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| 1 | Epithelial toll-like receptor 9 signaling in colorectal inflammation and cancer: Clinico-pathogenic aspects显示文摘Toll-like receptors (TLRs) recognize specific motifs which are frequently present in bacteria, fungi, prokaryotes and viruses. Amongst TLRs, TLR9 can be activated by such bacterial or viral DNA fragments, immunoglobulin-DNA complexes or synthetic oligonucleotides, which all contain unmethylated cytosineguanine nucleotide sequences (CpGs). Emerging data indicate that TLR9 signaling has a role in, and may influence, colorectal carcinogenesis and colonic inflammation. CpGs are classified into three groups according to their influence on both the antigen-specific humoraland cellular immunity, and the production of type 1 interferons and proinflammatory cytokines. TLR9 activation via CpGs may serve as a new therapeutic target for several cancerous and various inflammatory conditions. Due to its probable anti-cancer effects, the application possibilities of TLR9-signaling modulation may be extremely diverse even in colorectal tumors. In this review we aimed to summarize the current knowledge about TLR-signaling in the pathogenesis and therapy of inflammatory bowel diseases and colorectal cancer. Due to the species-specific differences in TLR9 expression, however, one must be careful in translating the animal model data into the human system, because of the differences between CpG-oligodeoxynucleotide-responsive cells. TLR9 agonist DNA-based immunomodulatory sequences could also represent a promising therapeutic alternative in systemic inflammatory conditions and chronic colonic inflammations as their side effects are not significant. | István Fri Ferenc Sipos Tiana M Germann Alexandra Kalmár Zsolt Tulassay Béla Molnár Gyrgyi Mzes | 2013 | World Journal of Gastroenterology2013，19，26： | 14 |
| 2 | Contribution of TLR signaling to the pathogenesis of colitisassociated cancer in inflammatory bowel disease显示文摘In the intestine a balance between proinflammatory and repair signals of the immune system is essential for the maintenance of intestinal homeostasis. The innate immunity ensures a primary host response to microbial invasion, which induces an inflammatory process to localize the infection and prevent systemic dissemination of pathogens. The key elements of this process are the germline encoded pattern recognition receptors inclu-ding Toll-like receptors(TLRs). If pathogens cannot be eliminated, they may elicit chronic inflammation, which may be partly mediated via TLRs. Additionally, chronic inflammation has long been suggested to trigger tissue tumorous transformation. Inflammation, the seventh hallmark of cancer, may affect all phases of tumor development, and evade the immune system. Inflammation acts as a cellular stressor and may trigger DNA damage or genetic instability. Furthermore, chronic inflammation can provoke genetic mutations and epigenetic mechanisms that promote malignant cell transformation. Colorectal cancers in inflammatory bowel disease patients are considered typical examples of inflammation-related cancers. Although data regarding the role of TLRs in the pathomechanism of cancer-as-sociated colitis are rather conflicting, functionally these molecules can be classified as 'largely antitumorigenic' and 'largely pro-tumorigenic' with the caveat that the underlying signaling pathways are mainly context(i.e., organ-, tissue-, cell-) and ligand-dependent. | Ferenc Sipos István Fri Miklós Constantinovits Zsolt Tulassay Gyrgyi Mzes | 2014 | World Journal of Gastroenterology2014，20，36： | 9 |
| 3 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 4 | Relevance of α-defensins(HNP1-3) and defensin β-1 in diabetes显示文摘AIM: To investigate the genetic background of human defensin expression in type 1 and 2 diabetes.METHODS: Associations between DEFA1/DEFA3 gene copy number polymorphism and diabetes as well as between the promoter polymorphisms of DEFB1 and diabetes were studied. The copy number variation of the DEFA1/DEFA3 genes was determined in 257 diabetic patients(117 patients with type 1 and 140 with type 2 diabetes). The control group consisted of 221 age- and gender-matched healthy blood donors. The cumulative copy numbers of the DEFA1/DEFA3 genes were detected by using quantitative PCR analysis. To evaluate the HNP 1-3(human neutrophil peptide 1-3 or α-defensin) levels in the circulation, plasma HNP 1-3 concentrations were measured by ELISA. The expression of DEFA1/A3 in peripheral leukocytes of the diabetic patients was measured by quantitative RT PCR analysis. Three SNPs of the human DEFB1(human defensin β-1) gene: DEFB1 G-20A(rs11362), DEFB1 C-44G(rs1800972) and DEFB1 G-52A(rs1799946) were genotyped by Custom TaqMan? Real Time PCR assay.RESULTS: Significant differences were observed in HNP1-3 levels between the healthy subjects and both groups of diabetic patients. The mean ± SE was 28.78 ± 4.2 ng/mL in type 1 diabetes, and 29.82 ± 5.36 ng/mL in type 2 diabetes, vs 11.94 ± 2.96 ng/mL in controls; P < 0.01 respectively. There was no significant difference between patients with type 1 and type 2 diabetes in the high plasma concentrations of HNP1-3. The highest concentrations of α-defensin were found in diabetic patients with nephropathy(49.4 ± 4.8 ng/mL), neuropathy(38.7 ± 4.8 ng/mL) or cardiovascular complications(45.6 ± 1.45 ng/L). There was no significant difference in the cumulative copy numbers of DEFA1/DEFA3 genes between controls and patients, or between patients with the two types of diabetes. Comparisons of HNP 1-3 plasma level and DEFA1/A3 copy number of the same patient did not reveal significant relationship between defensin-α levels and the gene copy numbers(r2 = 0.01). Similarly, no positive correlation was observed between the copy numbers and the mRNA expression levels of DEFA1/A3. Regarding the C-44G polymorphism of DEFB1, the GG 'protective' genotype was much less frequent(1%-2%) among both groups of patients than among controls(9%).CONCLUSION: Elevated HNP1-3 levels in diabetes are independent of DEFA1/DEFA3 copy numbers, but GG genotype of C-44G SNP in DEFB1 gene may result in decreased defensin β-1 production. | Balázs Csaba Németh Tamás Várkonyi Ferenc Somogyvári Csaba Lengyel Katalin Fehértemplomi Szabolcs Nyiraty Péter Kempler Yvette Mándi | 2014 | World Journal of Gastroenterology2014，20，27： | 4 |
| 5 | A highly concentrated vanadium protic ionic liquid electrolyte for the vanadium redox flow battery显示文摘A protic ionic liquid is designed and implemented for the first time as a solvent for a high energy density vanadium redox flow battery.Despite being less conductive than standa rd aqueous electrolytes,it is thermally stable on a 100 ℃ temperature window,chemically stable for at least 60 days,equally viscous and dense with typical aqueous solvents and most importantly able to solubilize to 6 mol L^(-1) vanadium sulfate,thus increasing the VRFB energy density by a factor of 2.5.Electrochemical measurements revealed quasi-reversible redox transitions for both catholyte and anolyte at 25 ℃ while a proof-of-concept redox flow cell with the proposed electrolyte was tested for a total of 150 cycles at 25 ℃,showing an open circuit potential of 1.39 V and energy and coulombic efficiencies of 65% and 93%,respectively.What’s more,the battery can be equally cycled at 45℃ showing good thermal stability.This study underlines a new route to improve the energy-to-volume ratio of energy storage system. | Georgios Nikiforidis Amal Belhcen Mérièm Anouti | 2021 | Journal of Energy Chemistry2021，30，6： | 4 |
| 6 | Influence of Ultrasonic Treatment on Various Membrane Materials: A Review显示文摘 | M. Kallioinen M. M?ntt?ri | 2011 | Separation Science and Technology2011，，9： | 2 |
| 7 | Diffusion tensor MRI of the human kidney显示文摘 | Ries M Jones RA Basseau F | 2001 | J Magn Reson Imaging2001，14，1： | 1 |
| 8 | A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies:TTF-1 is expressed in both round and surface cells,suggesting an origin from primitive respiratory epithelium显示文摘 | Devouassoux-shisheboran M Hayashi T Linnoila RI | 2000 | Am J Surg Pathol2000，24，7： | 1 |
| 9 | Cancer surveillance series: recent trends in childhood cancer incidence and mortality in the United States 显示文摘 | Linet S Ries L A Smith M A | 1999 | J Nad Cancer Inst1999，91，12： | 1 |
| 10 | Enzyme-replacement therapy with agalsidase alfa inchildren with Fabry disease显示文摘 | Ries M Clarke JT Whybra C Timmons M Robinson C Schlaggal BL | 2006 | Pediatrics2006，118，3： | 1 |
| 11 | A clinicopathologic study of 100 cases of puhnonary sclerosing bemangioma with immunohistochemical studies: TTF - 1 is expressed in both round and surface cells, Suggesting an orgin from primitive respiratory epithelium 显示文摘 | Devouassou - Shisheoran M Hayashi T Linnoila RI | 2000 | Am J Surg Pathol2000，24，： | 1 |
| 12 | Thickness of reti-nal nerve fiber layer correlates with disease duration in parallelwith corticospinal tract dysfunction in untreated multiple scle-rosis显示文摘 | Spain RI Maltenfort M Sergott RC | 2009 | J Rehabil Res Dev2009，46，5： | 1 |
| 13 | A pilot study to describe antidepressant presciptions dispensed to yetemns after 显示文摘 | Ried L D Tueth M J Jin H | 2006 | Res Social Admpham2006，2，1： | 1 |
| 14 | MMP-2,MT1-MMP,and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells:differential regulation by inflammatory cytokines显示文摘 | Ries C EgeaV Karow M etal | 2007 | Blood2007，109，9： | 1 |
| 15 | A clinicopathologic study of 100 cases of pulmonary sclerosing hemangioma with immunohistochemical studies:TTF-1 is expressed in both round and surface cells,suggesting an origin from primitive respiratory epithelium显示文摘 | Hayashi T Linnoila RI | 2000 | Am J Surg Pathol2000，24，7： | 1 |
| 16 | Evaluation of nanofil-tration membranes for filtration of paper mill total effluent显示文摘 | M!ntt!ri M Nuortila-jokinen J Nystr!m M | | FiltrSep0，34，3： | 1 |
| 17 | T2 relaxation time measurements in osteoarthritis 显示文摘 | David-Vaudey E Ghosh S Ries M | 2004 | Magn Reson Ima- ging2004，22，5： | 1 |
| 18 | Vaccine potential for inactivated shigellae 显示文摘 | Osorio M Bray MD Walker RI | 2007 | Vaccine2007，25，9： | 1 |
| 19 | The basic helix-loop-helix transcription factors myogenin and Id2 mediate specific induction of caveolin-3 gene expression during embryonic development 显示文摘 | Biederer CH Ries SJ Moser M | 2000 | J Biol Chem2000，275，26： | 1 |
| 20 | Estimation of biomass in aneotropical forest of French Guiana:spatial and temporal variability显示文摘 | Chave J Riéra B Dubois M A | 2001 | Journal ofTropical Ecology2001，17，： | 1 |
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