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| 1 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 2 | Effects of far-off and close-up transition cow feeding on uterine health,postpartum anestrous interval,and reproductive outcomes in pasture-based dairy cows显示文摘Background:In seasonal,pasture-based,dairy production systems,cows must recover from calving and become pregnant within two to 3 months.To achieve this,the uterus must involute and ovulation must occur and continue at regular intervals.As these processes are affected by the cows’nutritional or metabolic status post-calving,the objective of this study was to evaluate the effect of cow feeding strategies on uterine health,the length of postpartum anestrous interval,and reproductive outcomes.The treatments consisted of two feeding strategies during late-lactation and early dry period(far-off period;starting 4-month pre-calving)and three close-up dry period feeding regimes(1-month pre-calving)in a 2×3 factorial arrangement.We randomly assigned 150 cows to one of two far-off treatments.During late lactation,the herds(n=75 cows per herd)were either control-fed(Controlfed)or over-fed(Overfed)to achieve a low or high body condition score(4-month pre-calving;BCS;~4.25 and^4.75;10-point scale)at cessation of lactation.Within each of these treatments,three feeding levels were applied during the close-up period(1-month pre-calving):~65%(Feed65),~90%(Feed90),or^120%(Feed120)of metabolizable energy(ME)intakes relative to pre-calving requirements.Results:Uterine health improved(i.e.polymorphonucleated(PMN)cells declined)with increased feeding during the close-up period for cows in the Overfed group.The reverse was evident for the Controlfed group with the greatest PMN at the highest intakes during the close-up period.The postpartum anoestrous interval(PPAI)was shorter in cows from the Overfed group when moderately fed(Feed90)during the close-up period;in comparison,the PPAI was shorter in the Controlfed group,when those cows were overfed in the close-up period(Feed120).The cows in the Overfed treatment had greater conception and pregnancy rates if cows had moderate dry matter intakes(Feed90)during the close-up period;these reproductive variables were less under excessive feed intakes(Feed120);yet,close-up dry matter intake had little effect on conception and pregnancy rates for the Controlfed group.Conclusions:The far-off feeding strategies increased early reproductive outcomes at 3 weeks of mating.Additionally,the interaction between far-off and close-up feeding strategies resulted in high six-week pregnancy rate with a slight restriction during the close-up period but only in the far-off Overfed group.Thus,our hypothesis is supported under these conditions. | S.Meier J.K.Kay B.Kuhn-Sherlock A.Heiser M.D.Mitchell M.A.Crookenden M.Vailati Riboni J.J.Loor J.R.Roche | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 3 |
| 3 | Primary vulvar Ewing’s sarcoma/primitive neuroectodermal tumor in a post-menopausal woman: a case report显示文摘 | Boldorini R Riboni F Cristina S | 2010 | Pathol Res Pract2010，206，7： | 1 |
| 4 | Phosphorylated insulin-like growth factor binding protein-1 in cervical secretions and sonographic cervical length in the prediction of spontaneous preterm delivery显示文摘 | Paternoster D Riboni F Vitulo A | 2009 | Ultrasound Obstet Gynecol2009，34，4： | 1 |
| 5 | New mini- resectoscope: analysis of preliminary quality results in outpatient hysteroscopic polypectomy 显示文摘 | Dealberti D Riboni F Prigione S | 2013 | Arch Gynecol Obstet2013，288，2： | 1 |
| 6 | WO3-TiO 2vs TiO 2photocatalysts:effect of the W precursor and amount on the photocatalytic activity of mixed oxides显示文摘 | Riboni F Bettini L G Bahnemann D W | 2013 | Catal Today2013，209，： | 1 |
| 7 | Primary vulvar Ewing's sarcoma/primitive neuroectodermal tumor in a post-menopausal woman:a case report显示文摘 | Boldorini R Riboni F Cristina S | | 0，，07： | 1 |
| 8 | COSAR:Hybrid reasoning for context-aware activity recognition 显示文摘 | Riboni D Bettini C | 2011 | Personal and Ubiquitous Com-puting2011，15，3： | 1 |
| 9 | Ceramide levels are inversely associated with malignant progression of human glial tumors 显示文摘 | Riboni L Campanella R Bassi R Villani R Gaini S M Marti- nelli-Boneschi F | 2002 | Glia2002，39，： | 1 |
| 10 | OWL 2 modeling and reaso-ning with complex human activities 显示文摘 | Daniele Riboni Claudio Bettini | 2011 | Pervasive and MobileComputing2011，7，3： | 1 |
| 11 | Mode of delivery affects the bacterial community in the newborn gut显示文摘 | Biasucci G Rubini M Riboni S | 2010 | Early Hum Dev2010，86，1： | 1 |
| 12 | Hybrid reasoning in the CARE middleware for context awareness显示文摘 | Agostini A Bettini C Riboni D | 2009 | International Journal of Web Engineering and Technology2009，5，1： | 1 |
| 13 | Fasting hyper- glycema predicts the magnitude of postprandial hyperglycemia: im- plications for diabetes therapy 显示文摘 | CARROLL M F LZARD A RIBONI K | 2002 | Diabetes Care2002，25，7： | 1 |
| 14 | Biochemical markers predicting pre-term delivery in symptomatic patients: phosphorylated insulin- like growth factor binding protein-1 and fetal fibronectin 显示文摘 | Francesca Riboni Anna Vitulo | 2011 | Arch Gynecol Obstet2011，284，： | 1 |
| 15 | Mode of delivery affects the bacterial community in the newborn gut 显示文摘 | Biasucci G Rubini M Riboni S | 2010 | Early Hum Dev2010，86，1： | 1 |
| 16 | New mini-resectoscope:analysis of preliminary quality results in outpatient hysteroscopic polypectomy显示文摘 | Dealberti D Riboni F Prigione S | 2013 | Arch Gynecol Obstet2013，288，2： | 1 |
| 17 | A survey of context modelling and reasoning techniques 显示文摘 | Bettini C Brdiczka O Henricksen K Indulska J Nicklas D Ranganathan A Riboni D | 2010 | Pervasive and Mobile Computing2010，6，2： | 1 |
| 18 | Industrial section convenor's report显示文摘 | BARONE M RIBONI P | 2002 | Advanced Technology and Particle Physics2002，50，1： | 1 |
| 19 | Fasting hyperglycemia predicts the magnitude of postprandial hyperglycemia: implications for diabetes therapy 显示文摘 | Carroll MF Izard A Riboni K | 2002 | Diabetes Care2002，25，7： | 1 |
| 20 | Phosphorylated insulin-likegrowth factor binding protein-1 in cervical secretions and sonograph-ic cervical length in the prediction of spontaneous preterm delivery显示文摘 | PAatemoster D Riboni F Vitulo A | 2009 | Ultrasound Obstet Gynecol2009，34，： | 1 |
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