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| 1 | Woofer–tweeter adaptive optical structured illumination microscopy显示文摘A woofer–tweeter adaptive optical structured illumination microscope(AOSIM) is presented. By combining a low-spatial-frequency large-stroke deformable mirror(woofer) with a high-spatial-frequency low-stroke deformable mirror(tweeter), we are able to remove both large-amplitude and high-order aberrations. In addition, using the structured illumination method, as compared to widefield microscopy, the AOSIM can accomplish highresolution imaging and possesses better sectioning capability. The AOSIM was tested by correcting a large aberration from a trial lens in the conjugate plane of the microscope objective aperture. The experimental results show that the AOSIM has a point spread function with an FWHM that is 140 nm wide(using a water immersion objective lens with NA=1.1) after correcting a large aberration(5.9 μm peak-to-valley wavefront error with 2.05 μm RMS aberration). After structured light illumination is applied, the results show that we are able to resolve two beads that are separated by 145 nm, 1.62× below the diffraction limit of 235 nm. Furthermore, we demonstrate the application of the AOSIM in the field of bioimaging. The sample under investigation was a green-fluorescentprotein-labeled Drosophila embryo. The aberrations from the refractive index mismatch between the microscope objective, the immersion fluid, the cover slip, and the sample itself are well corrected. Using AOSIM we were able to increase the SNR for our Drosophila embryo sample by 5×. | QINGGELE LI MARC REINIG DAICH KAMIYAMA BO HUANG XIAODONG TAO ALEX BARDALES JOEL KUBBY | 2017 | Photonics Research2017，5，4： | 3 |
| 2 | Thickness dependence of optical scattering and surface roughness in microcrystalline silicon 显示文摘 | BRUGGEMANN R REINIG P HOLLING M | 2003 | Thin Solid Films2003，427，： | 1 |
| 3 | Deletion of the re- ceptor for advanced glycation end products reduces glomer- ulosclerosis and preserves renal function in the diabetic OVE26 mouse 显示文摘 | Reiniger N Lau K Mccalla D | 2010 | Diabetes2010，59，： | 1 |
| 4 | Highly 100-oriented Growth of Polycrystalline Silicon Films on Glass by Pulsed Magnetron Sputtering显示文摘 | REINIG P SELLE B FENSKE F | 2002 | Journal of Vacuum Science Technology2002，20，6： | 1 |
| 5 | Five-year fol-low-up of macular hole surgery with peeling of the internal lim-iting membrane:update of a prospective study 显示文摘 | Haritoglou C Reiniger IW Schaumberger M | 2006 | Retina2006，26，： | 1 |
| 6 | Adrenal masses differentiated by MR显示文摘 | Reinig JW Doppman JL Dwyer AJ | 1986 | Radiology1986，158，1： | 1 |
| 7 | Left ventricular en- docardial pacing: a transarterial approach 显示文摘 | Reinig M White M Levine M | 2007 | Pacing Clin Electrophysiol2007，30，12： | 1 |
| 8 | Synthesis of Novel Rhenium and Technetium N2 O2 Schiff Base Complexes 显示文摘 | Reinig K M Rotsch D A Radford L L | 2014 | Nucl Med Biol2014，41，7： | 1 |
| 9 | Liver metastases detection: Comparative sensitivities of MR imaging and CT scanning显示文摘 | Dwyer AJ Miller DL | 1987 | Radiology1987，162，： | 1 |
| 10 | More real-time visual and haptic interaction with anatomical data显示文摘 | Reinig KD Spitzer VM Pelster HL | 1997 | Stud Health Technol Inform1997，39，： | 1 |
| 11 | Liver metastasis detection:comparative sensitivities of MR imaging and CT scanning显示文摘 | Reinig JW Dwyer AJ Miller DL | 1987 | Radiology1987，162，11： | 1 |
| 12 | Evalua- tion of the internal limiting membrane after conventional peeling during macular hole surgery 显示文摘 | Haritoglou C Schumann R Reiniger I | 2006 | Retina2006，26，： | 1 |
| 13 | Left ventricular en- docardial pacing: a transarterial approach显示文摘 | REINIG M WHITE M LEVINE M | 2007 | Pacing Clin Elec- trophysiol2007，30，12： | 1 |
| 14 | Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse显示文摘 | Reiniger N Lau K Mccalla D | 2010 | Diabetes2010，59，8： | 1 |
| 15 | The cut-off levels of CD23 expression in the differential diagnosis of MCL and CLL显示文摘 | BARNA G REINIGER L TATRAI P | 2008 | Hematol Oncol2008，26，： | 1 |
| 16 | Liver metastases detection: comparative sensitivities of MR imaging and CT scanning 显示文摘 | Reinig JW Dwyer AF Miller DL | 2003 | Radiology2003，162，1： | 1 |
| 17 | Five-year follow-up of macular hole surgery with peeling of the internal limiting membrane:update of aprospective study 显示文摘 | Haritoglou C Reiniger IW Sehaumberge M | 2006 | Retina2006，25，： | 1 |
| 18 | More real-time visual and haptic interaction with anatomical data 显示文摘 | Reinig KD Spitzer VM Pelster HL | 1997 | Stud Health Techno Info1997，39，： | 1 |
| 19 | Real-time visually and haptically accurate surgical simulation 显示文摘 | Reinig KD Rush CG Pelster HL etal | 1996 | Stud Health Technol Inform1996，29，： | 1 |
| 20 | On the meas- urement of ideation quality显示文摘 | REINIG B BRIGGS R NUNAMAKER Jr F | 2007 | Journal of Management Infor- mation Systems2007，23，4： | 1 |
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