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| 1 | Potential role of killer immunoglobulin receptor genes among individuals vaccinated against hepatitis B virus in Lebanon显示文摘AIM To explore the role of killer immunoglobulin receptor(KIR) genes in responsiveness or non-responsiveness to vaccination against hepatitis B virus.METHODS We recruited 101 voluntary participants between March 2010 and December 2011. Sera samples from vaccinated and non-vaccinated participants were tested for the presence of anti-HBs antibodies as a measure of protection against hepatitis B, hepatitis B surface antigen and hepatitis B core antibody as indicators ofinfection by enzyme-linked immunosorbent assay. KIR gene frequencies were determined by polymerase chain reaction.RESULTS Sera samples from 99 participants were tested for the levels of anti-HBs as an indicator of protection(≥ 10 mI U/ml) following vaccination as defined by the World Health Organization international reference standard. Among the vaccinated participants, 47%(35/74) had anti-HBs titers above 100 mI U/ml, 22%(16/74) had antiHBs ranging between 10-100 mI U/ml, and 20%(15/74) had values of less than 10 mI U/ml. We report the lack of significant association between the number of vaccine dosages and the titer of antibodies among our vaccinated participants. The inhibitory KIR2Dl1, KIR2Dl4, KIR3Dl1, KIR3Dl2, and KIR3 Dl were detected in more than 95%, whereas KIR2Dl2, KIR2Dl3, KIR2Dl5(KR2Dl5A and KIR2Dl5B) were expressed in 56%, 84% and 42%(25% and 29%) of participants, respectively. The observed frequency of the activating KIR genes ranged between 35% and 55% except for KIR2DS4, detected in 95% of the study participants(40.6% 2DS4*001/002; 82.2% 2DS4*003/007). KIR2DP1 pseudogene was detected in 99% of our participants, whereas KIR3DP*001/02/04 and KIR3DP1*003 had frequencies of 17% and 100%, respectively. No association between the frequency of KIR genes and anti-HBs antibodies was detected. When we compared the frequency of KIR genes between vaccinated individuals with protective antibodies titers and those who lost their protective antibody levels, we did not detect a significant difference. KIR2Dl5 B was significantly different among different groups of vaccinated participants(group Ⅰ > 100 mI U/ml, group Ⅱ 10-100 mI U/ml, group Ⅲ < 10 mI U/ml and group Ⅳ with undetectable levels of protective antibodies). CONCLUSION To our knowledge, this is the first study screening for the possible role of KIR genes among individuals vaccinated against hepatitis B virus(HBV). Our results can be used to design larger studies to better understand the role of KIR genes in protection against or susceptibility to HBV post vaccination. | Nada M Melhem Rami A Mahfouz Khalil Kreidieh Rabab Abdul-Khalik Rolla El-Khatib Reem Talhouk Umayya Musharrafieh Ghassan Hamadeh | 2016 | World Journal of Hepatology2016，8，29： | 2 |
| 2 | Fault-tolerance through scheduling of aperiodic tasks in hard real-time multipro-cessor systems 显示文摘 | Sunondo Ghosh Rami Melhem Daniel Mosse | | IEEE Transactions on Parallel and Distributed Systems0，1997，： | 1 |
| 3 | Faulttolerance through scheduling of periodic tasks in hard real-time mulfiprocessor systems 显示文摘 | Ghosh Sunondo Melhem Rami Mosse Daniel | 1997 | IEEE Transactions on Parallel and Distributed Systems1997，8，3： | 1 |
| 4 | Scheduling with Dynamic Voltage/Speed Adjustment Using Slack Reclamation in Multi-Processor Real-Time Systems显示文摘 | Dakai Zhu Rami G Melhem Bruce R Childers | 2003 | IEEE Trans on Parallel & Distributed Systems2003，14，7： | 1 |
| 5 | Power anagement points in power-aware real-time systems显示文摘 | Rami Melhem Nevine AbouGhazaleh Hakan Aydin | 2002 | Power aware computing2002，，7： | 1 |
| 6 | Power-aware scheduling for periodic real-time tasks显示文摘 | Aydin Hakan Melhem Rami Mosse Daniel | 2004 | IEEE Transactions on Computers2004，53，5： | 1 |
| 7 | Scheduling with dynamic voltage/speed adjustment using slack reclamation in multiprocessor real-time systems显示文摘 | Zhu Dakai Melhem Rami Childers Bruce R | 2003 | IEEE Transactions on Parallel and Distributed Systems2003，14，7： | 1 |
| 8 | Fault - Tolerance Through Scheduling of Aperiodic Tasks in Hard Real - Time Multiprocessor Systems 显示文摘 | Sunondo Ghosh Rami Melhem Daniel Mosse | 1997 | IEEE Transactions On Parallel And Distributed Systems1997，8，3： | 1 |
| 9 | Tolerancet o multiple faults for aperiodic tasks in hard real time system显示文摘 | Frank Liberato Rami Melhem Daniel Mosse | | 0，，09： | 1 |
| 10 | Scheduling with dynamic voltage/speed adjustment using slack reclamation in multiprocessor real-time systems显示文摘 | Dakai Zhu Rami Melhem Bruce R Childers | 2003 | IEEE Trans on Parallel and Distributed Systems2003，14，7： | 1 |
| 11 | The interplay of power management and fault recovery in real-time systems 显示文摘 | Rami Melhem Daniel Mosse Elmootazbellah Elnozahy | 2004 | IEEE Trans on Computers2004，53，2： | 1 |
| 12 | An optimalboundary fair schudling algorithm for multiprocessor real-time sys-tems 显示文摘 | Dakai Zhu XUAN QI Daniel Mosse Rami Melhem | 2011 | Journal of Parallel and Distributed Computing2011，10，71： | 1 |
| 13 | Scheduling with dynamic voltage/speed adjustment using slack reclamation in multiprocessor real-time systems显示文摘 | Dakai Zhu Rami Melhem Bruce R Childers | 2003 | IEEE Transaction on Parallel and Distributed Systems July2003，14，7： | 1 |
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