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| 1 | Mechanisms of autophagy activation in endothelial cell and their targeting during normothermic machine liver perfusion显示文摘Ischaemia-reperfusion injury(IRI) is the leading cause of injury seen in the liver following transplantation. IRI also causes injury following liver surgery and haemodynamic shock. The first cells within the liver to be injured by IRI are the liver sinusoidal endothelial cells(LSEC). Recent evidence suggests that LSEC coordinate and regulates the livers response to a variety of injuries. It is becoming increasingly apparent that the cyto-protective cellular process of autophagy is a key regulator of IRI. In particular LSEC autophagy may be an essential gatekeeper to the development of IRI. The recent availability of liver perfusion devices has allowed for the therapeutic targeting of autophagy to reduce IRI. In particular normothermic machine liver perfusion(NMP-L) allow the delivery of pharmacological agents to donor livers whilst maintaining physiological temperature and hepatic flow rates. In this review we summarise the current understanding of endothelial autophagy and how this may be manipulated during NMP-L to reduce liver IRI. | Yuri L Boteon Richard Laing Hynek Mergental Gary M Reynolds Darius F Mirza Simon C Afford Ricky H Bhogal | 2017 | World Journal of Gastroenterology2017，23，48： | 4 |
| 2 | Autologous mesenchymal stem cells for the treatment of secondary progressive multiple sclerosis: an open-label phase 2a proof-of-concept study显示文摘 | Peter Connick Madhan Kolappan Charles Crawley Daniel J Webber Rickie Patani Andrew W Michell Ming-Qing Du Shi-Lu Luan Daniel R Altmann Alan J Thompson Alastair Compston Michael A Scott David H Miller Siddharthan Chandran | 2012 | Lancet Neurology2012，，2： | 2 |
| 3 | Impact of machine perfusion of the liver on post-transplant biliary complications: A systematic review显示文摘AIM To review the clinical impact of machine perfusion(MP) of the liver on biliary complications post-transplantation, particularly ischaemic-type biliary lesions(ITBL). METHODS This systematic review was performed in accordance with the Preferred Reporting Systematic Reviews and MetaAnalysis(PRISMA) protocol. The following databases were searched: PubMed, MEDLINE and Scopus. The keyword 'liver transplantation' was used in combination with the free term 'machine perfusion'. Clinical studies reporting results of transplantation of donor human livers following ex situ or in situ MP were analysed. Details relating to donor characteristics, recipients, technique of MP performed and post-operative biliary complications(ITBL, bile leak and anastomotic strictures) were critically analysed.RESULTS Fifteen articles were considered to fit the criteria for this review. Ex situ normothermic MP was used in 6 studies, ex situ hypothermic MP in 5 studies and the other 4 studies investigated in situ normothermic regional perfusion(NRP) and controlled oxygenated rewarming. MP techniques which have per se the potential to alleviate ischaemia-reperfusion injury: Such as hypothermic MP and NRP, have also reported lower rates of ITBL. Other biliary complications, such as biliary leak and anastomotic biliary strictures, are reported with similar incidences with all MP techniques. There is currently less clinical evidence available to support normothermic MP as a mitigator of biliary complications following liver transplantation. On the other hand, restoration of organ to full metabolism during normothermic MP allows assessment of hepatobiliary function before transplantation, although universally accepted criteria have yet to be validated.CONCLUSION MP of the liver has the potential to have a positive impact on post-transplant biliary complications, specifically ITBL, and expand extended criteria donor livers utilisation. | Yuri L Boteon Amanda PCS Boteon Joseph Attard Lorraine Wallace Ricky H Bhogal Simon C Afford | 2018 | World Journal of Transplantation2018，8，6： | 2 |
| 4 | N - terminal pro brain natriuretic peptide - guided management in patients with heart failure and preserved ejection fraction: findings from the Trial of Intensified versus standard medical therapy in elderly patients with congestive heart failure (TIME - CHF) 显示文摘 | MAEDER M T RICKENBACHER P RICKI H | 2013 | Eur J Heart Fail2013，15，10： | 1 |
| 5 | Relationship marketing in China:Guanxi,favoritism and adaptation 显示文摘 | Wong Y H Chan Ricky Yee-kwong | 1999 | Journal of Business Ethics1999，22，2： | 1 |
| 6 | Relationship marketing in China: Guanxi, favouritism and adaptation显示文摘 | Wong Y H and Chan Ricky Yee-kwong | 1999 | Journal of Business Ethics1999，22，2： | 1 |
| 7 | Haff disease after eating salmon显示文摘 | Langley Ricky L Bobbitt William H III | | 0，，11： | 1 |
| 8 | Pharmacodynamic and pharmacokinetic study of oral curcuma extract in patients with colorectal cancer显示文摘 | RICKY A S HEATHER R M KIRSTI A H | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 9 | Effects of build - up printed circuit board thickness on the solder joint reliability of a wafer level chip scale package ( WLCSP ) 显示文摘 | John H Lau S W Ricky Lee | 2002 | IEEE transactions on components and packaging technology2002，25，1： | 1 |
| 10 | The chemical and biological properties of methoxyfenozide,a new insecticidal ecdysteroid agonist显示文摘 | GLENN R C Tarlochan S D Ricky H | 2001 | Pest Management Science2001，57，： | 1 |
| 11 | Barrier performance of silane-clay nanocomposite coatings on concrete structure显示文摘 | RICKY S C ZHU H G MICHAEL M K | 2008 | Compersite Science and Technology2008，，68： | 1 |
| 12 | Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer 显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clin Cancer Res2001，7，7： | 1 |
| 13 | Genetic modification removes an immunodomiant allergen from soybean显示文摘 | Eliot M H P Ricki M H RudolfJ | 2003 | Plant Physiol2003，132，： | 1 |
| 14 | Pasteurella multocida produces a protein with homology to the P6 outer membrane protein of Haemophilus influenzae显示文摘 | RICKIE W K LORI M H JULIAN H | 1995 | Infect Immun1995，63，3： | 1 |
| 15 | Food allergy animal models显示文摘 | RICKI M H | 2002 | Ann N Y Acad Sci2002，964，： | 1 |
| 16 | A neonatal swine model for peanut allergy显示文摘 | RICKI M H GLENN T F J STEVE STANLEY | 2002 | J Allergy Clin Immunol2002，109，： | 1 |
| 17 | Com- mitment and vulnerability in B2B relationship selling in the Hong Kong institutional insurance service in- dustry显示文摘 | WongY H Chan Ricky Y K Leung T K P | 2008 | Services Marketing2008，22，2： | 1 |
| 18 | Pharmacodynamie aud pharmacokinetic study of oral eureuma extract in patients with colorectal cancer 显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clinical Cancer Research2001，7，7： | 1 |
| 19 | Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer显示文摘 | Ricky A S Heather R M Kirsti A H | 2001 | Clin Cancer Rcs2001，7，7： | 1 |
| 20 | Evolutionary Multimodal Optimization Using the Principle of Locality 显示文摘 | WONG K C WU C H RICKY K P M | 2012 | Information Sciences2012，194，： | 1 |
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