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| 1 | Saposin C stimulates growth and invasion,activates p42/44 and SAPK/JNK signaling pathways of MAPK and upregulates uPA/uPAR expression in prostate cancer and stromal cells显示文摘Aim: To determine the effect of saposin C (a known trophic domain of prosaposin) on proliferation, migration and invasion, as well as its effect on the expression of urokinase plasmonogen activator (uPA), its receptor (uPAR) and matrix metalloproteinases (MMP)-2 and -9 in normal and malignant prostate cells. In addition, we tested whether saposin C can activate p42/44 and stress-activated protein kinase/c-Jun NH2-terminal kinase (SAPK/JNK) signal transduction pathways of the mitogen-activated protein kinase (MAPK) superfamily. Methods: We employed Western blot analysis, phospho-specific antibodies, cell proliferation assay, reverse transcriptase-polymerase chain reaction,in vitro kinase assays and migration and invasion to determine the effect of saposin C on various biological behaviors of prostate stromal and cancer cells. Results: Saposin C, in a cell type-specific manner, upregulates uPA/uPAR and immediate early gene c-Jun expression, stimulates cell proliferation, migration and invasion and activates p42/44 and SAPK/JNK MAPK pathways in prostate stromal and cancer cells. Normal prostate epithelial cells were not responsive to saposin C treatment in the above studies. Conclusion: Saposin C functions as a multipotential modulator of diverse biological activities in prostate cancer and stromal cells. These results strongly suggest that saposin C functions as a potent growth factor for prostatic cells and may contribute to prostate carcinogenesis and/or the development of hormone-refractory prostate cancer. | Shahriar Koochekpour Oliver Sartor Masao Hiraiwa Tae-Jin Lee Walter Rayford Natascha Remmel Konrad Sandhoff ArdalanMinokadeh DavidY.Patten | 2005 | Asian Journal of Andrology2005，7，2： | 7 |
| 2 | Uranium reduction by desulfovibrio desulfuricans strain G20 and a cytochrome c3 mutant 显示文摘 | Rayford B P Darren M G Barbara J R | 2002 | Applied and Environmental Microbiology2002，68，6： | 1 |
| 3 | Carboxyl - containing Starch Graft Polymer: Preparation and Use in Heavy Metal Removal显示文摘 | RAYFORD W E WING R E DOANE W M | 1979 | J Appl Polym Sci1979，，24： | 1 |
| 4 | Identification of cholecystokinin-secreting cells 显示文摘 | POLAK JM BLOOM SR RAYFORD PL | 1975 | Lancet1975，2，7943： | 1 |
| 5 | Modulation of fibrinolysis by ionizing radiation显示文摘 | Jasti S. Rao Alan Rayford Masaaki Yamamoto K. Kian Ang Philip Tofilon Raymond Sawaya | 1994 | Journal of Neuro - Oncology1994，，2： | 1 |
| 6 | Muscarinic cholinergic receptors promote growth of human prostate cancer cells显示文摘 | Rayford W Noble MJ Austenfeld MA | 1997 | Prostate1997，30，3： | 1 |
| 7 | Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells显示文摘 | Li X Rayford H Shu R | 2004 | Am J Physiol Lung CellMol Physiol2004，287，1： | 1 |
| 8 | Smoki and pancreatic disorder 显示文摘 | Chowdhury P Rayford PL | 2000 | Eur J Gastroenterol Hepatol2000，12，8： | 1 |
| 9 | Carboxyl-containing Starch Graft Polymer: Preparation and Use in Heavy Metal Removal显示文摘 | Rayford W E Wing R E Doane W M | 1979 | J Appl Polym Sci1979，，24： | 1 |
| 10 | Expression of tissue inhibitors of metalloproteinases: negative regulators of human glioblastoma invasion in vivo 显示文摘 | Mohanam S Wang SW Rayford A | 1995 | Clin Exp Metastasis1995，13，1： | 1 |
| 11 | Overexpression and localization of cathepsin B during the progression of human gliomas显示文摘 | Marupudi Sivaparvathi Raymond Sawaya Shang Wu Wang Alan Rayford Masaaki Yamamoto Lance A. Liottat Garth L. Nicolson Jasti S. Rao | 1995 | Clinical & Experimental Metastasis1995，，1： | 1 |
| 12 | Essential roles for angiotensin receptor ATla in Neomycin-induced apoptosis and lung fibrosis in mice显示文摘 | Li X Rayford H Uhal BD | 2003 | Am J Patho12003，163，6： | 1 |
| 13 | Essential roles for angiotensin receptor ATla in bleomycin-induced apoptosis and lung ? brosis in mice 显示文摘 | Li X Rayford H Uhal BD | 2003 | Am J Pathol2003，163，： | 1 |
| 14 | Attenuation of bleomycin-induced pulmonary bmsis by intratracheal administration of antisense oligonucleotides against angiotensinogen mRNA 显示文摘 | Li X Zhuang J Rayford H | 2007 | Curr Pharm Design2007，13，： | 1 |
| 15 | Molecular mapping genes conditioning reduced palmitic add content in N87-2122-4soybean显示文摘 | Li Z Wilson R F Rayford W E | 2002 | Crop Science2002，42，： | 1 |
| 16 | Heavy Metal Removel Processes for Some Rinse Water from Electroless Plating of Copper 显示文摘 | Wing R E Rayford W E | 1977 | Plating Surface Fin1977，，10： | 1 |
| 17 | Muscarinic cholinergic receptors promote growth of human prostate cancer cells显示文摘 | Rayford W Noble MJ Austenfeld MA | 1997 | Prostate1997，30，3： | 1 |
| 18 | Essential roles for angiotensin receptor ATIa in bleomycin -induced apoptosis and lung fibrosisin in ice 显示文摘 | Li X Rayford H Uhal BD | 2003 | Am J Pathol2003，163，6： | 1 |
| 19 | Methanol Conversion on SAPO-34 with Reaction Condition for Fixed-bed Reactor显示文摘 | Michael Rayford G | 2004 | Applied Catalysis2004，60，12： | 1 |
| 20 | Essential roles for angiotensin receptor ATIa in bleomycin-induced apoptosis and lung fibrosis in mice 显示文摘 | Li XP Rayford H Uhal BD | 2003 | Am J Pathol2003，163，6： | 1 |
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