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| 1 | Staging accuracy of esophageal cancer by endoscopic ultrasound:A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) in the staging of esophageal cancer. METHODS: Only EUS studies confirmed by surgery were selected. Articles were searched in Medline and Pubmed. Two reviewers independently searched and extracted data. Meta-analysis of the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS: Forty-nine studies (n = 2558) which met the inclusion criteria were included in this analysis. Pooled sensitivity and specificity of EUS to diagnose T1 was 81.6% (95% CI: 77.8-84.9) and 99.4% (95% CI: 99.0-99.7), respectively. To diagnose T4, EUS had a pooled sensitivity of 92.4% (95% CI: 89.2-95.0) and specificity of 97.4% (95% CI: 96.6-98.0). With Fine Needle Aspiration (FNA), sensitivity of EUS to diagnose N stage improved from 84.7% (95% CI: 82.9-86.4) to 96.7% (95% CI: 92.4-98.9). The P value for the χ2 test of heterogeneity for all pooled estimates was > 0.10. CONCLUSION: EUS has excellent sensitivity and specificity in accurately diagnosing the TN stage of esophageal cancer. EUS performs better with advanced (T4) than early (T1) disease. FNA substantially improves the sensitivity and specificity of EUS in evaluating N stage disease. EUS should be strongly considered for staging esophageal cancer. | Srinivas R Puli Jyotsna BK Reddy Matthew L Bechtold Daphne Antillon Jamal A Ibdah Mainor R Antillon | 2008 | World Journal of Gastroenterology2008,14,10: | 55 |
| 2 | How good is endoscopic ultrasound for TNM staging of gastric cancers? A meta-analysis and systematic review显示文摘AIM: To evaluate the accuracy of endoscopic ultrasound (EUS) for staging of gastric cancers. METHODS: Only EUS studies confirmed by surgery were selected. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Articles were searched in Medline, Pubmed, Ovid journals, Cumulative index for nursing & allied health literature, International pharmaceutical abstracts, old Medline, Medline nonindexed citations, and Cochrane control trial registry. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. 2 × 2 tables were constructed with the data extracted from each study. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specifi city, likelihood ratios, and diagnostic odds ratio. Pooling was conducted by both the Mantel-Haenszel method (fi xed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran's Q test based upon inverse variance weights. RESULTS: Initial search identified 1620 reference articles and of these, 376 relevant articles were selected and reviewed. Twenty-two studies (n = 1896) which met the inclusion criteria were included in this analysis. Pooled sensitivity of T1 was 88.1% (95% CI: 84.5-91.1) and T2 was 82.3% (95% CI: 78.2-86.0). For T3, pooled sensitivity was 89.7% (95% CI: 87.1-92.0). T4 hada pooled sensitivity of 99.2% (95% CI: 97.1-99.9). For nodal staging, the pooled sensitivity for N1 was 58.2% (95% CI: 53.5-62.8) and N2 was 64.9% (95% CI: 60.8-68.8). Pooled sensitivity to diagnose distant metastasis was 73.2% (95% CI: 63.2-81.7). The P for chi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION: EUS results are more accurate with advanced disease than early disease. If EUS diagnoses advanced disease, such as T4 disease, the patient is 500 times more likely to have true anatomic stage of T4 disease. | Srinivas Reddy Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Mainor R Antillon Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008,14,25: | 33 |
| 3 | Endoscopic ultrasound:It’s accuracy in evaluating mediastinal lymphadenopathy? A meta-analysis and systematic review显示文摘AIM:To evaluate the accuracy of endoscopic ultrasound (EUS), EUS-fine needle aspiration (FNA) in evaluating mediastinal lymphadenopathy. METHODS:Only EUS and EUS-FNA studies confirmed by surgery or with appropriate follow-up were selected. Articles were searched in Medline, Pubmed, and Cochrane control trial registry. Only studies from which a 2 × 2 table could be constructed for true positive, false negative, false positive and true negative values were included. Two reviewers independently searched and extracted data. The differences were resolved by mutual agreement. Meta-analysis for the accuracy of EUS was analyzed by calculating pooled estimates of sensitivity, specificity, likelihood ratios, and diagnostic odds ratios. Pooling was conducted by both Mantel-Haenszel method (fixed effects model) and DerSimonian Laird method (random effects model). The heterogeneity of studies was tested using Cochran’s Q test based upon inverse variance weights. RESULTS:Data was extracted from 76 studies (n = 9310) which met the inclusion criteria. Of these, 44 studies used EUS alone and 32 studies used EUS-FNA. FNA improved the sensitivity of EUS from 84.7% (95% CI:82.9-86.4) to 88.0% (95% CI:85.8-90.0). With FNA, the specificity of EUS improved from 84.6% (95% CI:83.2-85.9) to 96.4% (95% CI:95.3-97.4). The P forchi-squared heterogeneity for all the pooled accuracy estimates was > 0.10. CONCLUSION:EUS is highly sensitive and specific for the evaluation of mediastinal lymphadenopathy and FNA substantially improves this. EUS with FNA should be the diagnostic test of choice for evaluating mediastinal lymphadenopathy. | Srinivas R Puli Jyotsna Batapati Krishna Reddy Matthew L Bechtold Jamal A Ibdah Daphne Antillon Shailender Singh Mojtaba Olyaee Mainor R Antillon | 2008 | World Journal of Gastroenterology2008,14,19: | 10 |
| 4 | Asian emissions in 2006 for the NASA INTEX-B mission显示文摘 | Zhang Q. Streets D. G. Carmichael G. R. He K. B. Huo H. Kannari A. Klimont Z. Park I. S. Reddy S. Fu J. S. Chen D. Duan L. Lei Y. Wang L. T. Yao Z. L | 2009 | 2009 (173)2009,,173: | 5 |
| 5 | 骨形态发生蛋白15基因多态性与复发性葡萄胎和习惯性流产的相关性研究显示文摘目的探讨骨形态发生蛋白15(BMP15)基因多态性与复发性葡萄胎(RHMs)和习惯性流产(RSAs)的相关性。方法收集2012年10月-2013年9月在加拿大麦吉尔大学人类健康中心妇产科治疗的77例不同种族的RHMs和习惯性流产妇女的血液标本,采用基因外显子测序分析患者BMP15基因的多态性,并采用蛋白功能预测软件预测各SNPs对BMP15蛋白功能的影响。结果在BMP15基因2个外显子中共检测到5个错义突变和1个插入突变。其中在外显子1中检测到2个错义突变(p.S5R和p.N103S);在外显子2中检测到3个错义突变(p.L148P,p.A180T,p.H200Y)和1个插入突变,(p.Leu263dup)。通过预测,p.L148P突变可能会严重影响BMP15蛋白的活性进而影响卵巢功能,而p.S5R突变的影响相对较小,其余SNPs对BMP15蛋白功能基本无影响。结论 BMP15基因突变除了可能与RHMs和习惯性流产妇女的卵泡生成障碍及卵巢功能早衰相关,还可能导致葡萄胎恶变。 | 王鹤 Ramesh Reddy Ngoc Minh Phuong Nguyen Seang L Tan Rima Slim | 2017 | 中国妇幼保健2017,32,11: | 2 |
| 6 | Asian emissions in 2006 for the NASA INTEX-B mission显示文摘 | Zhang Q. Streets D. G. Carmichael G. R. He K. B. Huo H. Kannari A. Klimont Z. Park I. S. Reddy S. Fu J. S. Chen D. Duan L. Lei Y. Wang L. T. Yao Z. L | 2009 | Atmospheric Chemistry and Physics2009,,173: | 2 |
| 7 | Spatial Variability of Soil Properties and Weed Population in the Mississippi Delta 显示文摘 | Gaston L A Locke M A Zablotowicz R M Reddy K N | 1999 | Soil Science Bulletin1999,44,8: | 2 |
| 8 | Functional analysis ofthe domain structure of tumor necrosis factor-alpha converting enzyme显示文摘 | Reddy P Slack J L Davis R | | 0,,: | 2 |
| 9 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Nelssen J L Reddy P G | 1990 | J Anim Sci1990,68,6: | 1 |
| 10 | Activation of Akt (PKB) and suppression of FKHRL1 in mouse and rat oocytes by stem cell factor during follicular activation and development显示文摘 | Reddy P Shen L Ren C | 2005 | Dev Biol2005,281,2: | 1 |
| 11 | Transient hypersensitivity to soybean meal in the early-weaned pig显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | Animal Science1990,68,: | 1 |
| 12 | Soy protein concentrate and heated soy flours as protein sources in milk replacer for preruminant calves显示文摘 | Dawson D P Morrill J L Reddy P G | 1988 | J Dairy Sci1988,71,: | 1 |
| 13 | The electrocardiology of right ventricular myocardial infarction显示文摘 | Reddy GV Schamroth L | 1986 | Chest1986,,05: | 1 |
| 14 | The solubility relationships of calcium and magnesium minerals in processed oil shales显示文摘 | Reddy K J Lindsay W L | 1986 | Journal of En- vironmental Quality1986,15,1: | 1 |
| 15 | Developing microsatellite DNA markers in pecan显示文摘 | GRAUKE L IQBAL M REDDY A | 2003 | J Am Soc Hortic Sci2003,128,: | 1 |
| 16 | Carbon and chlorine isotope effects during abiotic reductive dechlorination of polychlorinated ethanes 显示文摘 | Hofstetter T B Reddy C M Heraty L J | 2007 | Environ Sci Technol2007,41,13: | 1 |
| 17 | Reflectance indices with precision and accuracy in predicting cotton leaf nitrogen concentration显示文摘 | Tarpley L Reddy K R Gretchen FSC | 2000 | Crop Science2000,40,: | 1 |
| 18 | COMPACTEST: A Method to Generate Compact Test Set for Combinational Circuits显示文摘 | I Pomeranz L N Reddy S M Reddy | 1993 | IEEE Trans on CAD of Integrated Circuits and Systems1993,12,7: | 1 |
| 19 | Transient hypersensitivity to soybean meal in the early weaned pig 显示文摘 | Li D F Nelssen J L Reddy P G | 1990 | Journal of Animal Science1990,68,: | 1 |
| 20 | SVD based information theoretic criteria for detection of the number of sinusoids 显示文摘 | L S Biradar V U Reddy | 1990 | ICASSP-901990,5,: | 1 |