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| 1 | Fetal plasma erythropoietm contration in severe growth retardation显示文摘 | Snijder RIM Abbas A Melby RM | 1993 | Am J Obstet Gynecol1993，168，2： | 1 |
| 2 | Trends in breast cancer screening and diagnosis显示文摘 | Rim A Chellman-Jefers M | 2008 | Cleve Clin J Med2008，75，1： | 1 |
| 3 | Application of enzymes for textile fi- bres processing 显示文摘 | Rim A Margarida C Artur CP | 2008 | Biocatalysis and Biotransformation2008，26，5： | 1 |
| 4 | How should we screen for breast cancer? MammograPhy, Ultrasonography, MRI显示文摘 | Nemec CF Listinsky J Rim A | 2007 | Cleve Clin J Med2007，45，74： | 1 |
| 5 | Guideline for using breast magnetic resonance imaging to evaluate implant integrity显示文摘 | Kreymerman P Patrick RJ Rim A | 2009 | Ann Plast Surg2009，62，4： | 1 |
| 6 | Combined treatment with silver ions and organic acid enhances growth-inhibition of Escherichia coli O157 : H7 显示文摘 | Jo S C Rim A R Park H J | 2007 | Food Control2007，18，10： | 1 |
| 7 | Physicians Who Use Social Media and Other Intemet-Based Communication Technologies显示文摘 | Cooper C P Gelb C A Rim S H | 2012 | Journal of the American Medical Informatics Association2012，19，6： | 1 |
| 8 | Antioxidant activity of extracts from Acanthopanax senticosus 显示文摘 | Park H R Park E Rim A R | 2006 | Afr J BiotechnoI2006，5，23： | 1 |
| 9 | Intake of carotenoids and retinol in relation to risk of prostate cancer显示文摘 | GIOVANNUCCI E ASCHERIO A RIM E B | 1995 | J Nat| Cancer Inst1995，87，23： | 1 |
| 10 | Guidelines for using breast magnetic resonance imaging to evaluate implant integrity显示文摘 | Kreymerman P Patrick RJ Rim A | 2009 | Ann Plast Surg2009，62，： | 1 |
| 11 | Silver ion oscillation through calyx azacrown tube 显示文摘 | Kin J S Yang S H Rim J A | 2001 | Tetrahedron Letters2001，42，： | 1 |
| 12 | Elevated day FSH/LH ratio due to low LH concentrations predicts reduced ovarian response显示文摘 | SH RIM A ELIZUR SE SEIDM AN DS | 2006 | Reprod Biom ed Online2006，12，4： | 1 |
| 13 | Optimal and heuristic algorithms for solving the binding problem 显示文摘 | Rim M Majumdar A | 1994 | IEEE Transactions on VLSI Systems1994，2，7： | 1 |
| 14 | The effect of salinity on the germination, plant growth and essential oil content of Thym us broussonetii Boiss: An endemic species in Morocco显示文摘 | Rim B Abderrahmane R Abdelaziz A | 2009 | Indian Journal of Agricutural Research2009，4，1： | 1 |
| 15 | How should we screen for breast cancer? Mammography,ultrasonography,MRI显示文摘 | Nemec CF Listinsky J Rim A | 2007 | Cleve Clin J Med2007，4，12： | 1 |
| 16 | Antioxidant activity of extracts from Acanthopanax senticosus 显示文摘 | PARK H R PARK E RIM A R | 2006 | Mr J Biotechnol2006，5，23： | 1 |
| 17 | Determination of urinary enzymes as a marker of early renal damage in diabetic patients 显示文摘 | Mohamadr Karakani A Asgarzadelr Haghighi S Ghazrhansa- rim | 2007 | J Clin Lab Anal2007，21，6： | 1 |
| 18 | Passivation process for superfine aluminum powders obtained by electrical explosion of wires显示文摘 | Young-Soon Kwon Alexander A Gromov Alexander P Ilyin Geun-Hie Rim | 2003 | Applied Surface Science2003，，1： | 1 |
| 19 | A novel cytokine consisting of the p40 and EBI3 subunits suppresses experimental autoimmune arthritis via reciprocal regulation of Th17 and Treg cells显示文摘OBJECTIVE:The interleukin(IL)-12 cytokine family is closely related to the development of T helper cells,which are responsible for autoimmune disease enhancement or suppression.IL-12 family members are generally heterodimers and share threeα-subunits(p35,p19,and p28)and twoβ-subunits(p40 and EBI3).However,aβ-sheet p40 homodimer has been shown to exist and antagonize IL-12 and IL-23 signaling 1.Therefore,we assumed the existence of a p40-EBI3 heterodimer in nature and sought to investigate its role in immune regulation.METHODS:The presence of the p40-EBI3 heterodimer was confirmed by ELISA,immunoprecipitation,and western blotting.A p40-EBI3 vector and p40-EBI3-Fc protein were synthesized to confirm the immunological role of this protein in mice with collageninduced arthritis(CIA).The anti-inflammatory effects of p40-EBI3 were analyzed with regard to clinical,histological,and immune cell-regulating features in mice with CIA.RESULTS:Clinical arthritis scores and the expression levels of proinflammatory cytokines(e.g.,IL-17,IL-1β,IL-6,and TNF-α)were significantly attenuated in p40-EBI3-overexpressing and p40-EBI3-Fc-treated mice with CIA compared to vehicle-treated mice with CIA.Structural joint damage and vessel formation-related gene expression were also reduced by p40-EBI3 heterodimer treatment.In vitro,the p40-EBI3-Fc protein significantly suppressed the differentiation of Th17 cells and reciprocally induced CD4+CD25+Foxp3+(regulatory T)cells.p40-EBI3 also inhibited osteoclast formation in a concentrationdependent manner.CONCLUSION:In this study,p40-EBI3 ameliorated proinflammatory conditions both in vivo and in vitro.We propose that p40-EBI3 is a novel anti-inflammatory cytokine involved in suppressing the immune response through the expansion of Treg cells and suppression of Th17 cells and osteoclastogenesis. | Seon-Yeong Lee Su-Jin Moon Young-Mee Moon Hyeon-Beom Seo Jun-Geol Ryu A Ram Lee Chae Rim Lee Da-Som Kim Yang-Mi Her Jeong Won Choi Seung-Ki Kwok Sung-Hwan Park Mi-La Cho | 2022 | Cellular & Molecular Immunology2022，19，1： | 1 |
| 20 | Pyrene-armed- calix azacrowns as new fluorescent ionophores : ' molecular taekowndo ' process via fluorescence change 显示文摘 | Kim J S Shon O J Rim J A | 2002 | J Org Chem2002，67，： | 1 |
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