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| 1 | Colorectal cancer risk in hamartomatous polyposis syndromes显示文摘Colorectal cancer(CRC) is a major cause of morbidity and mortality around the world, and approximately 5% of them develop in a context of inherited mutations leading to some form of familial colon cancer syndromes. Recognition and characterization of these patients have contributed to elucidate the genetic basis of CRC. Polyposis Syndromes may be categorized by the predominant histological structure found within the polyps. The aim of the present paper is to review the most important clinical features of the Hamartomatous Polyposis Syndromes, a rare group of genetic disorders formed by the peutz-Jeghers syndrome, juvenil polyposis syndrome and PTEN Hamartoma Tumor Syndrome(Bannayan-Riley-Ruvalacaba and Cowden Syndromes). A literature search was performed in order to retrieve the most recent and important papers(articles, reviews, clinical cases and clinical guidelines) regarding the studied subject. We searched for terms such as 'hamartomatous polyposis syndromes', 'Peutz-Jeghers syndrome', 'juvenile polyposis syndrome', 'juvenile polyp', and 'PTEN hamartoma tumour syndrome'(Cowden syndrome, Bananyan-Riley-Ruvalcaba). The present article reports the wide spectrum of disease severity and extraintestinal manifestations, with a special focus on their potential to develop colorectal and other neoplasia. In the literature, the reported colorectal cancer risk for Juvenile Polyposis, Peutz-Jeghers and PTEN Hamartoma Tumor Syndromes are 39%-68%, 39%-57% and 18%, respectively. A review regarding cancer surveillance recommendations is also presented. | Fábio Guilherme Campos Marleny Novaes Figueiredo Carlos Augusto Real Martinez | 2015 | World Journal of Gastrointestinal Surgery2015，7，3： | 7 |
| 2 | Duodenal adenoma surveillance in patients with familial adenomatous polyposis显示文摘Familial adenomatous polyposis(FAP) is a hereditary disorder caused by Adenomatous Polyposis Gene mutations that lead to the development of colorectal polyps with great malignant risk throughout life. Moreover, numerous extracolonic manifestations incorporate different clinical features to produce varied individual phenotypes. Among them, the occurrence of duodenal adenomatous polyps is considered an almost inevitable event, and their incidence rates increase as a patient's age advances. Although the majority of patients exhibit different grades of duodenal adenomatosis as they age, only a small proportion(1%-5%) of patients will ultimately develop duodenal carcinoma. Within this context, the aim of the present study was to review the data regarding the epidemiology, classification, genetic features, endoscopic features, carcinogenesis, surveillance and management of duodenal polyps in patients with FAP. | Fábio Guilherme Campos Marianny Sulbaran Adriana Vaz Safatle-Ribeiro Carlos Augusto Real Martinez | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，10： | 3 |
| 3 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 4 | Gene expression signatures predict outcome in non-muscle-invasive bladder carcinoma:a multicenter validation study显示文摘 | Dyrskjt L Zieger K Real F X | 2007 | Clinical Cancer Res2007，13，12： | 1 |
| 5 | Iron-substituted lithium titanium spinels:Structural and electrochemical characterization显示文摘 | Reale P Panero S Ronci F | 2003 | Chem Mater2003，15，： | 1 |
| 6 | Degradation of Carbofuran by Using Ozone,UV Radiation and Advanced Oxidation Processes显示文摘 | BENITEZ F J ACERO J L REAL F J | 2002 | Journal of Hazardous Materials2002，89，： | 1 |
| 7 | Organo/LDH nanocomposite as an adsorbent of polycyclic aromatic hydrocarbons in water and soil--water systems 显示文摘 | Bruna F Cells R Real M | 2012 | Journal of Hazardous Materials2012，，： | 1 |
| 8 | Removal of phenyl-urea herbicides in ultrapure water by ultrafiltration and nanofiltration processes显示文摘 | Benitez F J Acero J L Real F J | 2009 | Water Research2009，43，2： | 1 |
| 9 | Essential interactions between Thiobacillus ferrooxidans and heterotrophic microorganisms during a wastewater sludge bioleaching process显示文摘 | Real L Denis C | 1998 | Environmental pollution1998，101，： | 1 |
| 10 | 显示文摘 | Reale P Bonino F | 2000 | Solid State Ionics2000，128，： | 1 |
| 11 | Glassy cell carcinoma of the cervix : report of three cases 显示文摘 | Johnston GA Jr Azizi F Reale F | 1982 | J Natl Med Assoc1982，74，4： | 1 |
| 12 | Oxidation of MCPA and 2,4-D by UV radiation,ozone,and the combinations UV/H O and O/H O显示文摘 | Benitez F J Acero J L Real F J | 2004 | Journal of 2 2 3 2 2Environmental Science and Health Part B2004，39，3： | 1 |
| 13 | Diagnostic imaging of hyaline membrane disease显示文摘 | Peschechera R Andrisani MC Reale F | 2004 | Rays2004，29，2： | 1 |
| 14 | Oxidationprocesses applied to the elimination of chlorpyrifos and aceto-chlor in aqueous solutions 显示文摘 | BENITEZ F J REAL F J GONZALEZ M | 2006 | Fresenius Environmental Bulle-tin2006，15，12： | 1 |
| 15 | Kinetics of trichloroethene dechlorination and methane formation by a mixed anaerobic culture in a bio-electrochemical system 显示文摘 | Aulenta F Reale P Catervi A Panero S Majone M | 2008 | Electrochim Acta2008，53，16： | 1 |
| 16 | Microbial reductive dechlorination of trichloroethene to ethene with electrodes serving as electron donors without the external addition of redox mediators 显示文摘 | Aulenta F Canosa A Reale P Rossetti S Panero S Majone M | 2009 | Biotechnol Bioeng2009，103，1： | 1 |
| 17 | Primary intraventricularhe-morrhage in adults 显示文摘 | Passero S Ulivelli M Reale F | 2002 | Acta Neurol Scand2002，105，2： | 1 |
| 18 | Primary intraventricular hemor- rhage in adults 显示文摘 | Passero S Ulivelli M Reale F | 2012 | Acta Neurol Scand2012，105，2： | 1 |
| 19 | Chlorination of organophosphorus pesticides in natural waters显示文摘 | Acero J L Benitez F J Real F J | 2008 | Journal of Hazardous Materials2008，153，12： | 1 |
| 20 | Responses induced by high concentration of cadmium in Phragmites australis roots 显示文摘 | EDERLI L REALE L FERRANTI F | 2004 | Physiologia Plantarum2004，121，1： | 1 |
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