|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current and emerging therapies in unresectable and recurrent gastric cancer显示文摘Gastric cancer is one of the most lethal cancers worldwide despite many advances and options in therapy. As it is often diagnosed at an advanced stage, prognosis is poor with a median overall survival of less than twelve months. Chemotherapy remains the mainstay of treatment for these patients but it confersonly a moderate survival advantage. There remains a need for new targeted treatment options and a way to better define patient populations who will benefit from these agents. In the past few years, there has been a better understanding of the biology, molecular profiling, and heterogeneity of gastric cancer. Our increased knowledge has led to the identification of gastric cancer subtypes and to the development of new targeted therapeutic agents. There are now two new targeted agents, trastuzumab and ramucirumab, that have recently been approved for the treatment of advanced and metastatic gastric cancer. There are also many other actively investigated targets, including epidermal growth factor receptor, the phosphatadylinositol 3-kinase/protein kinase B/mammalian target of rapamycin pathway, c-Met, poly ADP-ribose polymerase, and immune checkpoint inhibition. In this review, we discuss the current management of advanced gastric cancer as well as emerging targeted therapies and immunotherapy. | Erin Jou Lakshmi Rajdev | 2016 | World Journal of Gastroenterology2016，22，20： | 20 |
| 2 | Multimodality management of resectable gastric cancer: A review显示文摘Adenocarcinoma of the stomach carries a poor prognosis and is the second most common cause of cancer death worldwide. It is recommended that surgical resection with a D1 or a modified D2 gastrectomy(with at least 15 lymph nodes removed for examination), be performed in the United States, though D2 lymphadenectomies should be performed at experienced centers. A D2 lymphadenectomy is the recommended procedure in Asia. Although surgical resection is considered the definitive treatment, rates of recurrences are high, necessitating the need for neoadjuvant or adjuvant therapy. This review article aims to outline and summarize some of the pivotal trials that have defined optimal treatment options for non-metastatic non-cardia gastric cancer. Some of the most notable trials include the INT-0116 trial, which established a benefit in concurrent chemoradiation and adjuvant chemotherapy. This was again confirmed in the ARTIST trial, especially in patients with nodal involvement. Later, the Medical Research Council Adjuvant Gastric Infusional Chemotherapy trial provided evidence for the use of perioperative chemotherapy. Targeted agents such as ramucirumab and trastuzumab are also being investigated for use in locally advanced gastric cancers after demonstrating a benefit in the metastatic setting. Given the poor response rate of this difficult disease to various treatment modalities, numerous studies are currently ongoing in an attempt to define a more effective therapy, some of which are briefly introduced in this review as well. | Helen Shum Lakshmi Rajdev | 2014 | World Journal of Gastrointestinal Oncology2014，6，10： | 2 |
| 3 | Relation of cardiac troponin I levels with in-hospital mortality in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage 显示文摘 | Sandhu R Aronow WS Rajdev A | 2008 | Am J Cardiol2008，102，5： | 1 |
| 4 | Adenylate cyclase activator forskolin alleviates intracerebroventricular propionic acid-induced mitochondrial dysfunction of autistic rats显示文摘Neuronal mitochondrial dysfunction increases inflammatory mediators and leads to free radical generation and anti-oxidant enzymatic alterations,which are major neuropathological hallmarks responsible for autism.Mitochondrial dysfunction in autism is associated with decreased ATP levels due to reduced levels of cyclic adenosine monophosphate.Rat models of autism were established by intracerebroventricular injection of propionic acid.These rat models had memory dysfunction,decreased muscle coordination and gait imbalance.Biochemical estimation of propionic acid-treated rats showed changes in enzyme activity in neuronal mitochondrial electron transport chain complexes and increases in pro-inflammatory cytokines,oxidative stress and lipid biomarkers.Oral administration of 10,20 and 30 mg/kg adenylate cyclase activator forskolin for 15 days reversed these changes in a dose-dependent manner.These findings suggest that forskolin can alleviate neuronal mitochondrial dysfunction and improve neurological symptoms of rats with autism.This study was approved by the RITS/IAEC,SIRSA,HARYANA on March 3,2014(approval No.RITS/IAEC/2014/03/03). | Sidharth Mehan Saloni Rahi Aarti Tiwari Tarun Kapoor Kajal Rajdev Ramit Sharma Himanshi Khera Sourabh Kosey Umesh Kukkar Rajesh Dudi | 2020 | Neural Regeneration Research2020，15，6： | 1 |
| 5 | Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction 显示文摘 | Rajdev S Hara K Kokubo Y | 2000 | Ann Neurol2000，47，6： | 1 |
| 6 | Mice overexpressing rat heats shock protein 70 are protected against cerebral infarction显示文摘 | RAJDEV S HARA K KOKUBO Y | 2000 | Ann Neurol2000，47，6： | 1 |
| 7 | Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia显示文摘 | Kokubo Y Liu J Rajdev S el al | 2003 | Neurosurgery2003，53，1： | 1 |
| 8 | Phase Ⅱ study of weekly docetaxel alone or in combination with trastuzumab in patients with metastatic breast cancer显示文摘 | Raff JP Rajdev L Malik U | 2004 | Clin Breast Cancer2004，4，： | 1 |
| 9 | Arrhythmias in pulmonary arterial hypertension显示文摘 | Rajdev A Garan H Biviano A | | 0，，02： | 1 |
| 10 | Relation of cardiac troponin I levels with in-hospital mortality in patients with ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage 显示文摘 | Sandhu R Aronow WS Rajdev A | 2008 | Am J Cardiol2008，102，5： | 1 |
| 11 | Differential cerebral protein synthesis and heat shock protein 70 expression in the core and penumbra of rat brain after transient focal ischemia显示文摘 | Kokubo Y Liu J Rajdev S | 2003 | Neurosurgery2003，53，1： | 1 |
| 12 | Temaozolomide(Temadar)显示文摘 | Wesolowski J R Rajdev P Mukheiji S K | 2010 | Am J Neuroradiol2010，31，8： | 1 |
| 13 | Outcome of intracoro- nary stenting after failed maxinalmedical therapy in patients with symptomatic myocardial bridge显示文摘 | Kunamneni PB Rajdev S Krishnan P etal | 2008 | Catheter Cardiovasc Interv2008，71，2： | 1 |
| 14 | Outcome of intracoronary stenting after failed maximal medical therapy in patients with symptomatic myocardial bridge 显示文摘 | Kunamneni P B Rajdev S Krishnan P Moreno P R Kim M C Sharma S K | 2008 | Catheter Cardiovasc Interv2008，71，： | 1 |
| 15 | Pathophysiology of bone metastases显示文摘 | Berenson JR Rajdev I Broder M | 2006 | Cancer Biol Ther2006，5，9： | 1 |
| 16 | Real-time seizure predic- tion from local field potentials using an adaptive Wiener algorithm显示文摘 | RAJDEV P WARD M RICKUS J | 2010 | Computers in Biology and Medicine2010，40，1： | 1 |
| 17 | Clinical application of prophylactic percutaneous left ventricular assist device(Tandem Heart)in high-risk percutaneous coronary intervention using an arterial preclosure technique:single-center experience显示文摘 | Rajdev S Krishnan P Irani A | 2008 | J Invasive Cardiol2008，20，2： | 1 |
| 18 | Mice overexpressing rat heat shock protein 70 are protected against cerebral infarction显示文摘 | Rajdev S Hara K | 2000 | Annals of neurology2000，47，6： | 1 |
| 19 | Pathophysiology of bone metasta-ses显示文摘 | BerensonJ R Rajdev L Broder M | 2006 | Cancer Bioi Ther2006，5，9： | 1 |
| 20 | Managing bone complications of solid tumors显示文摘 | Bcrenson JR Rajdev L Broder M | 2006 | Cancer Biol Ther2006，5，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员