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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Dectin-2 is a Syk coupled pattern recognition receptor crucial for Th17 responses to fungal infection显示文摘 | Robinson MJ Osorio F Rosas M | 2009 | The Journal of experimental medicine2009，206，9： | 1 |
| 3 | High-chromium and high-alu minum podiform chromitites,western china:relationship to partial melting and melt/rock interaction in the upper mantle 显示文摘 | Zhou M F Robinson P T | 1994 | Intel Geol Rev1994，36，： | 1 |
| 4 | A temporal link between the Emeishan large igneous province (SW China) and the end-Guagalupian mass extinction 显示文摘 | Zhou M F Malpas J Song X Y Robinson P T Sun M Kennedy A K Lesher C M Keays R R | 2002 | Earth arut Planetary Science Letters2002，196，： | 1 |
| 5 | Triazole induced concentration-related gene signatures in rat whole embryo culture 显示文摘 | Robinson J F Tonk E C Verhoef A | 2012 | Reproductive Toxicology2012，34，： | 1 |
| 6 | Conservation and variation in off virus genomes显示文摘 | Barns G F raser K | 1987 | Virology1987，157，1： | 1 |
| 7 | Submemed macrophytes and the hydraulic reushhess of a lowland chalkstream显示文摘 | DAWSON F H ROBINSON W N | 1984 | Verhandlung Internationale Vereinigung Limnologie1984，，22： | 1 |
| 8 | Fluvastatin and lovastatin inhibit granulocyte macrophage-colony stimulating factor-stimulated human eosinophil adhesion to inter-cellular adhesion molecule-1 under flow conditions显示文摘 | Robinson AJ Kashanin D O'Dowd F | 2009 | Clin Exp Allergy2009，39，12： | 1 |
| 9 | Sampling prac- tices in powder blending 显示文摘 | Muzzio F J Robinson P Wightman C | 1997 | International Journal of Pharma- ceutics1997，155，： | 1 |
| 10 | Data assimilation via error subspace statistical estimation Part Ⅰ: theory and schemes 显示文摘 | Lermusiaux P F J Robinson A R | 1999 | Monthly Weather Review1999，127，7： | 1 |
| 11 | Strontium 89 therapy for the palliation of pain due to osseous metastases显示文摘 | Robinson R G Preston D F Schiefelbein M | 1995 | JAMA1995，274，5： | 1 |
| 12 | Concentration of two 1, 4- benzoxazinones in dent corn at various stages of develop- ment of the plant and its relation to resistance of the host plant to the European Corn borer 显示文摘 | KLUN J A ROBINSON J F | | Journal of Econom- ic Entomology0，62，1： | 1 |
| 13 | A heuristic for packing boxes into a con- tainer显示文摘 | eorge J A Robinson D F | 1980 | Computers and Operations Research1980，7，3： | 1 |
| 14 | Evaluation of neonic-otinoid,organophosphate and avermectin trunk injections for themanagement of avocado thrips in California avocado groves 显示文摘 | Byrne F J Urena A A Robinson L J | 2012 | Pest Management Science2012，68，5： | 1 |
| 15 | Real-world automotive emissions-summary of studies in the Fort McHenry and Tuscarora Mountain Tunnels显示文摘 | Pierson W R Gertler A W Robinson N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 16 | The United Kingdom Children's Cancer Study Group's second germ cell tumor study: carboplatin, etoposide, and bleomycin are effective treatment for children with malignant extracranial germ cell tumors, with acceptable toxicity 显示文摘 | Mann J R Raafat F Robinson K | 2000 | J Clin Oncol2000，18，22： | 1 |
| 17 | Real world automotive emissions-a summary of studies in the Fort McHemy andTuscarora Mountain Tunnels 显示文摘 | PIERSON W R GERTLER A W ROBINSON N F | 1996 | Atmospheric Environment1996，30，12： | 1 |
| 18 | Developmental change in the voltage- dependence of the pacemaker current, If, in rat ventricle cells 显示文摘 | Robinson RB Yu H Chang F | 1997 | Plugers Arch1997，433，4： | 1 |
| 19 | Amino acid nutrition and immune function in tumour-bearing rats:a comparison of glutamine-,arginine-and ornithine 2-oxoglutarate-supplemented diets显示文摘 | Robinson L E Bussiere F I Le Boucher J | 1999 | Clin Sci (Lond)1999，97，： | 1 |
| 20 | Mitogen-activated protein (MAP) kinase pathway:regulation and physiological funcdons显示文摘 | Pearson G Robinson F Beers Gibson T | 2001 | Endocr Rev2001，22，： | 1 |
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