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| 1 | Genetic associations with adverse events from anti-tumor necrosis factor therapy in inflammatory bowel disease patients显示文摘AIM To study the type and frequency of adverse events associated with anti-tumor necrosis factor(TNF)therapy and evaluate for any serologic and genetic associations.METHODS This study was a retrospective review of patients attending the inflammatory bowel disease(IBD) centers at Cedars-Sinai IBD Center from 2005-2016. Adverse events were identified via chart review. IBD serologies were measured by ELISA. DNA samples were genotyped at Cedars-Sinai using Illumina Infinium Immunochipv1 array per manufacturer's protocol. SNPs underwent methodological review and were evaluated using several SNP statistic parameters to ensure optimal allele-calling. Standard and rigorous QC criteria were applied to the genetic data, which was generated using immunochip. Genetic association was assessed by logistic regression after correcting for population structure.RESULTS Altogether we identified 1258 IBD subjects exposed to anti-TNF agents in whom Immunochip data were available. 269/1258 patients(21%) were found to have adverse events to an anti-TNF-α agent that required the therapy to be discontinued. 25% of women compared to 17% of men experienced an adverse event. All adverse events resolved after discontinuing the antiTNF agent. In total: n = 66(5%) infusion reactions; n = 49(4%) allergic/serum sickness reactions; n = 19(1.5%) lupus-like reactions, n = 52(4%) rash, n = 18(1.4%) infections. In Crohn's disease, Ig A ASCA(P = 0.04) and Ig G-ASCA(P = 0.02) levels were also lower in patients with any adverse events, and anti-I2 level in ulcerative colitis was significantly associated with infusion reactions(P = 0.008). The logistic regression/human annotation and network analyses performed on the Immunochip data implicated the following five signaling pathways: JAK-STAT(Janus Kinase-signal transducer and activator of transcription), measles, IBD, cytokine-cytokine receptor interaction, and toxoplasmosis for any adverse event. CONCLUSION Our study shows 1 in 5 IBD patients experience an adverse event to anti-TNF therapy with novel serologic, genetic, and pathways associations. | Daniel Lew Soon Man Yoon Xiaofei Yan Lori Robbins Talin Haritunians Zhenqiu Liu Dalin Li Dermot PB McGovern | 2017 | World Journal of Gastroenterology2017，23，40： | 4 |
| 2 | Strategies for cutaneous gene therapy 显示文摘 | Robbins PB Khavari PA | 2000 | Current Problems In Dermatology-US2000，12，4： | 1 |
| 3 | Effects of the eate- chol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy eontols显示文摘 | Barnett JH Jones PB Robbins TW | 2007 | Mol Psychiatry2007，12，5： | 1 |
| 4 | Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells 显示文摘 | Robbins PB Skelton DC Yu XJ | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 5 | In vivo restoration of laminin 5 beta 3 expression and function in junctional epidermolysis bullosa显示文摘 | Robbins PB Lin Q Goodnough JB | 2001 | Proc Natl Acad Sci2001，98，： | 1 |
| 6 | Use of human tissue to assess the oncogenic activity of melanoma-associated mutations显示文摘 | Chudnovsky Y Adams AE Robbins PB | 2005 | Nat Genet2005，37，： | 1 |
| 7 | Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells 显示文摘 | Robbins PB Skelton DC Yu XJ | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 8 | Use of human tissue to assess the oncogenic activity of melanoma-associated mutations 显示文摘 | Chudnovsky Y Adams AE Robbins PB | 2005 | Nat Genet2005，37，7： | 1 |
| 9 | Prevalence and severity of mi-tral regurgitation in chronic systolic heart failure 显示文摘 | Robbins JD Maniar PB Cotts W | 2003 | Am J Cardiol2003，91，3： | 1 |
| 10 | Consistent, persistent expression from modified retroviral vectors in murine hematopoietic stem cells显示文摘 | Robbins PB Skelton DC Yu X J | 1998 | Proc Natl Acad Sci USA1998，95，10： | 1 |
| 11 | Sustainable systemic delivery via a single injection of lentivirus into human skin tissue显示文摘 | Baek SC Lin Q Robbins PB | 2001 | Hum Gene Ther2001，12，12： | 1 |
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