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| 1 | Relevance of MUC1 mucin variable number of tandem repeats polymorphism in H pylori adhesion to gastric epithelial cells显示文摘AIM:To evaluate the influence of MUC1 mucin variable number of tandem repeats (VNTR) variability on H pylori adhesion to gastric cells. METHODS: Enzyme linked immunosorbent assay (ELISA)-based adhesion assays were performed to measure the adhesion of different H pylori strains (HP26695 and HPTx30a) to gastric carcinoma cell lines (GP202 and MKN45) and GP202 clones expressing recombinant MUC1 with different VNTR lengths. RESULTS: Evaluation of adhesion results shows that H pylori pathogenic strain HP26695 has a significantly higher (P < 0.05) adhesion to all the cell lines and clones tested, when compared to the non-pathogenic strain HPTx30a. Bacteria showed a significantly higher (P < 0.05) adhesion to the GP202 cell line, when compared to the MKN45 cell line. Furthermore, both strains showed a significantly higher (P < 0.05) adhesion to GP202 clones with larger MUC1 VNTR domains. CONCLUSION: This work shows that MUC1 mucin variability conditions H pylori binding to gastric cells. The extent of bacterial adhesion depends on the size of theMUC1 VNTR domain. The adhesion is further dependent on bacterial pathogenicity and the gastric cell line. MUC1 mucin variability may contribute to determine H pylori colonization of the gastric mucosa. | Natália R Costa Nuno Mendes Nuno T Marcos Celso A Reis Thomas Caffrey Michael A Hollingsworth Filipe Santos-Silva | 2008 | World Journal of Gastroenterology2008，14，9： | 4 |
| 2 | Innate antiviral responses by means of TLRT-mediated recognition of single-stranded RNA显示文摘 | Diebold S S Kaisho T Hemmi H Akira S Reis e Sousa C | 2004 | Science2004，303，： | 1 |
| 3 | Tambourgi, synthesis and characterization of a starch modified hydrogel as potential carrier for drug delivery system显示文摘 | REIS A V GUIHEME M R MOIA T A | 2008 | Journal of Polymer Science Part A: Polymer Chemistry2008，46，7： | 1 |
| 4 | Recovery of phenol from aqueous solutions using liquid membranes with cyanex 923显示文摘 | Reis M T A De freitas O M Ismael M R C | 2007 | J Membrane Sci2007，305，1： | 1 |
| 5 | RECK:A novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling 显示文摘 | Makoto N Junseo O Rei T | 2003 | Cancer Metastasis Res2003，22，23： | 1 |
| 6 | Sulfate reduction in acidogenic phase anaerobic-digestion 显示文摘 | REIS M A M GONCALVES L M D CARRONDO M J T | 1988 | Water Science and Technology1988，20，1112： | 1 |
| 7 | Serum concentrations of antidepressant drugs in a naturalistic setting: compilation based on a large therapeutic drug monitoring database显示文摘 | REIS M AAMO T SPIGSET O | 2009 | Ther Drug Monit2009，31，1： | 1 |
| 8 | A comparative investigation of FK506 and cyclosporin A in murine corneal transplantation显示文摘 | Reis A Reinhard T Sundmacher R | | 0，，10： | 1 |
| 9 | Validation of a matrix solid phase dispersion (MSPD) technique for determination of pesticides in lyophilized eggs of the chicken Gallus gallus domesticus显示文摘 | dos Reis Souza M K Moreira C O de Lima T G | 2013 | Microchem J2013，110，： | 1 |
| 10 | Chapter 11 Biomonitors in use: lichens and metal air pollution显示文摘 | WOLTERBEEK H T GARTY J REIS M A | 2003 | Trace Metals and Other Contaminants in the Environment2003，6，： | 1 |
| 11 | Daily well - being: The role of autonomy, competence, and re- latedness 显示文摘 | REIS H T SHELDON K M GABLE S L | 2000 | Personality and Social Psychology Bulletin2000，26，4： | 1 |
| 12 | Prospective and randomized comparison of electrical stimulation of the posterior tibial nerve versusoxybutynin versus their combination for treatment of women with overactive bladder syndrome显示文摘 | Souto S C Reis L O Palma T | 2014 | World J Urol2014，32，1： | 1 |
| 13 | Modelling of zinc extraction from sulphate solutions with bis (2-ethylhexyl) thiophosphoric acid by emulsion liquid membranes显示文摘 | Reis M T A Carvalho J M R | 2004 | Journal of Membrane Science2004，237，： | 1 |
| 14 | Impaired immune respon- ses and prolonged allograft survival in Slyl mutant mice 显示文摘 | Beer S Scheikl T Reis B | 2005 | Mol Cell Biol2005，25，21： | 1 |
| 15 | Depression in heart failure a meta-analytic review of prevalence,intervention effects,and association with clinical outcomes显示文摘 | Rutledge T Reis VA Linke SE | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 16 | Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes 显示文摘 | Rutledge T Reis VA Linke SE | 2006 | J Am Coll Cardiol2006，48，8： | 1 |
| 17 | Effect of early luteolysis in progesteronebased time AI protocols in Bos indicus,Bos indicus×Bos taurus,and Bos taurus heifers显示文摘 | CARVALHO J B P CARVALHO N A T REIS E L | | 0，，02： | 1 |
| 18 | Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes 显示文摘 | Rutledge T Reis VA Linke SE | 2006 | J Am Coil Cardiol2006，48，8： | 1 |
| 19 | Superabsorbent hydrogel based on modified polysaccharide for removal of Pb^2+ and Cu^2+ from water with excellent performance 显示文摘 | Guilherme M R Reis A V Paulino A T | 2007 | Journal of Applied Polymer Science2007，105，： | 1 |
| 20 | Chemical Dura hility and Structure of Zinc-Iron Phosphate Glasses显示文摘 | Reis S T Karabulut M Day D E | 2001 | J Non-Cryst Solids2001，292，13： | 1 |
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