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| 1 | 5-Azacytidine induces changes in electrophysiological properties of human mesenchymal stem cells显示文摘以前,导出髓的干细胞(MSC ) 与不确定的脱氧核糖核酸甲基转移酶禁止者 5-azacytidine 对待的老鼠骨头被报导区分 intocardiomyocytes。现在的学习的目的是在从健康骨髓施主获得的人的单音的原子房间调查类似的区别策略的效率。After1-3 段落,文化为 24 h 暴露于到 6 星期进一步的文化跟随的 5-azacytidine (3 mciroM ) 。药处理没导致 myogenic 标记 MyoD 或心脏的 markersNkx2.5 和 GATA-4 的表示并且没在后续期间产出跳动的房间。在补丁夹钳实验,近似 10-15% 对待,未经治疗的房间展出了 L 类型 Ca (2+) 水流。几乎所有房间表面地出现了修正快速或慢的激活动力学的 K (+) 水流。在与匹配时间的控制相比在 6 星期处理以后加倍的 +60 mV 意味着当前的振幅。对待的房间的 Membranecapacitance 比在在处理以后的 controls2 星期内显著地大并且在 6 个星期以后仍然保持高。为 K (+) 隧道 Kv1.1, Kv1.5, Kv2.1, Kv4.3 和 KCNMA1 并且为 Ca (2+) 隧道 Ca (v) 的 mRNAs 的表示层次 1.2 没被 5-azacytidine 影响。在以前显示出禁止 hMSC 的快速或慢慢地激活的 K (+) 水流的集中的 Treatmentwith 钾隧道块 ers tetraethylammonium 和 clofilium 禁止了这些房间的增长。我们的结果建议尽管有进 cardiomyocytes 的 hMSC 的区别的缺席,有 5-azacytidine 的处理在当前的密度引起了深刻变化。 | Bartosz Balanal Cecilia Nicoletti Ihor Zahanich Eva M Graf Torsten Christ Sabine Boxberger Ursula Ravens | 2006 | Cell Research2006，16，12： | 20 |
| 2 | Using River Habitat Survey for Environmental Assessment and Catchment Planning in the UK显示文摘 | Raven P J Holmes N T H Naura M | 2000 | Hydrobiologia2000，，： | 1 |
| 3 | Theroleoftracemetals in photosynthetic electron transport in O2 evolving orga- nisms 显示文摘 | Raven J A Evans M C W Korb R E | 1999 | Photosynthesis Research1999，60，： | 1 |
| 4 | Biomineralization by photosynthetic or- ganisms: evidence of coevolution of the organisms and their envi- ronment显示文摘 | Raven J A Giordano M | 2009 | Geobiology2009，7，2： | 1 |
| 5 | Microstructural and petrophysical characterization of Muderong Shale : application to top seal risking 显示文摘 | DEWHURST D N JONES R M RAVEN M D | 2002 | Petroleum Geoscience2002，8，： | 1 |
| 6 | Plant mineral nutrition in ancient landscapes: high plant species di versity on infertile soils is linked to functional diversity for nu tritional strategies显示文摘 | LAMBERS H BRUNDRETT M C RAVEN J A | 2010 | Plant and Soil2010，334，12： | 1 |
| 7 | The influence of natural and experimental high O2 concentrations on O2 -evolving phototrophs显示文摘 | Raven J A Johnston A M Parsons R | 1994 | Biological Reviews1994，69，： | 1 |
| 8 | Using river habitat survey for environmental assessment and catchment planning in the UK显示文摘 | RAVEN P J HOLMES N T H NAURA M | 2000 | Hydrobio-logia2000，，： | 1 |
| 9 | Implications of δ13C natural abundance measurements of photosyntbetie performaee by marine macrophytes in their natural environment 显示文摘 | Raven J A Walker A D I Johson M | 1995 | Marine Ecology Progress Series1995，123，13： | 1 |
| 10 | Microstructural and petrophysical characterization of Muderong Shale:Application to top seal risking显示文摘 | DEWHURST D N JONES R M RAVEN M D | 2002 | Petroleum Geoscience2002，8，4： | 1 |
| 11 | The sediFnentary evolution of the red sea and gulf of aden显示文摘 | Crossly R Watkins C Raven M | 1992 | Journal of Petroleum Geology1992，15，2： | 1 |
| 12 | Mechanisms of inorganic carbon acquisition in marine phytoplankton and their implications for the use of other resources显示文摘 | Raven J A Johnston A M | 1991 | Limnology and Oceanography1991，36，： | 1 |
| 13 | Maximal oxy- gen uptake as a parametric measure of cardiorespiratory ca- pacity显示文摘 | Hawkins M N Raven P B Snell P G | 2007 | Med Sci Sports Exerc2007，39，1： | 1 |
| 14 | Measurement of longshore sediment transport rates in the surf zone on Galveston Island, Texas显示文摘 | Rogers A L Ravens T M | 2008 | Journal of Coastal Research2008，24，2： | 1 |
| 15 | Using river habitat survey for environmental, assessment and catchment planning in the UK 显示文摘 | RAVEN P J HOLMES N T H NAURA M | 2000 | Hydrolbiologia2000，，： | 1 |
| 16 | CO2 concentrating mechanisms in algae: mechanisms, environmental modulation, and evolution 显示文摘 | Giordano M Beardall J Raven J A | 2005 | Annual Review of Plant Biology2005，56，： | 1 |
| 17 | Epitaxial growth and critical currents in (013)/(103) -and (110) -oriented YBa2Cu30x films显示文摘 | RAVEN M S INAMETI E E IWAMA S | 1995 | Phys Rev B1995，52，： | 1 |
| 18 | Mouldy houses influence symptoms of asthma among atopic individuals 显示文摘 | Dharmage S Bailey M Raven J | 2002 | Chin Exp Allergy2002，32，： | 1 |
| 19 | Chromosome 4 controls potential water use efficency (δ^13C) in barley 显示文摘 | Handtey L L Nevo E Raven J A MartInez-Carrasco R Serimgcour C M Pakniyat H Forster B P | 1994 | J Exp Bot1994，45，11： | 1 |
| 20 | Decay of the Ar 2pSnd core resonances: An autoionization spectrum dominated by shake processes 显示文摘 | Meyer M Raven E V Sonntag B | 1991 | Physical Review A1991，43，： | 1 |
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