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| 1 | Mutifactorial analysis of risk factors for reduced bone mineral density in patients with Crohn’s disease显示文摘AIM: To determine the prevalence of osteoporosis in a cohort of patients with Crohn’s disease (CD) and to identify the relative significance of risk factors for osteoporosis. METHODS: Two hundred and fifty-eight unselected patients (92 M, 166 F) with CD were studied. Bone mineral density (BMD) was measured at the lumbar spine and hip by dual X-ray absorptiometry. Bone formation was assessed by measuring bone specific alkaline phosphatase (BSAP) and bone resorption by measuring urinary excretion of deoxypyridinoline (DPD) and N-telopeptide (NTX). RESULTS: Between 11.6%-13.6% patients were osteoporotic (T score < -2.5) at the lumbar spine and/or hip. NTX levels were significantly higher in the patients with osteoporosis (P < 0.05) but BSAP and DPD levels were not significantly different. Independent risk factors for osteoporosis at either the lumbar spine or hip were a low body mass index (P < 0.001), increasing corticosteroid use (P < 0.005), and male sex (P < 0.01). These factors combined accounted for 23% and 37% of the reduction in BMD at the lumbar spine and hip respectively. CONCLUSION: Our results confirm that osteoporosis is common in patients with CD and suggest that increased bone resorption is the mechanism responsible for thebone loss. However, less than half of the reduction in BMD can be attributed to risk factors such as corticosteroid use and low BMI and therefore remains unexplained. | Sarah A Bartram Robert T Peaston David J Rawlings David Walshaw Roger M Francis Nick P Thompson | 2006 | World Journal of Gastroenterology2006，12，35： | 2 |
| 2 | Nucleotide and amino acid sequence variations in the L1 and E7 open reading frames of human papillomavirus type 6 and type 16显示文摘 | Sathya P Rawls W E | 1991 | Virology1991，184，： | 1 |
| 3 | Carcinoma of the vagi- na-experience at the princess margaret hospital显示文摘 | Kirkbride P Fyles A Rawlings GA | 1995 | Gynecol On- col1995，56，： | 1 |
| 4 | Glass-ceramics:their production from wastes-a review显示文摘 | Rawlings R D Wu J P Boccaccini A R | 2006 | J Mater Sci2006，41，： | 1 |
| 5 | Increased plasma concen trations of lipoprotein(a) during a low-fat, high-carbohydrate diet are associated with increased plasma concentrations of apolipopro- rein C-Ⅲ bound to apolipoprotein B-containing lipoproteins显示文摘 | Shin M J Blanche P J Rawlings RS | 2007 | Am J Clin Nutr2007，85，6： | 1 |
| 6 | Ultrasonographic study of ovarian follicular dynamics in ewes during the oestrous cycle显示文摘 | Ravindra J P Rawlings N C Evans A C O | 1994 | J Reprod Fertil1994，101，： | 1 |
| 7 | Ovarian function in ewes at the onset of the breeding season 显示文摘 | Artlewski P M Beard A P Rawling N C | 1999 | Anim-Reprod-Sci1999，57，2： | 1 |
| 8 | The idea of policing: a history 显示文摘 | Rawlings P | 1995 | Policing and Society1995，，5： | 1 |
| 9 | What contributes more strongly to predicting QOL during 1-year recovery from treatment for clinically localized prostate cancer: 4-weeks-post-treatment depressive symptoms or type of treatment? 显示文摘 | Monahan P O Champion V Rawl S | 2007 | Quality of Life Re- search2007，16，3： | 1 |
| 10 | Infection after ERCP,and antibi- otic prophylaxis:a sequential quality-improvement approach over 11 years 显示文摘 | Cotton PB Connor P Rawls E | 2008 | Gastrointest Endosc2008，67，3： | 1 |
| 11 | Soil detachment by single raindrops of varying kinetic energy 显示文摘 | SHARMA P P GUPTA S C RAWLS W J | 1991 | Soil Science Society of Ameri- ca Journal1991，55，： | 1 |
| 12 | Follicular waves and circulating gonadotrophins in l-month old prepubettal heifers显示文摘 | Adams G P Evans A C O Rawlings N C | 1994 | J Reprod Fertil1994，100，： | 1 |
| 13 | Glass-ceramics: their production from wastes-a review 显示文摘 | RAWLINGS R D WU J P BOCCACCINI A R | 2006 | J Mater Sci2006，41，3： | 1 |
| 14 | Glass-ceramics: Their production from wastes-a review 显示文摘 | Rawlings R D Wu J P Boccaccini A R | 2006 | Journal of Materials Science2006，41，2： | 1 |
| 15 | Infection after ERCP, an(/ antibiotic prophylaxis: a sequential quality-improvement approach over 11 years 显示文摘 | Cotton PB Connor P Rawls E | 2008 | Gastrointest Endosc2008，67，3： | 1 |
| 16 | Constrained model predictive control:Stability and optimality显示文摘 | Mayne D Q Rawlings J B Rao C V Scokaert P O M | | 0，，06： | 1 |
| 17 | Constrained Model Predictive Control: Stability and Optimality 显示文摘 | D Q Mayne J B Rawlings C V Rao & P O M Scokaert | 2000 | Automatica2000，36，： | 1 |
| 18 | Cloning, isolation, and characterization of mammalian legumain, an asparaginylendopeptidase 显示文摘 | Chen J M Dando P M Rawlings N D | 1997 | Biological Chemistry1997，272，12： | 1 |
| 19 | Evaluation of a selective neurectomy model for low urethral pressure incontinence in female dogs 显示文摘 | Rawlings C A Coates J R Purinton P T | 2005 | Am J Vet Res2005，66，4： | 1 |
| 20 | Glassceramics:Their production from wastes-Areview显示文摘 | Rawlings R D Wu J P Boccaccini A R | 2006 | Journal of Materials Science2006，，41： | 1 |
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