2篇
您的检索式：作者名="Renata Pyzik"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Advanced Glycation End Products in Foods and a Practical Guide to Their Reduction in the Diet显示文摘 | Jaime Uribarri Sandra Woodruff Susan Goodman Weijing Cai Xue Chen Renata Pyzik Angie Yong Gary E. Striker Helen Vlassara | 2010 | Journal of the American Dietetic Association2010，，6： | 2 |
| 2 | Quantification of uric acid in vasculature of patients with gout using dual-energy computed tomography显示文摘BACKGROUNDGout, caused by hyperuricemia and subsequent deposition of aggregatedmonosodium urate crystals (MSU) in the joints or extra-articular regions, is themost common inflammatory arthritis. There is increasing evidence that gout is anindependent risk factor for hypertension, cardiovascular disease progression andmortality.AIMTo evaluate if dual energy computed tomography (DECT) could identify MSUwithin vessel walls of gout patients, and if MSU deposits within the vasculaturediffered between patients with gout and controls. This study may help elucidatewhy individuals with gout have increased risk for cardiovascular disease.METHODS31 gout patients and 18 controls underwent DECT scans of the chest andabdomen. A material decomposition algorithm was used to distinguish regions ofMSU (coded green), and calcifications (coded purple) from soft tissue (uncoded). Volume of green regions was calculated using a semi-automated volumeassessment program. Between-group differences were analyzed using Mann-Whitney U exact test and nonparametric rank regression.RESULTSGout patients had significantly higher volume of MSU within the aorta comparedto controls [Median (Min-Max) of 43.9 (0-1113.5) vs 2.9 (0-219.4), P = 0.01].Number of deposits was higher in gout patients compared to controls [Median(Min-Max) of 20 (0-739) vs 1.5 (0-104), P = 0.008]. However, the difference wasinsignificant after adjustment for age, gender, history of cardiovascular diseaseand diabetes. Increased age was positively associated with total urate volume (rs =0.64;95% confidence interval: 0.43-0.78).CONCLUSIONThis pilot study showed that DECT can quantify vascular urate deposits withvariation across groups, with gout patients possibly having higher deposition.This relationship disappeared when adjusted for age, and there was a positiverelationship between age and MSU deposition. While this study does not provethat green coded regions are truly MSU deposition, it corroborates recent studiesthat show the presence of vascular deposition. | Sharon Hannah Barazani Wei-Wei Chi Renata Pyzik Helena Chang Adam Jacobi Tom O’Donnell Zahi A Fayad Yousaf Ali Venkatesh Mani | 2020 | World Journal of Radiology2020，12，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员