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| 1 | F-18 FDG uptake in subcutaneous panniculitis-like T-cell lymphoma显示文摘 | Ravizzini G Meirelles GS Horwitz SM | 2008 | Clin Nucl Med2008，33，12： | 1 |
| 2 | Prognostic val- ue of baseline fluorodeoxyglucose positron emission tomography and 99mTc-MDP bone scan in progressing meta- static prostate cancer显示文摘 | Meirelles G S Schoder H Ravizzini G C | 2010 | Clin Cancer Res2010，16，24： | 1 |
| 3 | Hygromenic resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Ortiz J P A Reggiardo M I Ravizzini R A | 1996 | Plant Cell Reports1996，，15： | 1 |
| 4 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation 显示文摘 | Ortiz JPA Reggiardo MI Ravizzini RA | 1996 | Plant Cell Reports1996，15，： | 1 |
| 5 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Juan Pablo A Ortia Martin 1 Reggiardo Ricardo A Ravizzini | | 0，，： | 1 |
| 6 | Hygromycin re- sistance as an efficient selectable marker for wheat stable transfor- mation 显示文摘 | Ortiz J P A Reggiardo M 1 Ravizzini R A | 1996 | Plant Cell Res1996，15，： | 1 |
| 7 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Ortiz J P A Reggiardo M L Ravizzini R A | 1996 | Plant Cell Reports1996，15，12： | 1 |
| 8 | New horizons in prostate cancer imaging显示文摘 | Ravizzini G Turkby B Kurdziel K | 2009 | Eur J Radiol2009，70，2： | 1 |
| 9 | Hy- gromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | ORRTIZ J P A REGGIARDO M RAVIZZINI R | 1996 | Plant Cell Reports1996，15，12： | 1 |
| 10 | Primary puhno nary meningioma manifesting as a solitary pulmonary nodule with a false-positive PET scan显示文摘 | Meirelles G S Ravizzini G Moreira A L | 2006 | J Thorac Imaging2006，21，3： | 1 |
| 11 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Ortiz J P A Reggiardo M I Ravizzini R A | 1996 | Plant Cell Reports1996，15，： | 1 |
| 12 | Prospective val- ue of baseline fluorodeoxyglucose positron emission tomo- graphy and ^99mTc-MDP bone scan in progressing metastatic pros- tate cancer显示文摘 | Meirelles GSP Schoder H Ravizzini GC | 2010 | Clin Cancer Res2010，16，24： | 1 |
| 13 | Hygromycin re- sistance as an efficient selectable marker for wheat stable transfor- mation 显示文摘 | Ortiz J P A Reggiardo M I Ravizzini R A | 1996 | Plant Cell Rep1996，15，： | 1 |
| 14 | Hygromy- cin resistance as an efficient selectable marker for wheat sta- ble transformation显示文摘 | Ortiz J P A Reggiardo M I Ravizzini R A | 1996 | Plant Cell Rep1996，15，12： | 1 |
| 15 | New horizons in prostate cancer imaging显示文摘 | Ravizzini G Turkbey B Kurdziel K | 2009 | Eur J Radiol2009，70，2： | 1 |
| 16 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Pablo J Ortiz A Reggiardo M I Ravizzini R A Altabe S G Gerardo D L Cervigni Spitteler M A Morata M M Elias F E Vallejosall R H | 1996 | Plant Cell Rep1996，15，12： | 1 |
| 17 | Microdissection testicular sperm extraction and IVF-ICSI outcome in nonobstructive azoospermia显示文摘 | RAVIZZINI P CARIZZA C ABDELMASSIH V | 2008 | Andrologia2008，40，4： | 1 |
| 18 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation显示文摘 | Ortiz J P A Reggiardo M I Ravizzini R A et ol | 1996 | Plant Cell Reports1996，15，： | 1 |
| 19 | Hygromycin resistance as an efficient selectable marker for wheat stable transformation 显示文摘 | Ortiz J P A Reggiardo M L Ravizzini R A | 1996 | Plant Cell Reports1996，15，12： | 1 |
| 20 | Disease control and failure patterns of unresectable hepatocellular carcinoma following transarterial radioembolization with yttrium-90 microspheres and with/without sorafenib显示文摘BACKGROUND Impressive survival outcome of our previous study in unresectable hepatocellular carcinoma(HCC)patients undergoing yttrium-90 glass microspheres transarterial radioembolization(TARE)with/without sorafenib according to individuals’disease burden,i.e.,intrahepatic tumor load(IHT)and adverse disease features(ADFs)might partly be confounded by other treatments and underlying hepatic function.Therefore,a dedicated study focusing on treatment response and assessment of failure patterns might be a way to improve treatment outcome in addition to patient selection based on the disease burden.AIM To assess the tumor response,disease control and patterns of disease progression following TARE with/without sorafenib in unresectable HCC patients.METHODS This retrospective study was conducted in successful TARE procedures with available pre-and post-treatment imaging studies(n=169).Three treatment subgroups were(1)TARE only(TARE_alone)for IHT≤50%without ADFs,i.e.,macrovascular invasion,extrahepatic disease(EHD)and infiltrative/ill-defined HCC(n=63);(2)TARE with sorafenib(TARE_sorafenib)for IHT>50%and/or presence of ADFs(n=81);and(3)TARE only for patients who could not receive sorafenib due to contraindication or intolerance(TARE_no_sorafenib)(n=25).Objective response rate(ORR;consisted of complete response(CR)and partial response(PR)),disease control rate(DCR;consisted of CR,PR and stable disease)and failure patterns of treated,intrahepatic and extrahepatic sites were assessed using the modified response evaluation criteria in solid tumors.Time to progression(TTP)was calculated from TARE to the first radiologic progression at any site using Kaplan-Meier method.Identification of prognostic factors for TTP using the univariate Kaplan-Meier method and multivariate Cox proportional hazard model were performed in major population subgroups,TARE_alone and TARE_sorafenib.RESULTS The median radiologic follow-up time was 4.4 mo(range 0.5-48.8).In treated area,ORR was highest in TARE_sorafenib(53.1%),followed by TARE_alone(41.3%)and TARE_no_sorafenib(16%).In intrahepatic area,DCR remained highest in TARE_sorafenib(84%),followed by TARE_alone(79.4%)and TARE_no_sorafenib(44%).The overall DCR was highest in TARE_alone(79.4%),followed by TARE_sorafenib(71.6%)and TARE_no_sorafenib(40%).Dominant failure patterns were intrahepatic for both TARE_alone(44.5%)and TARE_sorafenib(38.4%).Extrahepatic progression was more common in TARE_sorafenib(32%)and TARE_no_sorafenib(40%)than in TARE_alone(12.7%).TTP was longest in TARE_alone(8.6 mo;95%CI:3.4-13.8),followed by TARE_sorafenib(5.1 mo;95%CI:4.0-6.2)and TARE_no_sorafenib(2.7 mo;95%CI:2.2-3.1).Pre-existing EHD(HR:0.37,95%CI:0.24-0.56,P<0.001)was a sole prognostic factor for TTP in TARE_sorafenib with no prognostic factor for TTP in TARE_alone.CONCLUSION TARE with/without sorafenib according to individuals’disease burden provided DCR approximately 70%with intrahepatic progression as dominant failure pattern.Extrahepatic progression was more common in procedures with initially high disease burden. | Ajalaya Teyateeti Armeen Mahvash James Long Mohamed Abdelsalam Rony Avritscher Ahmed Kaseb Bruno Odisio Gregory Ravizzini Devaki Surasi Achiraya Teyateeti Homer Macapinlac Srinivas Cheenu Kappadath | 2021 | World Journal of Gastroenterology2021，27，47： | 0 |
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