5篇
您的检索式：作者名="Robert ASA"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The molecular physiology and pathology of fibrin structure/function 显示文摘 | Kristina FS Robert ASA Peternity JG | 2005 | Blood Reviews2005，，： | 1 |
| 2 | Mouse models for rheumatoid arthritis 显示文摘 | Anna-Karin B L Robert B Asa C M | 2002 | Trends Genet2002，18，6： | 1 |
| 3 | Bcl-2 family members and apoptosis,taken to heart显示文摘 | Asa BG Robert AG | 2007 | Am physiol Cell Physiol2007，292，1： | 1 |
| 4 | Surrogate potency assays:Comparison of binding profiles complements dose response curves for unambiguous assessment of relative potencies显示文摘Surface plasmon resonance(SPR) systems are widely used for detailed characterization of antibody activities including antigen and Fc-receptor binding. During the later stages of development, where the focus is to ensure that established critical quality attributes(CQAs) are maintained during cell culture,purification and formulation processes, analysis is simplified, and relative potencies are often determined. Here, simulation of binding data revealed that relative potency values, determined via parallel line analysis(PLA) and half maximal effective concentration(EC50) analysis accurately reflect changes in active concentration only if binding kinetics remain unchanged. Changes in the association rate constant shifted dose response curves, and therefore relative potencies, in the same way as changes in analyte concentration do. However, for interactions characterized by stable binding, changes in the dissociation rate constant did not result in any shift, suggesting that this type of change may go unnoticed in the dose response curve. Thus, EC50 and PLA analyses of dose response curves obtained with an anti-TNF-α antibody were complemented with the Biacore functionality for sensorgram comparison analysis, whereby changes in antigen and Fc-receptor binding profiles could be detected. Next, analysis of temperature stressed TNF-α antibody revealed that calibration free concentration analysis(CFCA) data correlated perfectly with relative potency values. Together, these results demonstrate that combinations of SPR based dose response curves, sensorgram comparison and CFCA can be used to strengthen the confidence in relative potency assessments, and suggest that SPR can potentially be used as a surrogate potency assay in the quality control of biotherapeutic medicines. | Robert Karlsson Veronica Fridh Asa Frostell | 2018 | Journal of Pharmaceutical Analysis2018，8，2： | 0 |
| 5 | 产前和产后双酚A暴露和童年体质指数显示文摘[背景]双酚A(BPA)是一种广泛使用的内分泌干扰化学物,与啮齿类动物体重增加和脂肪沉积有关联。[目的]在CHAMACOS纵向队列的9岁儿童组(n=311)中,研究产前和产后尿BPA浓度与体质指数(BMI)、腰围、体脂肪率和肥胖间的关联。[方法]采集母亲怀孕期间现场收集的两次尿样以及5岁和9岁儿童的尿样,测量BPA浓度。[结果]产前尿BPA浓度与9岁女孩BMI降低有关联,但在男孩中无此关联。在女孩中,位于产前BPA浓度最高的三分位数与BMI z分值降低(β=-0.47,95%CI:-0.87~-0.07)和体脂肪率降低(β=-4.36,95%CI:-8.37~-0.34)有关联;与位于最低三分位数组的女孩相比,超重/肥胖的风险下降[比值比(OR)=0.37,95%CI:0.16~0.91]。这些发现在青春期前期的女孩中最强。5岁时的尿BPA浓度与5岁或9岁时任何人体测量学参数没有相关性,在9岁时的BPA浓度与男孩和女孩9岁时的BMI、腰围、脂肪量、超重/肥胖呈正相关。[结论]本研究的发现与其他横断面研究相一致,9岁时尿BPA浓度较高与9岁时肥胖增加相关联。然而,母亲怀孕期间BPA浓度增加与他们的女儿9岁时BMI、体内脂肪和超重/肥胖降低有关联。 | Kim G.Harley Raul Aguilar Schall Jonathan Chevrier Kristin Tyler Helen Aguirre Asa Bradman Nina T.Holland Robert H.Lustig Antonia M.Calafat Brenda Eskenazi | 2013 | 环境与职业医学2013，30，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员