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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Nano and microparticles as controlled drug delivery devices 显示文摘 | RAVI KUMAR M N | 2000 | J Pharm Pharm Sci2000，3，2： | 1 |
| 3 | Kinetics of moisture loss and oil uptake during deep fat frying of Gethi(Dioscorea kamoonensis Kunth)strips显示文摘 | MANJUNATHA S S RAVI N NEGIP S | 2012 | Journal of Food Science and Technology2012，51，11： | 1 |
| 4 | A review of chitin and chitosan applications 显示文摘 | Majeti N V Ravi K | 2000 | Reactive and Functional Polymers2000，46，： | 1 |
| 5 | Estimation of tool wear during CNC milling using neural network-based sensor fusion 显示文摘 | Ghosh N Ravi Y B Patra A | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 6 | In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn显示文摘 | Adhirajan N Ravi Kumar T Shanmugasundaram N | 2003 | J Ethnopharmacol2003，88，23： | 1 |
| 7 | Development and evaluation of a competitive ELISA for estimation of rabies neutralizing antibodies after post-exposure rabies vaccination in humans 显示文摘 | Muhamuda K Madhusudana S N Ravi V | 2007 | Int J Infect Dis2007，11，5： | 1 |
| 8 | Effect of hafnium incorporation on the crystallization and mechanical behavior of a Zr-based bulk amorphous alloy 显示文摘 | Baldwin F Ravi Kumar N V Das K | 2008 | Materials Science and Engineering A2008，477，12： | 1 |
| 9 | Estimation of tool wear during CNC milling using neural network-based sensor fusion显示文摘 | GHOSH N RAVI Y B PATRA A | 2007 | Mechanical Systems and Signal Processing2007，21，1： | 1 |
| 10 | A review of chitin and chitosan applications 显示文摘 | Majeti N V Ravi Kumar | 2000 | Reactive & Functional Polymers2000，46，： | 1 |
| 11 | Grain refinement in AZ91 magnesium alloy during thermomechanical processing显示文摘 | RAVI KUMAR N V BLANDIN J J DESRAYAUD C | 2003 | Materials and Engineering A2003，359，： | 1 |
| 12 | Refilling of ocular lens capsule with copolymerie hydrogel containing reversible disulfide 显示文摘 | Aliyar H A ttamihon P D Ravi N | 2005 | Biomacromolecules2005，6，1： | 1 |
| 13 | Magnetic resonance molecular imaging of the Her-2/neu receptor显示文摘 | Artemov D Mori N Ravi R | 2003 | Cancer Res2003，63，： | 1 |
| 14 | Electro-optics of perovskite solar cells显示文摘 | Lin Q Ardalan A Ravi C R N | 2014 | Nature Photonics2014，9，2： | 1 |
| 15 | Max Domains of Attraction of Univariate and Multivariate p-max Stable Laws 显示文摘 | MOHAN N R RAVI S | 1993 | Theory Probability and Its Applications1993，37，4： | 1 |
| 16 | Max Domains of Attraction of Univariate and Multivariate p-max Stable Laws 显示文摘 | Mohan N R Ravi S | 1992 | Theory of Prob- ability and its Applications1992，37，4： | 1 |
| 17 | Nature of growth ofdual titanium boride layers with nanostructured titaniumboride whiskers on the surface of titanium 显示文摘 | Tikekar N M Ravi C K S Sanders T | 2001 | ScriptaMaterialia2001，57，3： | 1 |
| 18 | A review of chitin and chitosan applications显示文摘 | Majeti N V Ravi Kumar | 2004 | Reactive & Functional Polymers2004，46，： | 1 |
| 19 | Flocculation of River Silt Using Chitosan显示文摘 | Ravi D Pillai V N S | 2002 | Wat Res2002，36，： | 1 |
| 20 | Emerging directions of packaging technologies: Semiconductor technology and manufacturing显示文摘 | Ravi M Raj N Vijay W | 2002 | Intel Technology Journal2002，6，2： | 1 |
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