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| 1 | Significance of postoperative follow-up of patients with metastatic colorectal cancer using circulating tumor DNA显示文摘BACKGROUND One of the most notable applications for circulating tumor DNA(ctDNA)detection in peripheral blood of patients with metastatic colorectal cancer(mCRC)is a long-term postoperative follow-up.Sometimes referred to as a“liquid(re)biopsy”it is a minimally invasive procedure and can be performed repeatedly at relatively short intervals(months or even weeks).The presence of the disease and the actual extent of the tumor burden(tumor mass)within the patient’s body can be monitored.This is of particular importance,especially when evaluating radicality of surgical treatment as well as for early detection of disease progression or recurrence.AIM To confirm the radicality of surgery using ctDNA and compare available methods for detection of recurrence in metastatic colorectal cancer.METHODSA total of 47 patients with detected ctDNA and indications for resection of mCRC were enrolled in the multicenter study involving three surgical centers.Standard postoperative follow-ups using imaging techniques and the determination of tumor markers were supplemented by ctDNA sampling.In addition to the baseline ctDNA testing prior to surgery,a postoperative observation was conducted by evaluating ctDNA presence up to a week after surgery and subsequently at approximately three-month intervals.The presence of ctDNA was correlated with radicality of surgical treatment and the actual clinical status of the patient.RESULTS Among the monitored patients,the R0(curative)resection correlated with postoperative ctDNA negativity in 26 out of 28 cases of surgical procedures(26/28,93%).In the remaining cases of R0 surgeries that displayed ctDNA,both patients were diagnosed with a recurrence of the disease after 6 months.In 7 patients who underwent an R1 resection,4 ctDNA positivities(4/7,57%)were detected after surgery and associated with the confirmation of early disease recurrence(after 3 to 7 months).All 15 patients(15/15,100%)undergoing R2 resection remained constantly ctDNA positive during the entire follow-up period.In 22 cases of recurrence,ctDNA positivity was detected 22 times(22/22,100%)compared to 16 positives(16/22,73%)by imaging methods and 15 cases(15/22,68%)of elevated tumor markers.CONCLUSION ctDNA detection in patients with mCRC is a viable tool for early detection of disease recurrence as well as for confirmation of the radicality of surgical treatment. | Lucie Benešová Tereza Hálková Renata Ptáčková Anastasiya Semyakina Kateřina Menclová JiříPudil Miroslav Ryska Miroslav Levý JaromírŠimša Filip Pazdírek JiříHoch Milan Blaha Marek Minárik | 2019 | World Journal of Gastroenterology2019，25，48： | 3 |
| 2 | Stability of roadways in coalmines alias rock mechanics in practice显示文摘This paper describes the procedures for design of supports and stabilization measures in the roadways.The procedures are based on the system developed in Ostrava-Karvina coal basin in Czech Republic.The calculation of load bearing capacity of roadway supports contains the period of roadway construction and mining in the vicinities,based on the size of the natural rock arch.The loading of supports during mining comes from a stress wave in the rock mass in the forefront of coalface and the caving area of mined-out panel.The input data for the calculation method are deduced according to in-situ measurements of convergence and displacement in the roadways. | Richard nupárek Petr Koneny | 2010 | Journal of Rock Mechanics and Geotechnical Engineering2010，2，3： | 2 |
| 3 | Microstructure,Properties and Wear Behaviors of (Ni_3Al)_p Reinforced Cu Matrix Composites显示文摘Pure copper and its composites reinforced with Ni 3 Al particles were produced by powder metallurgy(PM).Ni 3 Al powders were produced by mechanical ball milling from vacuum arc melted compounds.The Ni 3 Al powders were characterized by X-ray diffraction(XRD).The microscopy examinations revealed that the Ni 3 Al particles were distributed uniformly in the matrix.The effects of the particle fraction on the density,electrical conductivity,strength and dry sliding wear resistance of composite were investigated.It was found that the density and electrical conductivity of the composites decrease while the compression yield strength and wear resistance of composites increase with an increase in the particle fraction.The dry sliding wear tests were performed with pin-on-disk geometry.After sliding wear tests,the worn surfaces were examined by scanning electron microscopy(SEM) equipped with an energy dispersive X-ray spectrometer(EDS).Results have shown that the wear mechanism is oxidative and adhesive. | Ibrahim elikyrek Nese .Krpe Tugba ler Remzi Grler | 2011 | Journal of Materials Science & Technology2011，27，10： | 2 |
| 4 | Photostability of Polyurethame Elastomer Based on Two Types of Diisocyanates显示文摘 | | 1995 | J Elastomersplastics1995，26，14： | 1 |
| 5 | Identification and mapping of submerged plants in a shallow lake using quick bird satellite data显示文摘 | Dogan O K Akyu rek Z Bek lioglu M | 2008 | Environmental Management2008，，： | 1 |
| 6 | 查看详情显示文摘 | (O)zyürek Z Komber H Gramm S Schmaljohann D Müller A H E Voit B | | 0，，10： | 1 |
| 7 | Adsorption of copper, cadmium, lead and zinc onto a synthetic manganese oxide显示文摘 | PUPPA L D KOM~REK M BORDAS F | 2013 | Journal of Colloid and Interface Science2013，，399： | 1 |
| 8 | G Protein-COu-pied receptor agonists activate endogenous phospholipase Cepsi-lon and phospholipase Cβ3 in a temporally distinct manner显示文摘 | Kaproth-Josline KA Reks SE | 2006 | J Biol Chem2006，281，5： | 1 |
| 9 | Comparison of animal infectivity and nucleic acid staining for assessment of Cryptosporidium parvum viability in water显示文摘 | Neumann N F Gyūrek L L Gammie L | 2000 | Appl Environ Microbiol2000，66，： | 1 |
| 10 | Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells显示文摘 | Ferreira-Mattins J Og 6 rek B Cappetta D | 2012 | Circ Res2012，，110： | 1 |
| 11 | Primary hemophagocytic lymphohistiocytosis in Turkish children显示文摘 | Gürgey A Gogüos S Ozyürek E | 2003 | Pediatr Hematol Oncol2003，20，： | 1 |
| 12 | Diagnostic and prognostic significance of image cytometric DNA ploidy measurement in cytological samples of cervical squamous intraepithelial lesions 显示文摘 | DEMIREL D AKY REK N RAMZY I | 2013 | Cytopathology : Official Journal of the British Society for Clinical Cytology2013，24，2： | 1 |
| 13 | Smooth muscle cell migration into intima and adventitia during development of transplant vasculopathy显示文摘 | Akyürek LM Paul LC Fura K | 1996 | Transplantation1996，62，5： | 1 |
| 14 | Behaviour of Li isotopes during continental weathering:the Bidar laterite profile,India显示文摘 | Basak K1sakürek Widdowson M James R H | 2004 | Chemical Geology2004，212，： | 1 |
| 15 | Phospholipase Cε: a novel Ras effector显示文摘 | Kelly G G Reks S E Ondrako J M | 2001 | EMBO2001，4，20： | 1 |
| 16 | Frequency of vaginal candida colonization and relationship between metabolic parameters in children with type 1 diabetes mellitus显示文摘 | Atabek ME Akyürek N Eklioglu BS | 2013 | Pediatr Adolesc Gynecol2013，26，5： | 1 |
| 17 | Filamins in cell signaling, transcription and organ development显示文摘 | Alex-Xianghua Zhou John H. Hartwig Levent M. Akyürek | 2009 | Trends in Cell Biology2009，，2： | 1 |
| 18 | Direct closure of radial forearm free- flap donor sites by double-opposing rhomboid transposition flaps: case report显示文摘 | Aky~rek M Safak T | 2002 | J Reconstr Microsurg2002，18，1： | 1 |
| 19 | ET-AAS determination of aluminium in dialysis concentrates after continuous flow solvent extraction显示文摘 | J. Komárek R. ?ervenka T. R??i?ka V. Kubáň | 2007 | Journal of Pharmaceutical and Biomedical Analysis2007，，3： | 1 |
| 20 | Noval total antioxidant capacity index for dietary polyphenols and Vitamins C and E,using their cupric ion reducing capability in the presence of Neocuproine:CUPRAC method显示文摘 | Apark R GülüK zyürek M | 2004 | J Agric Food Chem2004，52，26： | 1 |
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