| 1 | Pathophysiological mechanisms and therapeutic approaches in obstructive sleep apnea syndrome显示文摘Obstructive sleep apnea syndrome(OSAS)is a common breathing disorder in sleep in which the airways narrow or collapse during sleep,causing obstructive sleep apnea.The prevalence of OSAS continues to rise worldwide,particularly in middle-aged and elderly individuals.The mechanism of upper airway collapse is incompletely understood but is associated with several factors,including obesity,craniofacial changes,altered muscle function in the upper airway,pharyngeal neuropathy,and fluid shifts to the neck.The main characteristics of OSAS are recurrent pauses in respiration,which lead to intermittent hypoxia(IH)and hypercapnia,accompanied by blood oxygen desaturation and arousal during sleep,which sharply increases the risk of several diseases.This paper first briefly describes the epidemiology,incidence,and pathophysiological mechanisms of OSAS.Next,the alterations in relevant signaling pathways induced by IH are systematically reviewed and discussed.For example,IH can induce gut microbiota(GM)dysbiosis,impair the intestinal barrier,and alter intestinal metabolites.These mechanisms ultimately lead to secondary oxidative stress,systemic inflammation,and sympathetic activation.We then summarize the effects of IH on disease pathogenesis,including cardiocerebrovascular disorders,neurological disorders,metabolic diseases,cancer,reproductive disorders,and COVID-19.Finally,different therapeutic strategies for OSAS caused by different causes are proposed.Multidisciplinary approaches and shared decision-making are necessary for the successful treatment of OSAS in the future,but more randomized controlled trials are needed for further evaluation to define what treatments are best for specific OSAS patients. | Renjun Lv Xueying Liu Yue Zhang Na Dong Xiao Wang Yao He Hongmei Yue Qingqing Yin | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 8 |
| 3 | Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila显示文摘Neuroligins (Nlgs ) 是在触处开发和功能起必要作用的 transmembrane 房间粘附分子。在 neuroligin 基因的基因变化与象孤独性那样的一些 neurodevelopmental 混乱被连接了。这些变异的 Nlgs 主要在 endoplasmic 蜂窝胃被保留(嗯) 。然而,位于正常 Nlg 成熟和 trafficking 下面的机制仍然保持大部分未知。这里,我们发现那果蝇 neuroligin (DNlg2 ) 2 在整个发展阶段在许多果蝇纸巾在 ER 经历解朊的劈开。包含 Y642T698 的一个区域为这个过程被要求。不成熟的非劈得开的 DNlg2 在 ER 被保留并且非功能。DNlg2 的 C 终端碎片而不是全身或非劈得开的 DNlg2 能救 dnlg2 删除导致的神经与肌的连接缺点和 GluRIIB 减小。有趣地,在 DNlg2 的联系孤独性的 R598C 变化在 DNlg2 解朊的过程导致类似的显著缺点,揭示在孤独性致病的不适当的 Nlg 劈开的一个潜在的角色并且嗯出口。一起,我们的调查结果揭开在 ER 经由解朊的劈开控制 DNlg2 成熟和 trafficking 的特定的机制,建议 Nlgs 的使不安的解朊的劈开多半贡献孤独性混乱。 | Renjun Tu Jinjun Qian Menglong Rui Nana Tao Mingkuan Sun Yan Zhuang Huihui Lv Junhai Han Moyi Li Wei Xie | 2017 | Journal of Molecular Cell Biology2017，9，3： | 0 |
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