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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Estrogen receptor- mediated signalling in female mice is locally activated in response to wounding显示文摘 | Emmerson E Rando G Meda C | 2013 | Mol Cell Endocrinol2013，375，12： | 1 |
| 3 | Back EMF sensorless-controlalgorithm for high-dynamic performance PMSM显示文摘 | Genduso F Miceli R Rando C | 2010 | IEEE Transa-tions on Industrial Electronics2010，57，6： | 1 |
| 4 | Back EMF sensorless-control algorithm for high-dynamic performance PMSM显示文摘 | Genduso F Miceli R Rando C Galluzzo G R | 2010 | IEEE Transactions on Industrial Electronics2010，57，6： | 1 |
| 5 | Back EMF sensor- less-control algorithm for high-dynamic performance PMSM 显示文摘 | GENDUSO F MICELI R RANDO C | 2010 | IEEE Transactions on Industrial Applications2010，57，6： | 1 |
| 6 | TMJ osteoarthritis: a new approach to diagnosis 显示文摘 | Rando C Waldron T | 2012 | Am J Phys Anthropol2012，148，1： | 1 |
| 7 | Back EMF sensorless con- trol algorithm for high - dynamic performance PMSM 显示文摘 | Genduso F Miceli R Rando C | 2010 | IEEE Transactions on IndustriM Electronics2010，57，6： | 1 |
| 8 | Back EMF sensor- less-control algorithm for high-dynamic performance PMSM 显示文摘 | GENDUSO F MICELI R RANDO C | 2010 | IEEE Transactions on Industrial Electronics2010，57，6： | 1 |
| 9 | Pulmonaiy artery accessembolization in patients with massive hemoptysis in whom tffonchialand/or nonbronchial systemic artery embolization is contraindicated显示文摘 | Tamashiro A Miceli MH Rando C etal | 2008 | Cadiavasc Intervent Radiol2008，31，3： | 1 |
| 10 | Back EMF sensorless-control algorithm for high-dynamic performance PMSM显示文摘 | Genduso F Miceli R Rando C | 2010 | IEEE Transactions on Industrial Electronics2010，57，6： | 1 |
| 11 | Ami- no acid-dependent activation of liver estrogen receptor alpha integrates metabolic and reproductive functions via IGF- I 显示文摘 | DELLA TORRE S RANDO G MEDA C | 2011 | Cell Metabolism2011，13，2： | 1 |
| 12 | Back EMF sensorless-control algorithm for high-dynamic performance PMSM 显示文摘 | Genduso F Miceli R Rando C | 2010 | IEEE Transactions onIndustrial Electronics2010，57，6： | 1 |
| 13 | Wolfram syndrome:Evidence of a diffuse neurodegenerative disease by magnetic resonance imaging显示文摘 | RANDO T A HORTON J C LAYXER R B | 1992 | Neuroiogy1992，42，6： | 1 |
| 14 | Potential acuity meter results in cataract patients显示文摘 | DEVEREUX C J RANDO A WAGSTAFF C M | 2000 | Clin Exp Ophthalmol2000，28，6： | 1 |
| 15 | Back EMF sensorless control algorithm for high-dynamic performance PMSM显示文摘 | Genduso F Micell R Rando C | | 0，，06： | 1 |
| 16 | Dystrophin gene repair in mdx muscle precursor cells in vitro and in vivo mediated by RNA-DNA chimeric oligonucleotides显示文摘 | Bertoni C Rando TA | 2002 | Hum Gene Ther2002，13，6： | 1 |
| 17 | Back EMF Sensorless-control Algorithm for High-dynamic Perfor-mance PMSM 显示文摘 | Genduso F Miceli R Rando C | 2010 | IEEE Trans- actions on Industrial Electronics2010，57，6： | 1 |
| 18 | Back EMF sensorless- control algorithm for high-dynamic performance PMSM 显示文摘 | GENDUSO F MICELI R RANDO C | 2010 | IEEE Transaction on Industrial Applications2010，57，6： | 1 |
| 19 | Changes in mandibular dimensions during the mediaeval to post-mediaeval transition in London : a pos- sible response to decreased masticatory load 显示文摘 | Rando C Hillson S Antoine D | 2014 | Arch Oral Biol2014，59，1： | 1 |
| 20 | Design, implemen tation, and evaluation of an innovative anatomy course 显示文摘 | Rizzolo L J Rando W C O'Brien M K | 2010 | Anat Sci Educ2010，3，3： | 1 |
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