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| 1 | Expression Patterns of Inducible Cre Recombinase Driven by Differential Astrocyte-Specific Promoters in Transgenic Mouse Lines显示文摘Astrocytes are the most abundant cell type in the central nervous system(CNS).They provide trophic support for neurons,modulate synaptic transmission and plasticity,and contribute to neuronal dysfunction.Many transgenic mouse lines have been generated to obtain astrocyte-specific expression of inducible Cre recombinase for functional studies;however,the expression patterns of inducible Cre recombinase in these lines have not been systematically characterized.We generated a new astrocyte-specific Aldh1 l1-CreER^(T2)knock-in mouse line and compared the expression pattern of Cre recombinase between this and five widely-used transgenic lines(hGfap-CreER^(T2)from The Jackson Laboratory and The Mutant Mouse Resource and Research Center,Glast-CreER^(T2),Cx30-CreER^(T2),and Fgfr3-iCreER^(T2))by crossing with Ai14 mice,which express tdTomato fluorescence following Cre-mediated recombination.In adult Aldh1 l1-CreER^(T2):Ai 14 transgenic mice,tdTomato was detected throughout the CNS,and five novel morphologicallydefined types of astrocyte were described.Among the six evaluated lines,the specificity of Cre-mediated recombination was highest when driven by Aldh1 l1 and lowest when driven by hGfap;in the latter mice,co-staining between tdTomato and NeuN was observed in the hippocampus and cortex.Notably,evident leakage was noted in Fgfr3-iCreER^(T2)mice,and the expression level of tdTomato was low in the thalamus when Cre recombinase expression was driven by Glast and in the capsular part of the central amygdaloid nucleus when driven by Cx30.Furthermore,tdTomato was clearly expressed in peripheral organs in four of the lines.Our results emphasize that the astrocyte-specific CreER^(T2)transgenic lines used in functional studies should be carefully selected. | Neng-Yuan Hu Ya-Ting Chen Qian Wang Wei Jie Yi-Si Liu Qiang-Long You Ze-Lin Li Xiao-Wen Li Sophie Reibel Frank W.Pfrieger Jian-Ming Yang Tian-Ming Gao | 2020 | Neuroscience Bulletin2020，36，5： | 3 |
| 2 | Endogenous control of hippocampal epilep togenesisa molecular cascade involving brain derived neuro trophic factor and neuro peptide Y显示文摘 | Reibel S L armet Y Carnahan J | 2000 | Epilepsia2000，41，： | 1 |
| 3 | Liposarcoma arising in the pharynx nine years after fibrolipoma excision显示文摘 | Reibel JF Greene WM | 1995 | Otolaryngol Head Neck Surg1995，112，4： | 1 |
| 4 | Protective effects of brain derived neuro trophic factor on the development of hippocampal kindling in the rat显示文摘 | Larmet Y Reibel S Carnahan J | 1995 | Neurorport1995，6，14： | 1 |
| 5 | Demonstration of broadband true-time delay with optical coherent transients显示文摘 | M Tian R Reibel R Babbitt | 2001 | 0 -7803-7003-12001，2001，： | 1 |
| 6 | Orodental phenotype and genotype findings in all subtypes of hypophosphatasia显示文摘 | Reibel A Manière MC Clauss F | 2009 | Orphanet J Rare Dis2009，4，： | 1 |
| 7 | Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation显示文摘 | Reibel S Nadi S Benmaamar R | 2001 | Peptides2001，22，3： | 1 |
| 8 | Mindfulness based stress reduction is associated with improved glycemic control in type 2 diabetes mellitus : a pilot study 显示文摘 | Rosenzweig S Reibel DK Greeson JM | 2007 | Altern Ther Health Med2007，13，5： | 1 |
| 9 | Brain-derived neurotrophic factor delays hippoeampal kinding in the rat 显示文摘 | Reibel S Latmet Y | 2000 | Neuroscience2000，100，： | 1 |
| 10 | Street-weighted interpolation tech- niques for demographic count estimation in incompatible zone systems显示文摘 | Reibel M Bufalino M E | 2005 | Environment and Planning A2005，37，1： | 1 |
| 11 | Neuroprotective effects of chronic estradiol benzoate treatment on hippocampal cell loss induced by status epilepticus in the female rat显示文摘 | Reibel S Andre V Chassagnon S | | 0，，： | 1 |
| 12 | Mindfulness- based stress reduction for chronic pain conditions:variation in treatment outcomes and role of home meditation practice 显示文摘 | Rosenzweig S Greeson JM Reibel DK | 2010 | J Psychosom Res2010，68，1： | 1 |
| 13 | The atopic Patch test(APT)-α useful tool for the diagnosis of food allergy in children with atopic dermatitis显示文摘 | Niggemann B Reibel S Wahn U | 2000 | Allergy2000，55，3： | 1 |
| 14 | The Rac target NADPH oxidase p67phox interacts preferentially with Rac2 rather thanRacl显示文摘 | Dorseuil O Reibel L Bokoch GM | 1996 | JBiolChem1996，271，1： | 1 |
| 15 | Rapid antifungal susceptibility testing of fluconazole and amphotericin B by flow cytometry Using FUN-1 ? : a preliminary study 显示文摘 | Parisi-Duchene E Reibel C Grawey I | 2006 | J Meal Microbiol2006，16，3： | 1 |
| 16 | In- fluence of Phase Position on the Performance of Chem- ical Sensors Based on SAW Device Oseillators显示文摘 | Jurgen Reibel Stefan Stier Achim Voigt | 1998 | A- nal Chem1998，70，24： | 1 |
| 17 | The atopy patch test( APT)-a useful tool for the diagnosis of food allergy in children with atopic dermatitis 显示文摘 | Niggemann B Reibel S Wahn U | 2000 | Allerg2000，55，3： | 1 |
| 18 | Subjectivity in e- valuating oral epithelial dysplasia, carcinoma in situ and ini- tial carcinoma显示文摘 | Pindborg JJ Reibel J Holmstrup P | 1985 | J Oral Pathol1985，14，： | 1 |
| 19 | Demonstration of broadband true-time delay with optical coherent transients 显示文摘 | M Tian R Reibel R Babbitt | 2001 | IEEE2001，，： | 1 |
| 20 | Oral findings in patients with primary Sjogem's syndrome and oral lichen planusa preliminary study on the effects of bovine colostrum-containing oral hygiene products显示文摘 | Pedersen AM Andersen TL Reibel J | 2002 | Clin Oral Invest2002，6，： | 1 |
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