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| 1 | A longitudinal assessment of retinal function and structure in the APP/PS1 transgenic mouse model of Alzheimer’s disease显示文摘Background:A great body of evidence suggests that there are retinal functional and structural changes that occur in Alzheimer’s disease(AD).However,whether such changes are primary or secondary remains to be elucidated.We studied a range of retinal functional and structural parameters in association with AD-specific pathophysiological markers in the double transgenic APP/PS1 and control mice across age.Methods:Electroretinogram(ERG)and optical coherence tomography(OCT)was performed in APP/PS1 and wild type(WT)control mice every 3 months from 3 to 12 months of age.For functional assessment,the a-and b-wave of the ERG,amplitude of oscillatory potentials(OP)and the positive scotopic threshold response(pSTR)were quantified at each time point.For structural assessment,the inner and outer retinal thickness was segmented and measured from OCT scans.Episodic memory was evaluated at 6,9 and 12 months of age using the novel object recognition test.Amyloid beta(Aβ)distribution in the hippocampus and the retina were visualised at 3,6 and 12 months of age.Interand intra-group analysis was performed to study rate of change for each parameter between the two groups.Results:Inter-group analysis revealed a significant difference in b-wave and OPs of APP/PS1 compared to WT controls starting from 3 months(p<0.001).There was also a significant difference in the amplitude of pSTR between the two groups starting from 6 months(p<0.001).Furthermore,a significant difference in the inner retinal thickness,between the two groups,was observed starting from 9 months(p<0.001).Conclusions:We observed an age-related decline in retinal functional and structural parameters in both APP/PS1 and WT controls,however,inter-group analysis revealed that inner retinal functional and structural decline is exacerbated in APP/PS1 mice,and that retinal functional changes precede structural changes in this strain.Further studies are required to confirm whether such phenomenon occurs in humans and if studying retinal functional changes can aid-in early assessment of AD. | Dana Georgevsky Stephanie Retsas Newsha Raoufi Olga Shimoni S.Mojtaba Golzan | 2019 | Translational Neurodegeneration2019，8，1： | 3 |
| 2 | Barriers to using research evidence in nursing prac-tice显示文摘 | Retsas A | 2000 | Journal of Advanced Nursing2000，31，3： | 1 |
| 3 | Barriers to using research evidence in nursing practice 显示文摘 | Retsas A | 2000 | J Advanced Nursing2000，31，3： | 1 |
| 4 | Prognostic factors of cutaneous melanoma and a new staging system proposed by the American Joint Committee on Cancer (AJCC): validation in a cohort of 1284 patients显示文摘 | Retsas S Henry K Mohammed MQ | 2002 | Eur J Cancer2002，38，： | 1 |
| 5 | New colorimetric cytotoxicity assay for anticancer-drug screening显示文摘 | Philip S Retsa S Dominic S | 1990 | J Natl Cancer Inst1990，82，： | 1 |
| 6 | Barrier to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | Journal of Advanced Nursing2000，31，59： | 1 |
| 7 | Barriers to using research evidence in nursing practice 显示文摘 | Retsas A | 2000 | J Adu Nuts2000，31，3： | 1 |
| 8 | Blood stream infections and sepsis in Greece: over-time change of epidemiology and impact of de-escalation on final outcome 显示文摘 | Koupetori M Retsas T Antonakos N | 2014 | BMC Infectious Diseases2014，14，： | 1 |
| 9 | What is the Optimal Therapy of Brain Metastases?显示文摘 | Y. Marcou C. Lindquist C. Adams S. Retsas P.N. Plowman | 2001 | Clinical Oncology2001，，2： | 1 |
| 10 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
| 11 | Barriers to using research evidencein nursing practice 显示文摘 | Retsas A | 2000 | J Advanced Nursing2000，31，3： | 1 |
| 12 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Advanced Nursing2000，31，3： | 1 |
| 13 | Barrier to using reseach evidence in nursing practice显示文摘 | Retsas A | 2000 | Adv N urs2000，31，3： | 1 |
| 14 | Bloodstream infections and sepsis in Greece:over-time change of epidemiology and impact of de-escalation on final outcome 显示文摘 | Koupetori M Retsas T Antonakos N | 2014 | BMC Infect Dis2014，14，： | 1 |
| 15 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
| 16 | Barriers to using research evidence in nursing prac- tice 显示文摘 | Retsas A | 2000 | J Adv Nuts2000，31，3： | 1 |
| 17 | Barriers to using research evidencein nursing practice 显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
| 18 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
| 19 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
| 20 | Barriers to using research evidence in nursing practice显示文摘 | Retsas A | 2000 | J Adv Nurs2000，31，3： | 1 |
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