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| 1 | S100B protein in tissue development,repair and regeneration显示文摘The Ca 2+-binding protein of the EF-hand type,S100B,exerts both intracellular and extracellular regulatory activities.As an intracellular regulator,S100B is involved in the regulation of energy metabolism,transcription,protein phosphorylation,cell proliferation,survival,differentiation and motility,and Ca 2+ homeostasis,by interacting with a wide array of proteins(i.e.,enzymes,enzyme substrates,cytoskeletal subunits,scaffold/adaptor proteins,transcription factors,ubiquitin E3 ligases,ion channels) in a restricted number of cell types.As an extracellular signal,S100B engages the pattern recognition receptor,receptor for advanced glycation end-products(RAGE),on immune cells as well as on neuronal,astrocytic and microglial cells,vascular smooth muscle cells,skeletal myoblasts and cardiomyocytes.However,RAGE may not be the sole receptor activated by S100B,the protein being able to enhance bFGF-FGFR1 signaling by interacting with FGFR1-bound bFGF in particular cell types.Moreover,extracellular effects of S100B vary depending on its local concentration.Increasing evidence suggests that at the concentration found in extracellular fluids in normal physiological conditions and locally upon acute tissue injury,which is up to a few nM levels,S100B exerts trophic effects in the central and peripheral nervous system and in skeletal muscle tissue thus participating in tissue homeostasis.The present commentary summarizes results implicating intracellular and extracellular S100B in tissue development,repair and regeneration. | Guglielmo Sorci Francesca Riuzzi Cataldo Arcuri Claudia Tubaro Roberta Bianchi Ileana Giambanco Rosario Donato | 2013 | World Journal of Biological Chemistry2013，4，1： | 14 |
| 2 | S100B's double life:intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochirn Biophys Acta2009，1793，6： | 1 |
| 3 | S100B~ s double life : in- tracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acta2009，1793，10： | 1 |
| 4 | S1006s double life:intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acts2009，1793，6： | 1 |
| 5 | RAGE expression in rhabdomyo- sarcoma cells results in myogenic differentiation and reduced pro- liferation, migration, invasiveness,and tumor growth显示文摘 | Riuzzi F Sorci Q Donato R | 2007 | Am J Pathol2007，171，3： | 1 |
| 6 | S100Bs' double life: intracellu -lar regulator and extracellular signal 显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim BiophysActa2009，1793，6： | 1 |
| 7 | Functional inactivation of RAGE in L6 myoblasts results in tumor formation in vivo显示文摘 | Riuzzi F Sorci G Donato R | 2005 | J Biol Chem2005，281，12： | 1 |
| 8 | S100B’s double life:intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 9 | S100B's double life: intra- cellular regulator and extracellular signal 显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 10 | RAGE in tissue homeostasis,repair and regeneration显示文摘 | Sorci G Riuzzi F Giambanco I | 2013 | Biochim Biophys Acta2013，1833，1： | 1 |
| 11 | S100B' s double life:Intraeel-lular regadator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Bioehim Biophys Ac-ta2009，1793，6： | 1 |
| 12 | SlOOb Protein, a Damage-As-sociated Molecular Pattern Protein in the Brain and Heart,and Be-yond显示文摘 | Sorci G Bianchi R Riuzzi F et cd | 2010 | Cardiovasc Psychiatry Neurol2010，2010，1： | 1 |
| 13 | SlOOB's doublelife : Intracellular regulator and extracellular signal 显示文摘 | DONATO R SORCI G RIUZZI F | 2009 | Biochim Biophys Acta2009，1793，11： | 1 |
| 14 | Amphoterin stimula- tes myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100B via RAGE bin- ding显示文摘 | Sorci G Riuzzi F Arcuri C | 2004 | Mol Cell Biol2004，24，11： | 1 |
| 15 | S100B's double life: Intracellular regulator and extracellular signal 显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochimica Biophysica Acta2009，1793，5： | 1 |
| 16 | S100B's double life:Intracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | | 0，，06： | 1 |
| 17 | Amphoterin stimulates myogenesis and counteracts the antimyogenic factors basic fibroblast growth factor and S100Bvia RAGE binding显示文摘 | Sorci G Riuzzi F Arcuri C | 2004 | Mol Cell Biol2004，24，11： | 1 |
| 18 | The danger signal S100B integrates pathogen-and danger-sensing pathways to restrain inflammation显示文摘 | Sorci G Giovannini G Riuzzi F | 2011 | PLoS Pathog2011，7，10： | 1 |
| 19 | S100B's double life: in tracellular regulator and extracellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochim Biophys Acta2009，1793，6： | 1 |
| 20 | S100B's double life: in-tracellular regulator and extraeellular signal显示文摘 | Donato R Sorci G Riuzzi F | 2009 | Biochirn Biophys Acta2009，1793，6： | 1 |
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