|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Repurposing metformin for the treatment of gastrointestinal cancer显示文摘Diabetes mellitus type 2 and cancer share many risk factors.The pleiotropic insulin-dependent and insulin-independent effects of metformin might inhibit pathways that are frequently amplified in neoplastic tissue.Particularly,modulation of inflammation,metabolism,and cell cycle arrest are potential therapeutic cancer targets utilized by metformin to boost the anti-cancer effects of chemotherapy.Studies in vitro and in vivo models have demonstrated the potential of metformin as a chemo-and radiosensitizer,besides its chemopreventive and direct therapeutic activity in digestive system(DS)tumors.Hence,these aspects have been considered in many cancer clinical trials.Case-control and cohort studies and associated meta-analyses have evaluated DS cancer risk and metformin usage,especially in colorectal cancer,pancreatic cancer,and hepatocellular carcinoma.Most clinical studies have demonstrated the protective role of metformin in the risk for DS cancers and survival rates.On the other hand,the ability of metformin to enhance the actions of chemotherapy for gastric and biliary cancers is yet to be investigated.This article reviews the current findings on the anti-cancer mechanisms of metformin and its apparatus from pre-clinical and ongoing studies in DS malignancies. | Ademar Dantas Cunha Júnior Arinilda Campos Bragagnoli Felipe Osório Costa JoséBarreto Campello Carvalheira | 2021 | World Journal of Gastroenterology2021，27，17： | 5 |
| 2 | Degradation of Metalaxyl and Folpet by Filamentous Fungi Isolated From Portuguese (Alentejo) Vineyard Soils显示文摘 | M. Rosário Martins Pablo Pereira Nelson Lima Júlio Cruz-Morais | 2013 | Archives of Environmental Contamination and Toxicology2013，，1： | 2 |
| 3 | How to manage inflammatory bowel disease during the COVID-19 pandemic:A guide for the practicing clinician显示文摘Managing inflammatory bowel disease(IBD)during the coronavirus disease 2019(COVID-19)pandemic has been a challenge faced by clinicians and their patients,especially concerning whether to proceed with biologics and immunosuppressive agents in the background of a global outbreak of a highly contagious new coronavirus(severe acute respiratory syndrome coronavirus 2,SARS-CoV-2).The knowledge about the impact of this virus on patients with IBD,although it is still scarce,is rapidly evolving.In particular,concerns surrounding medications’impact for IBD on the risk of acquiring SARS-CoV-2 infection or developing COVID-19,and potentially exacerbate viral replication and the COVID-19 course,are a current thinking of both practicing clinicians and providers caring for patients with IBD.Managing patients with IBD infected with SARS-CoV-2 depends on both the clinical activity of the IBD and the occasional development and severity of COVID-19.In this review,we summarize the current data regarding gastrointestinal involvement by SARS-CoV-2 and pharmacologic and surgical management for IBD concerning this infection,and the COVID-19 impact on both the patient's psychological functioning and endoscopy services,and we concisely summarize the telemedicine roles during the COVID-19 pandemic. | Júlio Maria Fonseca Chebli Natália Sousa Freitas Queiroz Adérson Omar Mourão Cintra Damião Liliana Andrade Chebli Márcia Henriques de Magalhães Costa Rogério Serafim Parra | 2021 | World Journal of Gastroenterology2021，27，11： | 2 |
| 4 | Comparison of intraocular treatment of DMTU and SOD following retinal ischemia in rats显示文摘 | Rios L Cluzel J Vennat JC | 1999 | J Ocul pharmacol Ther1999，15，6： | 2 |
| 5 | Robust linear regression taking into account errors in the predictor and response variables 显示文摘 | del Rio F J Riu J Rius F X | 2001 | Analyst2001，126，7： | 2 |
| 6 | Energetic-protein supplementation in the last 60 days of gestation improves performance of beef cows grazing tropical pastures显示文摘Background: Nutrition is one of the most important factors that affect animal performance, and it therefore also impacts on financial results in beef systems. In this way, finding the best strategy for feeding supplements is of paramount importance. Aiming to evaluate the effect of supplement feeding strategies for beef cows in the last third of gestation, two experiments were conducted. In Experiment 1, 35 pregnant Nellore cows were assigned to a completely randomized design with four treatments: control, which received no supplement; supplementation for the last 30 d of gestation(30-d; 3.0 kg/d); supplementation for the last 60 d of gestation(60-d; 1.5 kg/d); or supplementation for the last 90 d of gestation(90-d; 1.0 kg/d). All supplemented treatments received the same total amount of supplement throughout the experiment: 90 kg(20% of crude protein). A second experiment(Experiment 2) was delineated to evaluate the effects of the amounts offered in Experiment 1 on intake and metabolism. Four multiparous pregnant Nellore cows were assigned to a 4 × 4 Latin square design, with periods of15 d each.Results: There was a linear effect of the number of days of supplementation on calving body weight(BW; P < 0.05)and a quadratic effect on BW change from parturition to d 31 post-calving(P < 0.05), with cows on the 60-d strategy losing less BW post-calving. No difference was found in offspring birth BW(P > 0.10). A significant linear effect on interval from parturition to conception(P < 0.05) was observed, with the highest calving to conception interval being observed in the 90-d strategy. The level of supplementation did not affect forage intake or neutral detergent fiber digestibility(P > 0.10). Nitrogen excreted through urine tended to increase linearly with the level of supplementation(P < 0.10).Conclusion: Providing 1.5 kg of supplement during the last 60 d of gestation improves cow performance after calving, reducing the magnitude of BW lost, and reduces the number of days from calving to re-conception in the following breeding season compared to the usually recommended period of supplementation of 90 d pre-partum. | Aline Gomes da Silva Mário Fonseca Paulino Edenio Detmann Henrique Jorge Fernandes Lincoln da Silva Amorim Román Enrique Maza Ortega Victor Valério de Carvalho Josilaine Aparecida da Costa Lima Felipe Henrique de Moura Mariana Benevides Monteiro Jéssika Almeida Bitencourt | 2018 | Journal of Animal Science and Biotechnology2018，9，1： | 2 |
| 7 | Effect of diamond shapes and associated thermal boundary resistance on thermal conductivity of diamond - base composites 显示文摘 | Flaquer J Rios A | 2007 | Comput mater Sci2007，10，： | 1 |
| 8 | Prospective study of postoperative complications after total thyroideczomy for muhinodular goiters by surgeons with experience in endocrine surgery显示文摘 | Rios Zambudio A Rodriguez J Riquelme J | 2004 | Ann Surg2004，240，： | 1 |
| 9 | Discovering regulatory elements in non-coding sequences by analysis of spaced dyads 显示文摘 | Rios AF Collado-Vides J | 2000 | Nucleic Acids Res2000，28，8： | 1 |
| 10 | Heavy metal vaporization and abatement during thermal treatment of modified wastes显示文摘 | RIO S VERWILGHEN C RAMAROSON J NZIHOU A SHARROCK P | 2007 | Journal of Hazardous Materials2007，148，3： | 1 |
| 11 | Wavefront-guided ablation with Bausch and Lomb Zyoptix for retreatments after laser in situ keratomileuswas for myopia显示文摘 | Castanera J Serra A Rios C | 2004 | J Refract Surg2004，20，5： | 1 |
| 12 | A Whole genome screen for association with multiple sclerosis in Portuguese patients显示文摘 | Santos M Pinto-Basto J Rio ME | 2003 | J Neuroimmunol2003，143，： | 1 |
| 13 | Heat transfer enhancement in oscillatory flows of newtonian and viscoe lastic fluids显示文摘 | Lambert A A Cuevas S del Rio J A | 2009 | International Journal of Heat and Mass Transfer2009，52，： | 1 |
| 14 | A chemical, morphological, and electrochemical (XPS, SEM/EDX, CV, and EIS) analysis of electrochemically modified electrode surfaces of natural chalcopyrite (CuFeS2) and pyrite (FeS2) in alkaline solutions显示文摘 | VELASQUEZ P LEINEN D PASCUAL J RAMOS- BARRADO J R GREZ P GOMEZ H SCHREBLER R DEL RiO R CORDOVA R | 2005 | Journal of Physical Chemistry B2005，109，1： | 1 |
| 15 | Improving the Cercospora leaf spot management model for sugar beet in Minnesota and North Dakota 显示文摘 | Khan J Del Rio L E Nelson R | 2007 | Plant Disease2007，91，9： | 1 |
| 16 | Chemical composition of lipophilic extractives from jute (Corchorus capsularis)fibers used for manufacturing of high-quality paper pulps 显示文摘 | Rio Andrade J C Marques G Rodriguez Garcia M I | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 17 | The food contami- nant deoxynivalenol, decreases intestinal barrier permeability and reduces claudin expression 显示文摘 | Pinton P Nougayrede J P Del rio J C | 2009 | Toxicol Appl Pharmacol2009，237，： | 1 |
| 18 | Global kinetic evaluation during the reduction of C0WO4with methane for the production of hydrogen显示文摘 | De Los Rios Castillo T Salinas G J Lopez O A | 2013 | International Journal of Hydrogen Energy2013，38，12： | 1 |
| 19 | Analyzing consistency of independent components: an fMRI illustration 显示文摘 | Ylipaavalniemi J Vige rio R | 2008 | NeuroImage2008，39，1： | 1 |
| 20 | The role of ecological theory and practice in poverty alleviation and environmental conservation 显示文摘 | DeClerck F Ingram J C Del Rio C M R | 2006 | The Ecological Society of America2006，4，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员