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| 1 | Probiotic metabolites from Bacillus coagulans GanedenBC30^(TM) support maturation of antigen-presenting cells in vitro显示文摘AIM:To study the effects of probiotic metabolites on maturation stage of antigen-presenting immune cells.METHODS:Ganeden Bacillus coagulans 30(GBC30) bacterial cultures in log phase were used to isolate the secreted metabolite(MET) fraction.A second fraction was made to generate a crude cell-wall-enriched fraction,by centrifugation and lysis,followed by washing.A preparation of MET was subjected to size exclusion centrifugation,generating three fractions:< 3 kDa,3-30 kDa,and 30-200 kDa and activities were tested in comparison to crude MET and cell wall in primary cultures of human peripheral blood mononuclear cell(PBMC) as a source of antigen-presenting mononuclear phagocytes.The maturation status of mononuclear phagocytes was evaluated by staining with monoclonal antibodies towards CD14,CD16,CD80 and CD86 and analyzed by flow cytometry.RESULTS:Treatment of PBMC with MET supported maturation of mononuclear phagocytes toward both macrophage and dendritic cell phenotypes.The biological activity unique to the metabolites included a reduction of CD14+ CD16+ pro-inflammatory cells,and this property was associated with the high molecular weight metabolite fraction.Changes were also seen for the dendritic cell maturation markers CD80 and CD86.On CD14dim cells,an increase in both CD80 and CD86 expression was seen,in contrast to a selective increase in CD86 expression on CD14bright cells.The co-expression of CD80 and CD86 indicates effective antigen presentation to T cells and support of T helper cell differentiation.The selective expression of CD86 in the absence of CD80 points to a role in generating T regulatory cells.CONCLUSION:The data show that a primary mechanism of action of GBC30 metabolites involves support of more mature phenotypes of antigen-presenting cells,important for immunological decision-making. | Kathleen F Benson Kimberlee A Redman Steve G Carter David Keller Sean Farmer John R Endres Gitte S Jensen | 2012 | World Journal of Gastroenterology2012，18，16： | 8 |
| 2 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 2 |
| 3 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 4 | A new RNA-friendly fixative for the preservation of penaeid shrimp samples for virological detection using eDNA genomie probes显示文摘 | Hasson K W Hasson J Aubert H Redman R M Lightner D V | 1997 | J Virol Methods1997，66，2： | 1 |
| 5 | Activity of SUl1248, a muhitargeted inhibitor of vascular endothelial growth faclor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson MD Redman BG | 2006 | J Clin Oncol2006，24，1： | 1 |
| 6 | Competency assessment: methods for development and implementation in nursing education 显示文摘 | Redman R W Lenburg C B Hinton Walker P | 1999 | Online Journal of Issues in Nursing1999，4，2： | 1 |
| 7 | The development of synovial joints显示文摘 | Khan IM Redman SN Williams R | 2007 | Curr Top Dev Biol2007，79，： | 1 |
| 8 | Uhrastructure and morphogenesis of white spot syndrome baculovirus (WSSV) 显示文摘 | Durand S Lightner D V Redman R M | 1997 | Dis Aquat Org1997，29，： | 1 |
| 9 | Age-dependent effects of jasmonic acid treatment and wind exposure on foliar oxidase activity and insect resistance in to mato显示文摘 | Cipollini D F J R Redman A M | 1999 | Journal of Chemical Ecology1999，25，2： | 1 |
| 10 | Infectious hypodermal and hematopoietic necrosis, a newly recognized virus disease of penaeid shrimp显示文摘 | Lightner D V Redman R M Bell T A | 1983 | Invertebrate Pathology1983，42，： | 1 |
| 11 | Reduced adipose tissue oxygenation in human obesity:evidence for rarefaction,macrophage chemotaxis,and inflammation without an angiogenic response显示文摘 | Pasarica M Sereda O R Redman L M | | 0，，03： | 1 |
| 12 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 13 | Qualitative and quantitative studies on the relative virus load of tails and heads of shrimp acutely infected with WSSV显示文摘 | Durand S V Redman R M | 2003 | Aquaculture2003，216，14： | 1 |
| 14 | Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson M D Redman B G | 2006 | J CIin Oncol2006，24，1： | 1 |
| 15 | Infectious hypodermal and haematopoietic necrosis, a newly recognized virus disease of penaeid shrimp 显示文摘 | Lighter D V Redman R M Bell T A | 1983 | J Invertebr Pathol1983，42，： | 1 |
| 16 | Shrimp diseases and current diagnostic methods显示文摘 | Lightner D V Redman R M | 1998 | Aquaculture1998，164，： | 1 |
| 17 | Time of Day Variations in Driving Performance显示文摘 | Lenne M G Triggs T J Redman J R | 1997 | Accident Analysis and Prevention1997，29，4： | 1 |
| 18 | Safety of intravenous infusion of doripenem显示文摘 | REDMAN R FILE TM | 2009 | Clin Infect Dis2009，49，1： | 1 |
| 19 | The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules 显示文摘 | REDMAN R ZALAZNICK H MAZZAFERRI E L | 2006 | Thyroid2006，16，1： | 1 |
| 20 | Biochemical analysis of plant protection afforded by a nonpathogenic endophytic mutant of Col- letotrlchum magna 显示文摘 | Redman R S Freeman S Clifton D R | 1999 | Plant Physiology1999，119，2： | 1 |
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