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129篇 您的检索式:作者名="Revilla M"
    题名 作者 年代 出处 被引量
1Aplastic anemia and severe pancytopenia during treatment with peg-interferon,ribavirin and telaprevir for chronic hepatitis C显示文摘Telaprevir and Boceprevir are the first direct acting antivirals approved for chronic hepatitis C in combination with peg-interferon alfa and ribavirin.Pancytopenia due to myelotoxicity caused by these drugs may occur,but severe hematological abnormalities or aplastic anemia(AA) have not been described.We collected all cases of severe pancytopenia observed during triple therapy with telaprevir in four Spanish centers since approval of the drug in 2011.Among 142 cirrhotic patients receiving treatment,7 cases of severe pancytopenia(5%) were identified and three were consistent with the diagnosis of AA.Mean age was 59 years,five patients had compensated cirrhosis and two patients had severe hepatitis C recurrence after liver transplantation.Severe pancytopenia was diagnosed a median of 10 wk after the initiation of therapy.Three patients had pre-treatment hematological abnormalities related to splenomegaly.In six patients,antiviral treatment was interrupted at the onset of hematological abnormalities.Two patients died due to septic complications and one patient due to acute alveolar hemorrhage.The remaining patients recovered.Severe pancytopenia and especially AA,are not rare during triple therapy with telaprevir in patients with advanced liver disease.Close monitoring is imperative in this setting to promptly detect serious hematological disorders and to prevent further complications.Sabela Lens Jose L Calleja Ana Campillo Jose A Carrion Teresa Broquetas Christie Perello Juan de la Revilla Zoe Marino Maria-Carlota Londono Jose M Sanchez-Tapias Alvaro Urbano-Ispizua Xavier Forns 2015World Journal of Gastroenterology2015,21,17:4
2Building dynamic capabilities in product de- velopment: How do contextual antecedents matter? 显示文摘Isabel M Prieto Elena Revilla Beatriz Rodr?' guez- Prado 2009Scandinavian Journal of Management2009,25,:1
3Callus induction and a preliminary attempt to obtain cell suspensions from embryos and levels of Juglans regia L 显示文摘Rodriguez R Revilla M A Perez C 1987Acta Hort (ISHS)1987,12,:1
4Effect of locust bean/xanthan gum addition and replacement of pork fat with olive oil on the quality characteristicsof low-fat frankfurters显示文摘LURUENA-MARTINEZ M A VIVAR-QUINTANA A M REVILLA I 2004Meat Science2004,68,3:1
5Correlation of ultrasound bone velocity with dual energy X-ray bone absorptionmetry in rat bone specimens显示文摘Amo C Revilla M Hermandez ER 1996Invest R adiol1996,31,2:1
6Analysis of several phenolic compounds with potential antioxidant properties in grape extracts and wines by high- performance liquid chromatography - photodiode array detection without sample preparation显示文摘 Ryan J M 2000J Chrom2000,,:1
7Fx vivo ersponse to sapirin differs in stroke patients with single or recurrent events:a pilot study显示文摘Chamorro A Escolar G Revilla M 1999J Nenrol Sci1999,171,:1
8Urea analysis in coastal waters:Comparison of enzymatic and direct methods显示文摘Revilla M Alexander J Glibert PM 2005Limnology and Oceanography:Methods2005,3,7:1
9Anthocyanin composition of cabernet sauvignon and tempranillo grapes at different stages of ripening显示文摘Ryan J M Revilla E 2003J Agric Food Chem2003,51,11:1
10Comparison of several procedures used for the extraction of anthocyanins from red grapes 显示文摘Revilla E Ryan J M Martn-Ortega G 1998Agric Food Chem1998,,:1
11Effect of maternal diabetes on human and rat fetal development显示文摘POLANCO A C REVILLA M C PALOMINO M A 2005Ginecol Obstet Mex2005,73,10:1
12Inhibition of nuclear fac- tor kappaB activation by a virus-encoded IkappaB-like protein 显示文摘Revilla Y Callejo M Rodrfguez JM 1998J Biol Chem1998,273,9:1
13Effect of locust bean/xanthan gum addition and replacement of pork fat with olive oil on the quality characteristics of low-fat frankfurters显示文摘M A Luruena-Martinez A M Vivar-Quintana I Revilla 2004Meat Science2004,68,:1
14Managing the knowledge paradox in product development显示文摘Prieto I M Revilla E Rodrguez-Prado B 2009Journal of Knowledge Management2009,3,13:1
15Prediction of sensory attributes of cheese by near-infrared spectroscopy显示文摘GONZALEZ-MARTíN M I SEVERIANO-PEREZ P REVILLA I etal 2011Food Chemistry2011,127,1:1
16A general strategy for the isolation of mesophyll protoplasts from delicious fruit and nut tree species 显示文摘 OCHATT S J Doughty S 1987Plant Science1987,50,:1
17Analysis of several phenolic compounds with potential antioxidant properties in grape extracts and wines by high-performance liquid chromatography photodiode array detection without sample preparation显示文摘REVILLA E RYAN M 2000J Chromatography A2000,881,12:1
18Crush fracture syndrome in se-nile osteoporosis: a nutritional consequence? 显示文摘Rico H Revilla M Villa LF 1992J Bone Miner Res1992,,3:1
19Competitive Learning in Informatics: The UVa Online Judge Experience 显示文摘Revilla M A Manzoor S Liu Rujia 2008Olympiads in Informatics2008,,2:1
20Pbenotypie characterization of pig IFN-γ-producing lym- phocytes by flow cytometry 显示文摘Rodriguez-Carreno M P Lopez-Fuertes L Revilla C 2002Journal of Immunological Methos2002,259,12:1
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