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| 1 | Vitamin D receptor gene Tru9I polymorphism and risk for incidental sporadic colorectal adenomas显示文摘瞄准:最近的实验室和流行病学的研究建议维生素D是为颜色的一个潜在的代理人表面的癌症预防。它的功能被维生素D受体(VDR ) 部分调停。这研究的目的是调查是否新奇 G (等位基因 "U")>A (等位基因 "u") 在 VDR intron 的多型性(Tru9I ) 8 区域为颜色与风险被联系在基于 colonoscopy 的盒子控制研究的表面的腺瘤。方法:为 391 个题目的一个总数的 Genotyping 通过 PCR 和限制碎片长度多型性被执行。结果:"U" 和 "u" 等位基因的频率分别地是 89.3% 和 10.7% 。"Uu" 和 "uu" 遗传型为腺瘤与减少的风险被联系(或, 0.71;95%CI, 0.40-1.25 ) 。反的协会为多重腺瘤是更显著的,更大的腺瘤有中等或更大的发育异常,或是无柄的:机会比率(ORs ) 是, 0.51 (95%CI, 0.21-1.24 ) , 0.37 (95%CI, 0.11-1.28 ) , 0.68 (95%CI, 0.33-1.41 ) ,并且 0.36 (95%CI, 0.13-0.97 ) 分别地。在连接 / 联合的分析,反的协会在有至少一 "u" 等位基因的那些之中并且也是更明显的更年轻(或, 0.60;95%CI, 0.26-1.37 ) ,女人们(或, 0.38;95%CI, 0.17-0.88 ) ,没吸烟(或, 0.39;95%CI, 0.13-1.23 ) ,或拿了 NSAID (或, 0.38;95%CI, 0.12-1.25 ) ,但是没有证据为和钙或维生素D吸入的相互作用存在。结论:我们的调查结果建议 VDR Tru9I 多型性可以为颜色与更低的风险被联系表面的腺瘤特别地在和各种各样的风险因素的相互作用,然而并非与钙或维生素D。 | You-Ling Gong Da-Wen Xie Zong-Lin Deng Roberd M Bostick Xi-Jiang Miao Jin-Hui Zhang Zhi-Hong Gong | 2005 | World Journal of Gastroenterology2005，11，31： | 1 |
| 2 | Colonoscopy procedural volume increases adenoma and polyp detection rates in gastroenterology trainees显示文摘AIM To investigate changes in polyp detection throughout fellowship training, and estimate colonoscopy volume required to achieve the adenoma detection rate(ADRs) and polyp detection rate(PDRs) of attending gastroenterologists.METHODS We reviewed colonoscopies from July 1, 2009 to June 30, 2014. Fellows' procedural logs were used to retrieve colonoscopy procedural volumes, and these were treated as the time variable. Findings from screening colonoscopies were used to calculate colonoscopy outcomes for each fellow for the prior 50 colonoscopies at each time point. ADR and PDR were plotted against colonoscopy procedural volumes to produce individual longitudinal graphs. Repeated measures linear mixed effects models were used to study the change of ADR and PDR with increasing procedural volume.RESULTS During the study period, 12 fellows completed full three years of training and were included in the analysis. The average ADR and PDR were, respectively, 31.5% and 41.9% for all fellows, and 28.9% and 38.2% for attendings alone. There was a statistically significant increase in ADR with increasing procedural volume(1.8%/100 colonoscopies, P = 0.002). Similarly, PDR increased 2.8%/100 colonoscopies(P = 0.0001), while there was no significant change in advanced ADR(0.04%/100 colonoscopies, P = 0.92). The ADR increase was limited to the right side of the colon, while the PDR increased in both the right and left colon. The adenoma per colon and polyp per colon also increased throughout training. Fellows reached the attendings' ADR and PDR after 265 and 292 colonoscopies, respectively.CONCLUSION We found that the ADR and PDR increase with increasing colonoscopy volume throughout fellowship. Our findings support recent recommendations of ≥ 275 colonoscopies for colonoscopy credentialing. | Emad Qayed Ravi Vora Sara Levy Roberd M Bostick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，11： | 1 |
| 3 | Association of trainee participation with adenoma and polyp detection rates显示文摘AIM To investigate whether adenoma and polyp detection rates(ADR and PDR, respectively) in screening colonoscopies performed in the presence of fellows differ from those performed by attending physicians alone. METHODS We performed a retrospective review of all patients who underwent a screening colonoscopy at Grady Memorial Hospital between July 1, 2009 and June 30, 2015. Patients with a history of colon polyps or cancer and those with poor colon preparation or failed cecal intubation were excluded from the analysis. Associations of fellowship training level with the ADR and PDR relative to attendings alone were assessed using unconditional multivariable logistic regression. Models were adjusted for sex, age, race, and colon preparationquality. RESULTS A total of 7503 colonoscopies met the inclusion criteria and were included in the analysis. The mean age of the study patients was 58.2 years; 63.1% were women and 88.2% were African American. The ADR was higher in the fellow participation group overall compared to that in the attending group: 34.5% vs 30.7%(P = 0.001), and for third year fellows it was 35.4% vs 30.7%(a OR = 1.23, 95%CI: 1.09-1.39). The higher ADR in the fellow participation group was evident for both the right and left side of the colon. For the PDR the corresponding figures were 44.5% vs 40.1%(P = 0.0003) and 45.7% vs 40.1%(a OR = 1.25, 95%CI: 1.12-1.41). The ADR and PDR increased with increasing fellow training level(P for trend < 0.05).CONCLUSION There is a stepwise increase in ADR and PDR across the years of gastroenterology training. Fellow participation is associated with higher adenoma and polyp detection. | Emad Qayed Lauren Shea Stephan Goebel Roberd M Bostick | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，5： | 0 |
| 4 | Novel genetic variations of the p53R2 gene in patients with colorectal adenoma and controls显示文摘AIM: p53-Inducible ribonucleotide reductase small subunit 2 (p53R2) encodes a 351-amino-acid peptide, which catalyzes conversion of ribonucleoside diphosphates to the corresponding deoxyribonucleotides required for DNA replication and repair. A recent study reported that a point mutation (G/T) in the p53 binding sequence in a colon cancer cell line completely impaired p53R2 protein activity.METHODS: We screened the p53R2 gene coding regions and a regulatory region which contains a p53 binding sequence in 100 patients with colorectal adenoma and 100 control subjects using PCR, cold SSCP, and direct DNA sequencing.RESULTS: Although we did not identify genetic variation in all nine exons, four regulatory-region variants were found,of which three were single nucleotide polymorphisms (SNPs) (nt 1 789 C/G, nt 1 928 A/G, 1 933 T/C), and one was 20 bp insertion which replaced a ATTTT between nt 1 831 and 1 835. Additionally, we determined the frequency of these p53R2 variants in a recently concluded case-control study of incident sporadic colorectal adenomas (163 cases and 210 controls).CONCLUSION: Although more detailed functional characterizations of these polymorphisms remain to be undertaken, these polymorphic sites may be useful for identifying alleles associated with mis-splicing, additional transcript factors and, more generally, in cancer-susceptibility association studies. | Zong-Lin Deng Da-Wen Xie Roberd M Bostick Xi-Jiang Miao You-Ling Gong Jin-Hui Zhang Michael J Wargovich | 2005 | World Journal of Gastroenterology2005，11，33： | 0 |
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