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| 1 | Inflammatory bowel disease: Traditional knowledge holds the seeds for the future显示文摘Despite the level of sophistication they have reached nowadays, the available tools for treatment of inflammatory bowel disease(IBD) can at best chronicize the disease but not cure it. Chances to make leap forward from this hold-back may include designs to reach personalized treatment strategies taking advantage of modern genome associated studies, and shift resources towards unfolding inciting pathogenetic steps rather than continuing to develop drugs that address down-stream phenomena. We have arbitrarily chosen to scrutinize a few projects that may make their way in 2015 and mark the history of IBD research. The list includes: the role of appendix as a regulating factor in pathogenesis of ulcerative colitis/proctitis; the reappraisal of(auto)immune phenomena in the era of microbiome; projects to treat IBD by stem cell infusion; recognition of the crucial pathogenetic role of gut microbiome, and attempts to modify it to treat enteric diseases, from clostridium difficile infection to IBD. | Giovanni C Actis Rinaldo Pellicano Floriano Rosina | 2015 | World Journal of Gastrointestinal Pharmacology and Therapeutics2015，6，2： | 6 |
| 2 | Inflammatory bowel diseases: Current problems and future tasks显示文摘Current knowledge on inflammatory bowel disease(IBD)is mainly endorsed by controlled trials and epidemiologic studies. Yet,we seldom look at the messages from real-world practice. Among a patient population followed since2008,we looked at an unselected sample of 64 IBD patients [26 Crohn's disease(CD) and 38 ulcerative colitis(UC)] who had been seen as out-patients in the last year.Inducing remission,mesalamines(86% for UC/69% for CD/33%-16% as MMX formulation) prevailed as prescrip-tions; steroids(55%/19% for UC/CD) ranked second.Prescription of third-party drugs(antibiotics,NSAIDs,biologics) and adherence,were issues in the maintenance.34% of CD,and 23% of UC patients showed accompany-ing immunologic diseases: CD-associated familiar psoriasis(4:9) ranked first. Main Message. The association between IBD(CD mainly) and psoriasis,now found in our practice,matches current basic science gathering IBD together with psoriasis(and perhaps chronic respiratory disease) under the comprehensive term 'barrier organ disease' wherein an epithelial surface with sensor system srules contacts between outer antigens and a reactive underneath tissue,with the balance between inflammation and quiescence kept at any time by mucosal permeability.IBD is thus viewed as a polyfactorial/polygenic/syndromic disorder,embedded into a galaxy of immune conditions offering multiple points of attack. This mindset of splitting the IBDs into pathogenic categories may allow overcoming the uniformly targeting of a single cytokine by biological drugs,in favor of demarcating the boundaries between different disease-subtype-specific indications,and paving the way to future personalized strategies. | Giovanni C Actis Floriano Rosina Rinaldo Pellicano | 2014 | World Journal of Gastrointestinal Pharmacology and Therapeutics2014，5，3： | 3 |
| 3 | SK2 channel expression and function in cerebellar Purkinje cells显示文摘 | Hosy E Piochon C Teuling E Rinaldo L Hansel C | 2011 | J Physiol2011，589，14： | 1 |
| 4 | Primary treatment of the anterior vocal commissure squamous carcinoma 显示文摘 | BRADLEY P J RINALDO A SUAREZ C | 2006 | Eur Arch Otorhinolaryngal2006，263，10： | 1 |
| 5 | Prognostic value of HIV-1 RNA,CD4 cell count,and CD4 Cell count slope for progression to AIDS and death in untreated HIV-1infection显示文摘 | Mellors J W Margolick J B Phair J P Rinaldo C R Detels R Jacobson L P Mu noz A | 2007 | JAMA2007，297，21： | 1 |
| 6 | Paraneoplastic syndromes in patients with nasopharyngeal cancer显示文摘 | Toro C Rinaldo A Silver CE | 2009 | Auris Nasus Larynx2009，36，5： | 1 |
| 7 | Conceptual De- sign of an AUV Equipped with a Three Degree of Free- dom Vectored Thruster显示文摘 | Emanuele Cavallo Rinaldo C Michelini | 2004 | Journal of Intelligent b- Robotic Systems2004，39，： | 1 |
| 8 | An innovative modelization of loss mechanism in silicon integrated inductors显示文摘 | Paolo A Rinaldo C | 1999 | IEEE Trans1999，46，12： | 1 |
| 9 | Current treat- ment options for recurrent nasopharyngeal cancer 显示文摘 | SUAREZ C RODRIGO J P RINALDO A | 2010 | Eur Arch Otorhinolaryngol2010，267，12： | 1 |
| 10 | OSAS treatment with oral appliance:assessment of our experience through the use of a new device显示文摘 | Gasparini G Azzuni C Rinaldo FM | 2013 | Eur Rev Med Pharmacol Sci2013，17，3： | 1 |
| 11 | Evaluation of antioxidant activity of some natural polyphenolic compounds using the Briggs-Rauscher reaetion method显示文摘 | RINALDO C CECILIA R MARIA C | 2002 | Agric Food Chem2002，50，： | 1 |
| 12 | Sexual transmission efficiency of hepatitis B virus and human immunodeficiency virus among homosexual men 显示文摘 | KINGSLEY L A RINALDO C R Jr LYTER D W | 1990 | JAMA1990，264，2： | 1 |
| 13 | Atom Transfer Radical Polymerisation of Styrene Controlled by Phosphine-containing Coordination Compounds of Mo( Ⅲ )/Mo( IV ) 显示文摘 | Francois S Jerome C Rinaldo P | 2002 | C R Chimie2002，5，： | 1 |
| 14 | The risk Of-Pneumocystis carinii pneumoniasmongmen ifected with human immunodeficiency virustupe显示文摘 | Phair J Munoz A Detels R Kaslow R Rinaldo C Saah A | 1990 | N Engl JMed1990，12，： | 1 |
| 15 | High Mobility Group A1 (HMGA1) proteins interact with p53 and inhibit its apoptotic activity显示文摘 | Pierantoni GM Rinaldo C Esposito F | | 0，，09： | 1 |
| 16 | Preoperative sonographic features of borderline ovarian tumors显示文摘 | Exacoustos C Romanini ME Rinaldo D | 2005 | Ultrasound Obstet Gynecol2005，25，： | 1 |
| 17 | Pa- rastomal recurrence:a therapeutic challenge显示文摘 | FERLITO A SILVER C E RINALDO A | 2002 | Acta Otolaryngol2002，122，： | 1 |
| 18 | Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis显示文摘 | DI STEFANO V RINALDO C SACCHI A | 2004 | Exp Cell Res2004，293，2： | 1 |
| 19 | Preoperative sonographie features of borderline ovarian tumors显示文摘 | Exacoustos C Romanini M E Rinaldo D | 2005 | Ultrasound Obstet Gyneeo12005，25，1： | 1 |
| 20 | Hamartoma of the larynx:a critical review of the literature显示文摘 | Rinaldo A Mannara GM Fisher C | 1998 | Ann Otol Rhinol Laryngol1998，107，3： | 1 |
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