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| 1 | Interstitial cells of Cajal, the Maestro in health and disease显示文摘Interstitial cells of Cajal (ICC) are important players in the symphony of gut motility. They have a very signif icant physiological role orchestrating the normal peristaltic activity of the digestive system. They are the pacemaker cells in gastrointestinal (GI) muscles. Absence, reduction in number or altered integrity of the ICC network may have a dramatic effect on GI system motility. More understanding of ICC physiology will foster advances in physiology of gut motility which will help in a future breakthrough in the pharmacological interventions to restore normal motor function of GI tract. This mini review describes what is known about the physiologic function and role of ICCs in GI system motility and in a variety of GI system motility disorders. | Randa M Mostafa Yasser M Moustafa Hosam Hamdy | 2010 | World Journal of Gastroenterology2010，16，26： | 56 |
| 2 | Rome Ⅲ:The functional gastrointestinal disorders, third edition, 2006显示文摘Functional gastrointestinal disorders (FGIDs) represent a common and important class of disorders within gastroenterology. RomeⅠ, the first edition was published in 1994, with symptom-based diagnostic criteria for FGIDs. These criteria began to change the diagnostic approach to FGIDs, and no longer considered 'diagnoses of exclusion' but rather 'diagnoses of inclusion'. Rome Ⅱ, the second edition published in 2000, resulted from the continual process of analyzing new scientific and clinical evidence in the study of FGIDs. Rome Ⅱ, diagnostic criteria for irritable bowel syndrome (IBS), was extended with a focus on the frequency of symptoms occurring twelve weeks (not necessarily consecutive weeks) within twelve months. ROME Ⅲ, the third edition, conservative one, was published in September 2006, with changes made only where there is good evidence to do so. Some of the differences between Rome Ⅱ and Rome Ⅲ criteria are highlighted in this issue. | Randa Mostafa | 2008 | World Journal of Gastroenterology2008，14，13： | 13 |
| 3 | Functional activity of the rectum:A conduit organ or a storage organ or both?显示文摘瞄准:为了调查直肠的扩张的度是否能定义直肠,作为一根水管或水库工作。方法:到 2 的直肠、肛门的压力的反应直肠的汽球扩张打字,快速的多卷、慢的渐渐的膨胀,在 21 个健康志愿者被记录(12 个男人, 9 个女人,变老 41.7 +/- 10.6 年) 。测试在迫切感觉上与括约肌 squeeze 被重复。结果:快速的多卷的直肠的扩张导致了重要直肠的压力增加(P <
0.001 ) ,肛门压力衰落(P <
0.05 ) 并且汽球逐出。这些题目感到了迫切感觉但是没感到第一直肠的感觉。在迫切感觉上,肛门引起重要直肠的压力减少的 squeeze (P <
0.001 ) 并且紧急消失。慢增长的直肠的充满与一个“音调”拉了 rectometrogram 在直肠的充满期间代表渐渐的直肠的压力增加的手足,和“撤退手足”在汽球逐出期间代表锋利的压力增加。曲线记录了第一直肠的感觉和迫切感觉。结论:直肠显然有二功能:交通(水管) 和存储,两个都取决于直肠的充满的度。如果直肠收到的烘便的材料是小的,它在直肠被存储直到大体积被到达那个罐头影响足够的直肠的扩张的度开始澄清反射。直肠的扩张直接唤起的大体积书籍的右页有产生澄清的肛门禁止的反射。 | Ahmed Shafik Randa M Mostafa Ismail Shafik Olfat EI-Sibai Ali A Shafik | 2006 | World Journal of Gastroenterology2006，12，28： | 1 |
| 4 | Rectal prolapse: Diagnosis and clinical management显示文摘The exact cause of rectal prolapse is not well addressed,but it is often associated with long standing constipation,advanced age,chronic obstructive pulmonary disease and some neurological disorders.Rectal prolapse is usually only a symptom,which needs a focus on discovery of the underlying pathology or disorder.Three different clinical presentations are often combined and called rectal prolapse.Rectal prolapse can be divided into full thickness rectal prolapse where the entire rectum protrudes beyond the anus,mucosal prolapse where only the rectal mucosa (not the entire wall) prolapses,and internal intussuception wherein the rectum collapses but does not exit the anus.Although constipation and straining may contribute to the development of rectal prolapse,simply correcting these problems may not improve the prolapse once it has developed.There are many different approaches to surgical correction of rectal prolapse. | Randa Mohamed Mostafa | 2010 | World Journal of Gastroenterology2010，16，17： | 0 |
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