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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Migraine prevalence, disease burden, and the need for preventive therapy显示文摘 | R B. Lipton M E. Bigal M Diamond F Freitag M L. Reed W F. Stewart | 2007 | Neurology2007，，5： | 2 |
| 4 | Development of a global land cover characteristics database and IGBP DISCover from 1km AVHRR data 显示文摘 | Loveland T R Reed B C Brown J F | 2000 | International Journal of Remot Sensing2000，21，67： | 1 |
| 5 | Anonymous connections and onion routing 显示文摘 | REED M G SYVERSON P F | 1998 | IEEE Journal on Selected Areas in Communication-Special Issue on Copyright and Privacy Protection1998，16，4： | 1 |
| 6 | Statistical analysis of real - timePCR data显示文摘 | Yuan J S Reed A Chen F | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 7 | Statistical analysis of re- al-time PCR data 显示文摘 | Yuan JS Reed A Chen F | 2006 | BMC Bioinformatics2006，7，： | 1 |
| 8 | Trust and adaptation in relational contracting显示文摘 | JEFHIES F L REED R | 2000 | Academy Management Review2000，25，： | 1 |
| 9 | Effect of doping on the magnetic properties of GaMnN: Fermi level engineering显示文摘 | Reed M J Arkun F E Berkman E A | 2005 | Applied Physics Letters2005，86，10： | 1 |
| 10 | Development of a global land cover characteristics database and IGBP DISCover from 1 km AVHRR data显示文摘 | Loveland T R Reed B C Brown J F | 2000 | International Journal of Remote Sensing( in review)2000，21，7： | 1 |
| 11 | Optimum Ackerman for improved steering axle tire wear on trucks 显示文摘 | Miller G Reed R Wheeler F | 1991 | Transactions of Society of Automotive Engineers1991，2，： | 1 |
| 12 | Enhanced in vitro growth of murine fibroblast cells and preimplantation embryos cultured in medium supplemented with an amphipathic peptide显示文摘 | Reed W A White K L Enright F M | 1992 | Mol Reproduct1992，31，2： | 1 |
| 13 | Anterior spine fusion using Zielke instrumentation for adult thoracolumbar and lumbar scoliosis显示文摘 | Trammell TR Benedict F Reed D | 1991 | Spine1991，16，： | 1 |
| 14 | Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression显示文摘 | Reed JA Loganzo F Shea CR | 1995 | Cancer Res1995，55，13： | 1 |
| 15 | Natural fractures in the Barnett shale and their importance for hydraulic fracture treatments显示文摘 | Gale J F W Reed R M Holder J | 2007 | AAPG Bulletin2007，91，4： | 1 |
| 16 | Bclx1 Bax interaction after transient global ischemia显示文摘 | Antonawich F J krajewski S Reed J C | | 0，，： | 1 |
| 17 | Natural fractures in the Barnett shale and their importance for hydraulic fracture treatments显示文摘 | Julia F W G Reed R M Holder Jon | 2007 | AAPG2007，91，4： | 1 |
| 18 | Loss of expression of the P16/cyclin dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesion correlated with invasive stage of tumor progression 显示文摘 | Loganzo F | 1995 | Cancer Res1995，55，： | 1 |
| 19 | Anonymous Connections and Onion Routing显示文摘 | Reed M G Syverson P F Goldschlag D M | | 0，，： | 1 |
| 20 | Development of a global land cover characteristics database and IGBP DISCover from 1 km AVHRR data 显示文摘 | Loveland T R Reed B C Brown J F | 2002 | International Journal of Remote Sensing2002，21，67： | 1 |
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