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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | DNA vaccination of infants in the presence of maternal antibody: a measles model in the primate显示文摘 | Mary Premenko-Lanier Paul A Rota Gary Rhodes David Verhoeven Dan H Barouch Nicholas W Lerche Norman L Letvin William J Bellini Michael B McChesney | 2003 | Virology2003，，1： | 2 |
| 3 | Predicion of incompressible flow in a labyrinth seal 显示文摘 | RHODE D L DEMKO J A TRAEGNER U K | 1986 | ASME Journal of Fluids Engineering1986，108，： | 1 |
| 4 | The Prediction andMeasurement of incompressible flow in a labyrinth seal 显示文摘 | DEMKO J A MORRISON G L RHODE D L | 1980 | ASME Journal of Engineering Gas Turbines Power1980，111，4： | 1 |
| 5 | Influence of land use on water quality of a diverse New England watershed 显示文摘 | Rhode A L Newton R M Pufall A A | 2001 | Environmental Science and Technology2001，35，： | 1 |
| 6 | Pathology of neonatal calf diarrhea induced by a coronavirus-like agent显示文摘 | Mebus C A Stair E L Rhodes M B | 1973 | Vet Pathol1973，10，： | 1 |
| 7 | The effects of dimethylated and alkylated polycycfic aromatic hydrocarbons on the embryonic development of the Japanese medaka 显示文摘 | Rhodes S M Farwell A Hewitt L M etal | 2005 | Ecotoxicology and Environmental Safety2005，60，3： | 1 |
| 8 | Measuring the efficiency of decision making units显示文摘 | Chames A Cooper W W Rhodes E L | 1978 | European Journal of OperationalResearch1978，2，6： | 1 |
| 9 | Effect of shaft rotation on the incompressible flow in a labyrinth seal 显示文摘 | Demko J A Morrision G L Rhode D L | 1990 | Journal of Propulsion and Power1990，6，2： | 1 |
| 10 | Measuring the Effi- ciency of Decision Making Units 显示文摘 | CHARNES A W W COOPER E L RHODES | 1978 | European Journal of Opera- tional Research1978，，2： | 1 |
| 11 | Ultrathin, protective coatings of poly(o-phenylenediamine) as electrochemical proton gates t Making mesoporous MnOz nanoarchitectures stable in acid electrolytes显示文摘 | Long J W Rhodes C P Young A L | 2003 | Nano Letters2003，3，8： | 1 |
| 12 | Production of bacteriolytic enzymes and degradation of bacteria by filamentous fungi 显示文摘 | GRANT W D RHODES L L PROSSER B A | 1986 | Journal of General Microbiology1986，132，： | 1 |
| 13 | Measuring the Efficiency of Decision Making Units 显示文摘 | Chames A Cooper W W Rhodes E L | 1978 | European Journal of Operational Research1978，，2： | 1 |
| 14 | Disappearance of diuron from cotton field soil显示文摘 | Dalton R L Evans A W Rhodes R C | 1996 | Weeds1996，14，： | 1 |
| 15 | Measuring the effi- ciency of decision making units 显示文摘 | Charnes A Cooper W W Rhodes E L | 1978 | European Journal of Operational Research1978，，2： | 1 |
| 16 | Injecting equipment sharing among injecting drug users in Togliatti City, Russian Federation: maximizing the protective effects of syringe distribution 显示文摘 | Rhodes T Judd A Mikhailova L | 2004 | J Acquir Immune Defic Syndr2004，35，3： | 1 |
| 17 | FITC-conjugated lectins as a tool for differentiationg between toxic and non-toxic marine dinoflagellates显示文摘 | Rhodes L L Haywood A J Fountain D W | 1995 | N Z J Mar Freshw Res1995，29，： | 1 |
| 18 | Pathology of neonatal calf diarrhea induced by a coronavirus-like agent显示文摘 | Mebus C A Stair E L Rhodes M B | | 0，，： | 1 |
| 19 | Measuring the efficiency ofdecision making units显示文摘 | CHARNES A COOPER W W RHODES E L | 1978 | European Journal of Operational Research1978，2，： | 1 |
| 20 | Cyanobacterial ecology across environmental gradients and spatial scales in China's hot and cold deserts显示文摘 | WARREN-RHODES K A RHODES K L BOYLE L N | 2007 | FEMS Microbiology Ecology2007，61，3： | 1 |
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