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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Role of the JNK pathway in NMDA-mediated excitotoxicity of cortical neurons 显示文摘 | Centeno C Repici M Chatton JY | 2007 | Cell Death Differ2007，14，2： | 1 |
| 3 | A randomized prospective comparison of self-expandable plastic stents and partially covered self-expandable metal stents in the palliation of malignant esophageal dysphagia显示文摘 | Conio M Repici A Battaglia G | 2007 | Am J Gastroenterol2007，102，11： | 1 |
| 4 | Early arid late out- come of patients with obstructing colorectal cancer treat- ed by stenting and elective surgery:a comparison with e- mergency surgery and patients operated without obstruc- tive symptoms 显示文摘 | Repici A Conio M Caronna S | 2004 | Gastrointest Endosc2004，59，5： | 1 |
| 5 | Insulated-tip knife endoscopic mucosal resection of large eolorectal polyps un- suitable for standard polypectomy 显示文摘 | Repici A Conio M De Angelis C | 2007 | Am J Gastroenterol2007，102，8： | 1 |
| 6 | The natural history of gastroin- testinal subepithelial tumors arising from muscularis propria: an endo- scopic ultrasound survey 显示文摘 | Bruno M Carucci P Repici A | 2009 | J Clin Gastroenterol2009，43，9： | 1 |
| 7 | New design esopha- geal stents for the palliation of dysphagia from esophageal or gas- tric cardia cancer: a randomized trial显示文摘 | Verschuur E M Repici A Kuipers E J | 2008 | Am J Gastroenterol2008，103，30： | 1 |
| 8 | Insulatedtip knifeen- doscopic mucosal resection of large eolorectal polyps un- suitable for standard polypectomy显示文摘 | Repici A Conio M De Angelis C | 2007 | Am J Gastroenterol2007，102，8： | 1 |
| 9 | JNK pathway as therapeutic target to prevent degeneration in the central nervous system显示文摘 | Repici M Borsello T | 2006 | Adv Exp Med Biol2006，588，： | 1 |
| 10 | First data on the palliative treatment of patients with malignant gastric outlet obstruction using the WallFlex enteral stent:a retrospective multicenter study显示文摘 | Hooft J Mutignani M Repici A | 2007 | Endoscopy2007，39，： | 1 |
| 11 | Early and late outcomes of patients with obstructing coloreetal cancer treated by stenting and elective surgery: a comparison with emergency surgery and patients operated without obstructive symptoms显示文摘 | Repici A Conio M Caronna S | 2004 | Gastrointest Endose2004，59，： | 1 |
| 12 | Temporary placement of an expandable polyester silicone-covered stent for treatment of refractory benign esophageal strictures显示文摘 | Repici A Conio M De Angelis C | 2004 | Gastrointest Endosc2004，60，4： | 1 |
| 13 | Molecular mechanisms of neuronal death in the dorsal lateral geniculate nucleus following visual cortical lesions 显示文摘 | REPICI M ATZORI C MIGHELI A | 2003 | Neuroscience2003，117，4： | 1 |
| 14 | Temporary placement of an expandable ployester silicone-covered stent for treatment of refractory benign esophageal stictures显示文摘 | Repici A Conic M De Angelis C | 2004 | Gastrointest Endosc2004，60，4： | 1 |
| 15 | Temporary, placement of all expandable polyester silicone-covered stent for treatment of refractory benign esophageal strictures 显示文摘 | Repici A Conio M De Angelis C ct al | 2004 | Gastmintest Endosc2004，60，： | 1 |
| 16 | Time-course of C- Jun N - terminal kinase activation after cerebral ischemia and effect of D-JNKII on c-jun and caspase-3 activation显示文摘 | Repici M Ceneeno C Tomasi S | 2007 | Neuroscience2007，150，1： | 1 |
| 17 | Early and late outcome of patients with obstructing colorectal cancer treated by stenting and elective surgery:a comparison with emergency surgery and patients operated without obstructive symptoms显示文摘 | Repici A Conio M Caronna S | 2004 | Gastrointest Endosc2004，59，： | 1 |
| 18 | Cap-assisted endoscopic mucosal resection for colorectal polyps显示文摘 | Conio M Blanchi S Repici A | 2010 | Dis Colon Rectum2010，53，6： | 1 |
| 19 | A randomized prospective comparison of self-expandable plastic stents and partially covered self-expandable metal stents in the palliation of malignant esoph-ageal dysphasia显示文摘 | Conio M Repici A Battaglia G | 2007 | Am J Gastroenterol2007，102，12： | 1 |
| 20 | C-Jun N-terminal kinase- binding domain-dependent phosphnrylation of mitogen-activated protein kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and ex- traeellularsignal regulated kinase pathways in cortical neurons 显示文摘 | Repici M Mare L Cdombo A | 2009 | Neuroscienee2009，159，1： | 1 |
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