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| 1 | The lipin protein family: Dual roles in lipid biosynthesis and gene expression显示文摘 | Karen Reue Peixiang Zhang | 2007 | FEBS Letters2007，，： | 3 |
| 2 | Multifunctional lipid metabolism proteins显示文摘 | CSAKI L S REUE K | 2010 | Annu Rev Nutr2010，30，： | 1 |
| 3 | Hormone-sensitive lipase overexpression increases cholesteryl ester hydrolysis in macrophage foam cells 显示文摘 | Escary JL Choy HA Reue K | 1998 | Arterioscler Thromb Vasc Biol1998，18，： | 1 |
| 4 | Metabolic syndrome:from epidemiology to system biology显示文摘 | Lusis A J Attie AD Reue K | 2008 | Nat Rev Genet2008，9，11： | 1 |
| 5 | Lipins, lipinopathies, and the modulation of cellular lipid storage and signaling显示文摘 | Lauren S. Csaki Jennifer R. Dwyer Loren G. Fong Peter Tontonoz Stephen G. Young Karen Reue | 2013 | Progress in Lipid Research2013，，3： | 1 |
| 6 | lapin , a lipodystrophy and obesity gene 显示文摘 | Phan J Reue K | 2005 | Cell Metab2005，1，1： | 1 |
| 7 | Metabolic consequences of lipodystrophy in mouse models显示文摘 | Reue K Pban J | 2006 | Cm''r Opin Clin Nutr Metab Care2006，，9： | 1 |
| 8 | Lipins: multifunctional lipid metabolism proteins显示文摘 | Csaki L S Reue K | 2010 | Annu Rev Nutr2010，30，： | 1 |
| 9 | Lipin expression preceding peroxisome pmliferator-activated receptor-γ is critical for adipogenesis in vivo and in vitro 显示文摘 | Phan J P6teffy M Reue K | 2004 | J Bid Chem2004，279，29： | 1 |
| 10 | Cross-species analyses implicate Lipinl involvement in human glucose metabolism 显示文摘 | Suviolahti E Reue K Cantor R M | 2006 | Hum Mol Genet2006，15，： | 1 |
| 11 | Ath-1, a gene determining atherosclerosis susceptibility and high density lipoeprotein levels in mice 显示文摘 | Paigen B Mitchell D Reue K | 1987 | Proc Natl Acad Sci USA1987，84，11： | 1 |
| 12 | Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (rid) gene 显示文摘 | Reue K Xu P Wang X P | 2000 | Lipid Res2000，41，： | 1 |
| 13 | Biochemistry, physiology, and genetics of GPAT, AGPAT, and lipin enzymes in triglyceride synthesis 显示文摘 | TAKEUCHI K REUE K | 2009 | Am J Physiol Endocrinol Metab2009，296，6： | 1 |
| 14 | Biochemistry,physiology,and genetics of GPAT,AGPAT,and lipin enzymes in triglyceride synthesis显示文摘 | Takeuchi K Reue K | 2009 | Am J Physiol Endocrinol Metab2009，296，： | 1 |
| 15 | Cross-species analyses implicate Lipin 1 involvement in human glucose metabolism显示文摘 | Suviolahti E Reue K Cantor R M | 2006 | Hum Mol Genet2006，15，： | 1 |
| 16 | The Lipin protein family : Dual roles in lipid biosynthesis and gene expression 显示文摘 | Reue K Zhang P X | 2008 | FEBS Lett2008，582，1： | 1 |
| 17 | Cross-species analyses implicate Lipinl involvement in human glucose metabolism 显示文摘 | SUVIOLAHTI E REUE K CANTOR R M | 2006 | Human Molecular Ge- netics2006，15，3： | 1 |
| 18 | Suppressing fatty acid synthase by type Ⅰ interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2显示文摘SARS-CoV-2 is an emerging viral pathogen and a major global public health challenge since December of 2019, with limited effective treatments throughout the pandemic.As part of the innate immune response to viral infection, type Ⅰ interferons(IFN-Ⅰ) trigger a signaling cascade that culminates in the activation of hundreds of genes, known as interferon stimulated genes(ISGs), that collectively foster an antiviral state.We report here the identification of a group of type Ⅰ interferon suppressed genes,including fatty acid synthase(FASN), which are involved in lipid metabolism.Overexpression of FASN or the addition of its downstream product, palmitate, increased viral infection while knockout or knockdown of FASN reduced infection.More importantly, pharmacological inhibitors of FASN effectively blocked infections with a broad range of viruses, including SARS-CoV-2 and its variants of concern.Thus, our studies not only suggest that downregulation of metabolic genes may present an antiviral strategy by type Ⅰ interferon, but they also introduce the potential for FASN inhibitors to have a therapeutic application in combating emerging infectious diseases such as COVID-19. | Saba R.Aliyari Amir Ali Ghaffari Olivier Pernet Kislay Parvatiyar Yao Wang Hoda Gerami Ann-Jay Tong Laurent Vergnes Armin Takallou Adel Zhang Xiaochao Wei Linda D.Chilin Yuntao Wu Clay F.Semenkovich Karen Reue Stephen T.Smale Benhur Lee Genhong Cheng | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 1 |
| 19 | Lipin expression preceding peroxisome proliferator-activated receptorgamma is critical for adipogenesis in vivo and in vitro显示文摘 | PHAN J PETERFY M REUE K | 2004 | J Biol Chem2004，279，29： | 1 |
| 20 | Lipin, a lipodystrophy and obesity gene 显示文摘 | Phan J Reue k | 2005 | Cell Metab2005，1，： | 1 |
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