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| 1 | Pharmacologic inducers of the uric acid exporter ABCG2 as potential drugs for treatment of gouty arthritis显示文摘Uric acid is the end product of purine catabolism and its plasma levels are maintained below its maximum solubility in water(6–7 mg/dl).The plasma levels are tightly regulated as the balance between the rate of production and the rate of excretion,the latter occurring in urine(kidney),bile(liver)and feces(intestinal tract).Reabsorption in kidney is also an important component of this process.Both excretion and reabsorption are mediated by specific transporters.Disruption of the balance between production and excretion leads to hyperuricemia,which increases the risk of uric acid crystallization as monosodium urate with subsequent deposition of the crystals in joints causing gouty arthritis.Loss-of-function mutations in the transporters that mediate uric acid excretion are associated with gout.The ATP-Binding Cassette exporter ABCG2 is important in uric acid excretion at all three sites:kidney(urine),liver(bile),and intestine(feces).Mutations in this transporter cause gout and these mutations occur at significant prevalence in general population.However,mutations that are most prevalent result only in partial loss of transport function.Therefore,if the expression of these partially defective transporters could be induced,the increased number of the transporter molecules would compensate for the mutation-associated decrease in transport function and hence increase uric acid excretion.As such,pharmacologic agents with ability to induce the expression of ABCG2 represent potentially a novel class of drugs for treatment of gouty arthritis. | Bojana Ristic Mohd Omar Faruk Sikder Yangzom D.Bhutia Vadivel Ganapathy | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，2： | 13 |
| 2 | Effect of sedative agent selection on morbidity, mortality and length of stay in patients with increase in intracranial pressure显示文摘BACKGROUND: To identify the effects of sedative agent selection on morbidity, mortality, and length of stay in patients with suspected increase in intracranial pressure. Recent trends and developments have resulted in changes to medications that were previously utilized as pharmacological adjuncts in the sedation and intubation of patients with suspected increases in intracranial pressure. Medications that were previously considered contraindicated are now being used with increasing regularity without demonstrated safety and effectiveness. The primary objective of this study is to evaluate and compare the use of Ketamine as an induction agent for patients with increased intracranial pressure. The secondary objective was to evaluate and compare the use of Etomidate, Midazolam, and Ketamine in patients with increased intracranial pressure. METHODS: We conducted a retrospective chart review of patients transported to our facility with evidence of intracranial hypertension that were intubated before trauma center arrival. Patients were identifi ed during a 22-month period from January 2014 to October 2015. Goals were to evaluate the impact of sedative agent selection on morbidity, mortality, and length of stay.RESULTS: During the review 148 patients were identifi ed as meeting inclusion criteria, 52 were excluded due to incomplete data. Of those the patients primarily received; Etomidate, Ketamine, and Midazolam. Patients in the Ketamine group were found to have a lower mortality rate after injury stratifi cation. CONCLUSION: Patients with intracranial hypertension should not be excluded from receiving Ketamine during intubation out of concern for worsening outcomes. | Brian G.Cornelius Elizabeth Webb Angela Cornelius Kenneth W.G.Smith Srdan Ristic Jay Jain Urska Cvek Marjan Trutschl | 2018 | World Journal of Emergency Medicine2018，9，4： | 4 |
| 3 | Factors which influence postoperative mortality after hip fracture 显示文摘 | Ristic B Risti6 DI Milici6 B | 2006 | Vojnosanit Preg2006，63，1： | 1 |
| 4 | Cramer-Rao Bound for Nonlinear Filtering With Pd<1 and Its Application to Target Tracking 显示文摘 | Farina A Ristic B Timmoneri L | 2002 | IEEE Transactions on Signal Processing2002，，50： | 1 |
| 5 | Tracking a manoeuvring target using angle-only measurements:algorithms and performance显示文摘 | Ristic B and Arulampalam M S | 2003 | Signal Processing2003，83，： | 1 |
| 6 | Comments on the Cramer- Rao Lower Bounds for Signals With Constant Ampli- tude And Polynomial Phase 显示文摘 | RISTIC B BOASHASH B | 1998 | IEEE Trans on Signal Processing1998，46，6： | 1 |
| 7 | Tracking a Ballistic Target: Comparison of Several Nonlinear Filters显示文摘 | FARINA A RISTIC B BENVENUTI D | 2002 | IEEE Trans on Aerospace and Electronic Systems2002，38，3： | 1 |
| 8 | CAD- based measurement path planning for free - form shapes using contact probes显示文摘 | Ainsworth I Ristic M Brujic D | 2000 | International Journal of Advanced Manufacturing Technology2000，16，1： | 1 |
| 9 | Maximum likelihood registration for multiple dissimilar radars显示文摘 | OKELLO N N RISTIC B | 2003 | IEEE Transactions on Aerospace and Electronic Systems2003，39，3： | 1 |
| 10 | Exclusion of sunlightfrom Shiraz grapes alters wine colour,tannin and sensory proper-ties 显示文摘 | Ristic R Downey M O Iland P G | 2007 | Aust J Grape Wine Res2007，13，1： | 1 |
| 11 | Tracking a ballistic tar-get: comparison of severalnonlinear filters 显示文摘 | Frina A Ristic B Benvenuti D | 2002 | IEEETransactions on Aerospace and Electronic Systems2002，38，3： | 1 |
| 12 | Puhnonary function parameters as prognostic factors in advanced non-small cell lung cancer显示文摘 | Rancic M Ristic L Rancic S | 2014 | Med Glas(Zenica)2014，11，1： | 1 |
| 13 | Ac- tivation of ERK, AKT and JNK signalling pathways in human schwannomas in situ显示文摘 | HILTON D A RISTIC N HANEMANN C O | 2009 | Histopathology2009，55，： | 1 |
| 14 | high TC superconducting powders synthesis from aerosol显示文摘 | Mancic L Milosevic O Ristic M M | 2001 | Journal of the European Ceramic Society2001，21，： | 1 |
| 15 | A particle filter for joint detection and tracking of color objects 显示文摘 | Czyz J Ristic B Macq B | 2006 | Image and Vision Computing(S0262-8856)2006，25，8： | 1 |
| 16 | Level of PAHs in the soils of Belgrade and its environs显示文摘 | Ristic M Jovanovic A | 2007 | Environ Monit Assess2007，125，13： | 1 |
| 17 | Immobilization of dextransucrase on regenerated benzoyl cellulose carriers 显示文摘 | Petroijeviz Z Ristic S Pesic D | 2007 | Enzyme and Microbial Technology2007，，40： | 1 |
| 18 | The two-dimension static charge distribution on SAW interdigital transducer显示文摘 | Ristic V M | 1979 | IEEE Transactions on Sonics and Ultrasonics1979，26，4： | 1 |
| 19 | Bayesian multi-object filtering with amplitude feature likelihood for unknown object SNR 显示文摘 | Clark D E Ristic B Vo Ba-Ngu | 2010 | IEEE Transactions on Signal Processing2010，58，1： | 1 |
| 20 | A metric for performance evaluation of multi-target tracking algorithms显示文摘 | RISTIC B VO B N CLARK D | 2011 | IEEE Transactions on Signal Processing2011，59，7： | 1 |
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