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| 1 | Vitamin D improves inflammatory bowel disease outcomes:Basic science and clinical review显示文摘Vitamin D deficiency is commonly diagnosed among patients with inflammatory bowel disease(IBD).Patients with IBD are at risk of low bone density and increased fractures due to low vitamin D levels,long standing disease,and frequent steroid exposures;as a result,it is well established that vitamin D supplementation in this population is important.There is increasing support for the role of vitamin D in strengthening the innate immune system by acting as an immunomodulator and reducing inflammation in experimental and human IBD.The active form of vitamin D,1,25(OH)D3,acts on T cells to promote T helper(Th)2/regulatory T responses over Th1/Th17 responses;suppresses dendritic cell inflammatory activity;induces antibacterial activity;and regulates cytokine production in favor of an antiinflammatory response.Murine and human IBD studies support a therapeutic role of vitamin D in IBD.Risk factors for vitamin D deficiency in this population include decreased sunlight exposure,disease duration,smoking,and genetics.Vitamin D normalization is associated with reduced risk of relapse,reduced risk of IBD-related surgeries,and improvement in quality of life.Vitamin D is an inexpensive supplement which has been shown to improve IBD outcomes.However,further research is required to determine optimal serum vitamin D levels which will achieve beneficial immune effects,and stronger evidence is needed to support the role of vitamin D in inducing disease response and remission,as well as maintaining this improvement in patients’disease states. | Krista M Reich Richard N Fedorak Karen Madsen Karen I Kroeker | 2014 | World Journal of Gastroenterology2014，20，17： | 34 |
| 2 | Distance management of inflammatory bowel disease:Systematic review and meta-analysis显示文摘AIM:To review the effectiveness of distance management methods in the management of adult inflammatory bowel disease(IBD)patients.METHODS:A systematic review and meta-analysis of randomized controlled trials comparing distance management and standard clinic follow-up in the management of adult IBD patients.Distance management intervention was defined as any remote management method in which there is a patient self-management component whereby the patient interacts remotely via a self-guided management program,electronic interface,or self-directs open access to clinic follow up.The search strategy included electronic databases(Medline,PubMed,CINAHL,The Cochrane Central Register of Controlled Trials,EMBASE,KTPlus,Web of Science,and SCOPUS),conference proceedings,and internet search for web publications.The primary outcome was the mean difference in quality of life,and the secondary outcomes included mean difference in relapse rate,clinic visit rate,and hospital admission rate.Study selection,data extraction,and risk of bias assessment were completed by two independent reviewers.RESULTS:The search strategy identified a total of4061 articles,but only 6 randomized controlled trials met the inclusion and exclusion criteria for the systematic review and meta-analysis.Three trials involved telemanagement,and three trials involved directed patient self-management and open access clinics.The total sample size was 1463 patients.There was a trend towards improved quality of life in distance management patients with an end IBDQ quality of life score being 7.28(95%CI:-3.25-17.81)points higher than standard clinic follow-up.There was a significant decrease in the clinic visit rate among distance management patients mean difference-1.08(95%CI:-1.60--0.55),but no significant change in relapse rate or hospital admission rate.CONCLUSION:Distance management of IBD significantly decreases clinic visit utilization,but does not significantly affect relapse rates or hospital admission rates. | Vivian W Huang Krista M Reich Richard N Fedorak | 2014 | World Journal of Gastroenterology2014，20，3： | 9 |
| 3 | Principal components analysis corrects for stratification in genome-wide association studies 显示文摘 | Price A L Patterson N J Plenge R M Weinblatt M E Sbadick N A Reich D | 2006 | Nature Genetics2006，38，8： | 1 |
| 4 | Cardiospheres reverse adverse remodeling in chronic rat myocardial infarction: roles of soluble endoglin and Tgf-β signaling显示文摘 | Eleni Tseliou Heidi Reich Geoffrey Couto John Terrovitis Baiming Sun Weixin Liu Eduardo Marbán | 2014 | Basic Research in Cardiology2014，，6： | 1 |
| 5 | Online and offline social networks:Use of social networking sites by emerging adults显示文摘 | Subrahmanyam K Reich S M Waechter N | | 0，，06： | 1 |
| 6 | Survival probability ofzirconia-based fixed dental prostheses up to 5 yr:a systematicreview of the literature显示文摘 | SchleyJS Heussen N Reich S | 2010 | Eur J Oral Sci2010，118，： | 1 |
| 7 | High proliferation rate characterizes the site of axis formation in the avian blastula-stage embryo显示文摘 | ZAHAVI N REICH V KHANER O | 1998 | Int J Dev Biol1998，42，1： | 1 |
| 8 | Efficient Transformation of Alfalfa Pro- toplasts by the Intranuelear Mieroinjeetion of Ti-plasmids 显示文摘 | Reich T J Lyer V N Mikib L | 1986 | Bio Tehnology1986，，4： | 1 |
| 9 | Self-Assembly of DNA Arrays into Multilayer Stacks显示文摘 | Koyfman A Y Magonov S N Reich N O | 2009 | Langmuir2009，25，2： | 1 |
| 10 | Discrimination of DS M-Ⅳ and latent class attentiorr deficit/hyperactivity disorder subtypes by educational and cognitive performance in a populatiorr based sample of child and adolescent twins 显示文摘 | Todd RD Sitdhiraksa N Reich W | 2002 | J Am Acad Child Adolesc Psychiatry2002，41，7： | 1 |
| 11 | Cerebral metabolic suppression during hypothermic circulatory arrest in humans显示文摘 | Zhang N Reich DL | 1999 | Ann Thorac Surg1999，67，6： | 1 |
| 12 | Efficient moment-based inference of admixture parameters and sources of gene flow显示文摘 | Lipson M Loh PR Levin A Reich D Patterson N Berger B | | 0，，： | 1 |
| 13 | Xylem flow and its driving forces in a tropical liana: concomitant flow-sensitive NMR imaging and pressure probe measurements显示文摘 | Wistuba N Reich R Wagner H J | 2000 | Plant Biology2000，2，： | 1 |
| 14 | Loss of corneal Langerhans cells during storage in organ culture edium, optisol and McCarey Kaufman medium 显示文摘 | Ardjomand N Berghold A Reich ME | 1998 | Eye1998，12，1： | 1 |
| 15 | Precipitation and wor k hardening in hig h strength AlZnMg(Cu, Zr) alloys 显示文摘 | Kovacs Zs Reich L | 1996 | Materials Science Forum1996，，： | 1 |
| 16 | Cerebral metabolic suppression daring hypothermic circulatory arrest in humans显示文摘 | McCullough JN Zhang N Reich DL | 1999 | Ann Thorac Surg1999，67，6： | 1 |
| 17 | Precipitation in Al- Zn-Mg-(Cu, Zr) alloys 显示文摘 | Kovacs Zs Reich L | 1997 | Z Metallkd1997，88，8： | 1 |
| 18 | Ethical Challenges in Pain Man- agement Post-Surgery显示文摘 | Reich N Ahmadi F Mohamadi E | 2009 | Nurs Ethics2009，16，2： | 1 |
| 19 | Decision networks for integrating the behaviors of virtual agents and avatars 显示文摘 | T Trias S Chopin B Reich M Moore N Badler B Webber C Geib | 1996 | IEEE VRAIS1996，，： | 1 |
| 20 | Precipitation and work harding in high strength AlZnMg(Cu,Zr) alloys显示文摘 | Chinh N Q Kovacs Zs Reich L | 1996 | Materials Science Forum1996，，： | 1 |
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