摘 | DAWSON F H ROBINSON W N | 1984 | Verhandlung Internationale Vereinigung Limnologie1984，，22： | 1 |
| 17 | An extrusion energy absorber suitable for the protection of structures during an earthquake显示文摘 | Robinson W H Greenbank L R | 1976 | Earthquake Engineering &Structural Dynamic1976，4，3： | 1 |
| 18 | Categories of matrices with only obvious Moore-Penrose inverse显示文摘 | Robinson D W Puystjens R Van Geel J | 1987 | Linear Algebra Appl1987，97，： | 1 |
| 19 | The existence of multiple solutions for the laminar flow in a uniformly porous channel with suction at both walls显示文摘 | Robinson W A | 1976 | Journal of Engineering Mathematics1976，10，1： | 1 |
| 20 | The predictive value of LEEP speciments with involved margins for residual dysplasia显示文摘 | Robinson W R Tirpack J S | 1996 | Int J Gynecol Cancer1996，6，： | 1 |
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