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| 1 | Serum and glucocorticoid inducible protein kinases(SGKs):a potential target for cancer intervention显示文摘The serum and glucocorticoid inducible protein kinase(SGK) family members share similar structure, substrate specificity and function with AKT and signal downstream of the phosphatidylinositol 3-kinase(PI3K) signalling pathway. They regulate a range of fundamental cellular processes such as cell proliferation and survival, thereby playing an important role in cancer development. This perspective intends to give an overview on the involvement of SGKs(particularly SGK3) in cancer progression, and compares the actions of SGK3 and AKT in cell cycle regulation, oncogenic signalling, and the potential as a therapeutic target for cancer. | Rajesh Basnet Grace Qun Gong Chenyao Li Ming-Wei Wang | 2018 | Acta Pharmaceutica Sinica B2018，8，5： | 9 |
| 2 | Identification, structure modification, and characterization of potential small-molecule SGK3 inhibitors with novel scaffolds显示文摘The serum and glucocorticoid-regulated kinase (SGK) family has been implicated in the regulation of many cellular processes downstream of the PI3K pathway. It plays a crucial role in PI3K-mediated tumorigenesis, making it a potential therapeutic target for cancer. SGK family consists of three isoforms (SGK1, SGK2, and SGK3), which have high sequence homology in the kinase domain and similar substrate speci?city with the AKT family. In order to identify novel compounds capable of inhibiting SGK3 activity, a high-throughput screening campaign against 50,400 small molecules was conducted using a fuorescence-based kinase assay that has a Z' factor above 0.5. It identiifed 15 hits (including nitrogen-containing aromatic, favone, hydrazone, and naphthalene derivatives) with IC50 values in the low micromolar to sub-micromolar range. Four compounds with a similar scaffold (i.e., a hydrazone core) were selected for structural modi?cation and 18 derivatives were synthesized. Molecular modeling was then used to investigate the structure-activity relationship (SAR) and potential protein–ligand interactions. As a result, a series of SGK inhibitors that are active against both SGK1 and SGK3 were developed and important functional groups that control their inhibitory activity identified. | Grace Qun Gong Ke Wang Xin-Chuan Dai Yan Zhou Rajesh Basnet Yi Chen De-Hua Yang Woo-Jeong Lee Christina Maree Buchanan Jack Urquhart Flanagan Peter Robin Shepherd Ying Chen Ming-Wei Wang | 2018 | Acta Pharmacologica Sinica2018，39，12： | 1 |
| 3 | Effect of plasma treatment on the seed germination and seedling growth of radish(Raphanus sativus)显示文摘The effect on the germination and seedling growth of radish(Raphanus sativus)seeds were examined employing a dielectric barrier discharge(DBD)at atmospheric pressure and room temperature for various treatment time.DBD plasma using argon gas of flow rate 21 m^(-1)was employed in this study.Radish seeds were treated with DBD plasma for 1-5 min,respectively.Germination characteristics,seedling growth parameters,the contact angle of the seed coat,water uptake capacity,mass loss,the temperature of the seeds,chlorophyll,and carotenoid contents of the seedlings were measured before and after the DBD plasma treatments.Plasma treatment of radish seeds significantly increased germination-related characters,including germination percentage,fresh and dry weight,vigor index,and total carotenoids contents.However,the cumulative production rate was found to be decreased.Results from the experiment indicate an acceleration in the water uptake of the radish seeds and make the seed surface hydrophilic by plasma treatment.Scanning electron microscopy analysis showed that etching effects on the seed coat occurred after the argon plasma treatments,which affected the wettability of the radish seed.The experimental findings showed that seeds being treated by DBD plasma for 2 and 3 min had a positive effect on the germination and seedling growth of radish. | Rajesh Prakash GURAGAIN Hom Bahadur BANIYA Santosh DHUNGANA Ganesh Kuwar CHHETRI Binita SEDHAI Niroj BASNET Aavash SHAKYA Bishnu Prasad PANDEY Suman Prakash PRADHAN Ujjwal Man JOSHI Deepak Prasad SUBEDI | 2022 | Plasma Science and Technology2022，24，1： | 0 |
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