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| 1 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 2 | Organoclay sorption of benzene as a function of total organic carbon content 显示文摘 | Redding A Z Bums S E Upson R T | 2002 | J Colloid interface Sci2002，250，： | 1 |
| 3 | Prevalence and impact of gastroesophageal reflux in adolescents with asthma: a population-based study 显示文摘 | Debley J S Carter E R Redding G J | 2006 | Pediatr Pulmonol2006，41，5： | 1 |
| 4 | Physicochemical properties of KF-NaF-AlF3 molten electrolytes显示文摘 | Apisarov A P Dedyukhin A E Red'kin A A | | 0，，06： | 1 |
| 5 | An Open Device Driver Architecture for Direct Machining and Control显示文摘 | Wei Li Red E Jensen G | 2005 | Computer-Aided Design and Applications2005，2，14： | 1 |
| 6 | A Dynamic Optimal Trajectory Generator for Cartesian Path Following显示文摘 | Red E | 2000 | Robotica2000，18，： | 1 |
| 7 | Direct Process Control Using n_Dimensional NURBS Curves显示文摘 | Cheatham R Red E Jensen G | 2005 | Computer-Aided Design and Applications2005，2，5： | 1 |
| 8 | On-line Cartesian Trajectory Control of Mechanisms Along Complex Curves显示文摘 | Zhaoxue Y Red E | 1997 | Robotica1997，15，： | 1 |
| 9 | Hydrogen Leak Test Is Minimally Invasive and Highly Specific for Assessment of the Integrity of the Luminal Closure after Natural Orifice Transluminal Endoscopic Surgery Procedures显示文摘 | Dray X Redding S K Shin E J | 2009 | Gastrointest Endose2009，69，31： | 1 |
| 10 | Occurrence and accumulation of pesticides and organic contaminants in river sediment,water and clam tissues from the San Joaquin river and tributaries,California显示文摘 | Wilf red E D Pereira L Joseph | 1996 | Environmental Toxicology and Chemistry1996，15，2： | 1 |
| 11 | In vivo and in vitro sweling of cell walls during fruit ripening显示文摘 | Red Gwell R J Macrae E Hallett I | 1997 | Planta1997，203，2： | 1 |
| 12 | New developments in stratigraphy and petroleum-geological evolution显示文摘 | Bunter M A G Abdel M A E M The Sudanese Red Sea:1 | 1989 | Journal of Petroleum Geology1989，12，2： | 1 |
| 13 | Inequality and Unemployment in a Global Economy显示文摘 | Helpman E Itskhoki O Redding S | 2010 | Econometrica2010，78，4： | 1 |
| 14 | Organoclay sorption of benzene as function of total organic carbon content显示文摘 | Redding A Z Burns S E Upson R T | 2002 | Journal of Colloid and Interface Science2002，250，1： | 1 |
| 15 | Inequality and unemployment in a global economy 显示文摘 | I-IELPMAN E ITSKHOKI O REDDING S J | 2010 | Econometrica2010，78，4： | 1 |
| 16 | Tool seleetion for five-axis curvature matehed maehining 显示文摘 | Jensen C G Red W E Pi J | 2002 | Computer-Aided De- sign2002，34，3： | 1 |
| 17 | Lubricants with ultra-disperse diamond-graphite powder显示文摘 | RED'KIN V E | 2004 | Chemistry and Technology of Fuels and Oils2004，40，3： | 1 |
| 18 | ferntgineus显示文摘 | RANDALL J E ORMOND R E On the Red Sea parrotfishes of Forsskhl Scants psittacus and S | 1978 | Zool J Linn Soc1978，63，3： | 1 |
| 19 | Robotic TCF and rigid-body calibration methods显示文摘 | WANG Xuguang RED E | 1997 | Robotica1997，15，6： | 1 |
| 20 | Organoclay sorption of benzene as a function of total organic carbon content 显示文摘 | Redding A Z Burns S E | 2002 | Journal of Colloid and Interface Science2002，250，1： | 1 |
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