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您的检索式：作者名="Reuben J.Peters"
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| 1 | Dynamic evolution of terpenoid biosynthesis in the Lamiaceae显示文摘With the increasing accessibility of whole-genome sequencing it has become standard practice to apply such an approach to investigation of plants with important and/or interesting natural products.In part,this reflects recognition that plants have occasionally rearranged or shuffled their genes to generate biosynthetic gene clusters(BGCs)for certain natural products(Smit and Lichman,2022;Zhan et al.,2022). | Zhibiao Wang Reuben J.Peters | 2023 | Molecular Plant2023，16，6： | 0 |
| 2 | Oryzalexin S biosynthesis:a cross-stitched disappearing pathway显示文摘Rice produces many diterpenoid phytoalexins and,reflecting the importance of these natural products in this important cereal crop plant,its genome contains three biosynthetic gene clusters(BGCs)for such metabolism.The chromosome 4 BGC(c4BGC)is largely associated with momilactone production,in part due to the presence of the initiating syn-copalyl diphosphate(CPP)synthase gene(OsCPS4).Oryzalexin S is also derived from syn-CPP.However,the relevant subsequently acting syn-stemarene synthase gene(OsKSL8)is not located in the c4BGC.Production of oryzalexin S further requires hydroxylation at carbons 2 and 19(C2 and C19),presumably catalyzed by cytochrome P450(CYP)monooxygenases.Here it is reported the closely related CYP99A2 and CYP99A3,whose genes are also found in the c4BGC catalyze the necessary C19-hydroxylation,while the closely related CYP71Z21 and CYP71Z22,whose genes are found in the recently reported chromosome 7 BGC(c7BGC),catalyze subsequent hydroxylation at C2α.Thus,oryzalexin S biosynthesis utilizes two distinct BGCs,in a pathway cross-stitched together by OsKSL8.Notably,in contrast to the widely conserved c4BGC,the c7BGC is subspecies(ssp.)specific,being prevalent in ssp.japonica and only rarely found in the other major ssp.indica.Moreover,while the closely related syn-stemodene synthase OsKSL11 was originally considered to be distinct from OsKSL8,it has now been reported to be a ssp.indica derived allele at the same genetic loci.Intriguingly,more detailed analysis indicates that OsKSL8(j)is being replaced by OsKSL11(OsKSL8i),suggesting introgression from ssp.indica to(sub)tropical japonica,with concurrent disappearance of oryzalexin S production. | Le Zhao Richard Oyagbenro Yiling Feng Meimei Xu Reuben J.Peters | 2023 | aBIOTECH2023，4，1： | 0 |
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